A5054979681- Metal complexes synthesis and properties
- DNA and Nucleic Acid Chemistry
- Ferrocene Chemistry and Applications
- Lymphoma Diagnosis and Treatment
- Research on Leishmaniasis Studies
- Protein Structure and Dynamics
- Cell death mechanisms and regulation
- Advanced biosensing and bioanalysis techniques
- Bacteriophages and microbial interactions
- Enzyme Structure and Function
- PARP inhibition in cancer therapy
- Chronic Lymphocytic Leukemia Research
- Cancer therapeutics and mechanisms
- Viral gastroenteritis research and epidemiology
- Trypanosoma species research and implications
- RNA and protein synthesis mechanisms
- DNA Repair Mechanisms
- HIV Research and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Chronic Myeloid Leukemia Treatments
- X-ray Diffraction in Crystallography
- Bioactive Compounds and Antitumor Agents
- Gene expression and cancer classification
Universidad Autónoma de Madrid
2008-2023
Centro de Biología Molecular Severo Ochoa
2006-2023
Consejo Superior de Investigaciones Científicas
2002-2021
Hospital Clínico Universitario Lozano Blesa
1995-2021
National Research Council
2021
Instituto de Ganadería de Montaña
2014
Unidades Centrales Científico-Técnicas
2007
Shaare Zedek Medical Center
2004
Hebrew University of Jerusalem
2004
Hospital de León
2003
Understanding the fundamental principles underlying supramolecular self-assembly may facilitate many developments, from novel antivirals to self-organized nanodevices. Icosahedral virus particles constitute paradigms study using a combination of theory and experiment. Unfortunately, assembly pathways structurally simplest capsids, those more accessible detailed theoretical studies, have been difficult experimentally. We enabled in vitro under close physiological conditions one known, minute...
The antitumor and cellular pharmacological properties of the<i>trans</i>-Pt(IV) complex,<i>trans</i>-[PtCl<sub>2</sub>(OH)<sub>2</sub>(dimethylamine)(isopropylamine)] (compound <b>2</b>) has been evaluated in comparison with its corresponding <i>trans</i>-Pt(II) counterpart,<i>trans</i>-[PtCl<sub>2</sub>(dimethylamine)(isopropylamine)] <b>1</b>). results reported here indicate that compound <b>2</b> markedly circumvents cisplatin resistance 41McisR CH1cisR ovarian tumor cell lines endowed...
Cisplatin is one of the most widely used antitumor drugs. However, as all anticancer drugs currently in clinic, cisplatin shows phenomenon drug resistance (intrinsic or acquired) against a wide variety tumors. Poly (ADP-ribose) polymerase-1 an enzyme involved DNA repair and apoptotic cell death, which may be inhibited to increase chemosensitivity tumor cells so that circumvented. In present study we report PARP-1 inhibitor 3-aminobenzamide (3-AB) increases cytotoxic activity platinum...
Carboplatin is a low-molecular-weight anticancer drug that acts by binding to the nuclear DNA of cells. Thus, efficient delivery platinum drugs nucleus cancer cells may enhance cytotoxicity drug. Efficient requires three levels localization: targeting cancerous tissue, accumulation in cells, and intracellular localization nucleus. Nuclear signals (NLS) are short positively charged basic peptides actively transport large proteins across membrane. We have prepared conjugates which NLS tethered...
Icosahedral viral capsids are made of a large number symmetrically organized protein subunits whose local movements can be essential for infection. In the capsid minute virus mice, events required infection that involve translocation peptides through pores associated with subtle conformational change. vitro, this change reversibly induced by overcoming energy barrier mild heating capsid, but little is known about regions involved in process. Here, we use hydrogen-deuterium exchange coupled...
Abstract The use of non‐pegylated liposomal doxorubicin (Myocet ® ) in diffuse large B‐cell lymphoma (DLBCL) has been investigated retrospective and single‐arm prospective studies. This was a phase 2 trial DLBCL patients ≥60 years old with left ventricular ejection fraction (LVEF) ≥55% randomized to standard R‐CHOP or investigational R‐COMP (with Myocet instead conventional doxorubicin). primary end point evaluate the differences subclinical cardiotoxicity, defined as decrease LVEF <55%...
We have determined the cytotoxic properties of pentamidine isethionate (2) towards promastigotes protozoan parasite Leishmania infantum. The leishmanicidal activity 2 was 60 times higher after 72 h incubation than that cisplatin (4). salt induced a amount programmed cell death (PCD) cisplatin, which is associated with inhibition DNA synthesis and cell-cycle arrest in G2/M phase. Circular dichroism (CD) data indicate binding to calf-thymus (CT-DNA) induces conformational changes double helix,...
We report here the X-ray structure of cytotoxic trans-[PtCl2(dimethylamine)(isopropylamine)]. This trans-platinum compound crystallizes in monoclinic system, with Z = 8, spatial group C2/c unit cell parameters a 19.862(17) Å, b 6.581(3) c 18.563(3) α 90°, β 119.16(3)°, γ V 2119(2) Å3, ρ 2.321 Mg/m3, R 0.0505, and Rw 0.1166 on basis 2339 independent reflections. To our knowledge this is first crystal biologically active containing different aliphatic amines. The DNA binding mode...