A5087628420- Nerve injury and regeneration
- Autophagy in Disease and Therapy
- Sirtuins and Resveratrol in Medicine
- Endoplasmic Reticulum Stress and Disease
- Neurogenetic and Muscular Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Mitochondrial Function and Pathology
- Amyotrophic Lateral Sclerosis Research
- Spinal Cord Injury Research
- Pain Mechanisms and Treatments
Universitat Autònoma de Barcelona
2016-2021
Biomedical Research Networking Center on Neurodegenerative Diseases
2016-2021
Centro de Investigación Biomédica en Red
2016-2019
Here we used a systems biology approach and artificial intelligence to identify neuroprotective agent for the treatment of peripheral nerve root avulsion. Based on accumulated knowledge neurodegenerative processes that occur in motoneurons after avulsion, built up protein networks converted them into mathematical models. Unbiased proteomic data from our preclinical models were machine learning algorithms restrictions be imposed solutions. Solutions allowed us combinations repurposed drugs as...
Complete restoring of functional connectivity between neurons or target tissue after traumatic lesions is still an unmet medical need. Using models nerve axotomy and compression, we investigated the effect autophagy induction by genetic pharmacological manipulation on motor regeneration. ATG5 NAD+-dependent deacetylase sirtuin-1 (SIRT1) overexpression spinal motoneurons stimulates mTOR-independent facilitates a growth-competent state improving axonal regeneration with better...
Abstract Sirtuin 1 (SIRT1) activity is neuroprotective, and we have recently demonstrated its role in the retrograde degenerative process motoneurons (MNs) spinal cord of rats after peripheral nerve root avulsion (RA) injury. SIRT2 has been suggested to exert effects opposite those SIRT1; however, roles neurodegeneration neuron response injury remain unclear. Here compared neuroprotective potentials SIRT1 activation inhibition a mouse model hypoglossal axotomy. This induced reduction around...
Abstract Injured neurons should engage endogenous mechanisms of self-protection to limit neurodegeneration. Enhancing efficacy these or correcting dysfunctional pathways may be a successful strategy for inducing neuroprotection. Spinal motoneurons retrogradely degenerate after proximal axotomy due mechanical detachment (avulsion) the nerve roots, and this limits recovery nervous system function in patients type trauma. In previously reported proteomic analysis, we demonstrated that autophagy...
An experimental model of spinal root avulsion (RA) is useful to study causal molecular programs that drive retrograde neurodegeneration after neuron-target disconnection. This neurodegenerative process shares common characteristics with neuronal disease-related processes such as the presence endoplasmic reticulum (ER) stress and autophagy flux blockage. We previously found overexpression GRP78 promoted motoneuronal neuroprotection RA. After that, we aimed unravel underlying mechanism by...