A5088505262- Metal complexes synthesis and properties
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Ferrocene Chemistry and Applications
- Inorganic and Organometallic Chemistry
- Click Chemistry and Applications
- Lanthanide and Transition Metal Complexes
- Organometallic Complex Synthesis and Catalysis
- Radiopharmaceutical Chemistry and Applications
- Magnetism in coordination complexes
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Phenothiazines and Benzothiazines Synthesis and Activities
- Metal-Catalyzed Oxygenation Mechanisms
- Computational Drug Discovery Methods
- DNA and Nucleic Acid Chemistry
- Synthesis and Biological Evaluation
- Molecular Sensors and Ion Detection
- Electrochemical Analysis and Applications
- Organometallic Compounds Synthesis and Characterization
- Trace Elements in Health
- Quinazolinone synthesis and applications
- Crystal structures of chemical compounds
- Thermal and Kinetic Analysis
- Cholinesterase and Neurodegenerative Diseases
University of Belgrade
2015-2024
University of Belgrade – Faculty of Chemistry
2018-2024
Institute of General and Physical Chemistry
2016
Ben-Gurion University of the Negev
2008
University of Vienna
2007
Two p-cymenerutheniumchlorido complexes with thiourea derivative of 7-chloroquinoline (C1) and pyridine-3-imidazole (C2) were synthesized starting from [(η6-p-cymene)RuCl2]2 corresponding ligands. The structures determined elemental analysis IR, ESIMS, 1H 13C{1H} NMR, 2D 1H–15N correlation NMR spectroscopy. Cytotoxic activities examined by the MTT assay performed in five human neoplastic cell lines (HeLa, K562, A549, MDA-MB-231, EA.hy926) one nontumor fetal lung fibroblast line (MRC-5)....
The present study describes the synthesis and anticancer activity of novel octahedral Pt(IV) complexes with cyclohexyl functionalized ethylenediamine-N,N'-diacetate-type ligands. Molecular mechanics calculations density functional theory analysis revealed that s-cis is preferred geometry these tetradentate-coordinated (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate. viability cancer cell lines (U251 human glioma, C6 rat L929 mouse fibrosarcoma, B16 melanoma) was assessed by...
Two non-steroidal antiinflammatory drugs indomethacin and mefenamic acid were coordinated to Ru(<sc>ii</sc>)–arenes afford four new complexes.
Abstract Two ruthenium(II) complexes of 2‐acetylpyridine N 4 , ‐dimethylthiosemicarbazone (HL 1 ) and phenanthrenequinone thiosemicarbazone 2 ), namely [Ru II Cl(L )(PPh 3 ] ( have been synthesised characterised by IR, UV/Vis NMR spectroscopy, electrospray mass spectrometry, cyclic voltammetry X‐ray crystallography. In addition, the crystal structure III Cl (L )PPh · dmso 1.25H O 3· O) is reported. The reaction (dmso) with HL 1,3,5‐triaza‐7‐phosphaadamantane (PTA) gives highly water‐soluble...
Despite extensive research on the anticancer properties of Ru complexes with dipyrido[3,2-a:2',3'-c]phenazine (dppz) ligands, their in vivo efficacy is rarely investigated. Aiming to understand whether coordination certain half-sandwich Ru(II)-arene fragments might improve therapeutic potential dppz we prepared a series general formula [(η6-arene)Ru(dppz-R)Cl]PF6, where arene fragment was benzene, toluene, or p-cymene and R -NO2, -Me, -COOMe. All compounds were fully characterized by 1H 13C...
The synthesis and characterization of novel hetrometallic complexes [{ cis ‐PtCl(NH 3 ) 2 ( μ ‐4,4′‐bipyridyl)ZnCl(terpy‐Cl)}](ClO 4 C1a ), trans ‐4,4′‐bipyridyl)ZnCl(terpy)}](ClO C2a ‐pyrazine)ZnCl(terpy‐Cl)}](ClO C3a C4a (where terpy‐Cl = 4′‐chloro‐2,2′:6′,2′′‐terpyridine) was done. Acid–base titrations were performed by UV–Vis spectrophotometric method to evaluate the p K a values corresponding aqua complexes. Interactions between important biomolecules, guanosine‐5′‐monophosphate...
We investigated the cytotoxicity of recently synthesized (S,S)-ethylendiamine-N,N'-di-2-(3-cyclohexyl)propanoic acid esters toward human leukemic cell lines and healthy blood mononuclear cells. Cell viability was assessed by phosphatase assay, apoptosis, differentiation were analyzed flow cytometry electron microscopy, while intracellular localization apoptosis-inducing factor (AIF) determined immunoblotting. It demonstrated that methyl, ethyl, n-propyl toxic to HL-60, REH, MOLT-4, KG-1,...
A ruthenium(II)-arene complex with picolinic acid, [(?6-pcymene) RuCl(pico)]?H2O, was prepared by the reaction of RuCl2]2 acid in a 1:2 molar ratio 2-propanol. The compound characterized elemental analysis, and IR NMR spectroscopy. X-ray diffraction analysis showed that molecule adopts ?three-leg piano-stool? geometry, which is common for this type complexes. cytotoxic activity tested two human cancer cell lines HeLa (cervix) Femx (melanoma) MTT assay. IC50 values were at 82.0 36.2 ?M cells,...
Complexes 1–4, [Ru(L)(bpy)2]PF6, where bpy = 2,2′-bipyridine; HL 3-methylpyridine-2-carboxylic acid (HL1), 6-methylpyridine-2-carboxylic (HL2), 5-bromopyridine-2-carboxylic (HL3) and 6-bromopyridine-2-carboxylic (HL4), were synthesized characterized. The electrochemical character of the complexes was investigated by cyclic voltammetry revealing two reversible reduction waves in negative range potentials, most likely due to a bipyridine moiety. Cytotoxicity studies MTT assay for 72 h drug...
The light-protected reaction of [(eta(6)-p-cymene)Ru(II)Cl(2)](2) with 1-(2-hydroxyethyl)piperazine in dry methanol, followed by addition excess NH(4)PF(6), afforded the complex [(eta(6)-p-cymene)Ru(II)(NH(3))(2)Cl](PF(6)) () 47% yield. Attempts to use same protocol for synthesis [(eta(6)-p-cymene)Os(II)(NH(3))(2)Cl](PF(6)) led isolation binuclear triply methoxido-bridged arene-osmium compound [{(eta(6)-p-cymene)Os}(2)(mu-OCH(3))(3)](PF(6)) (). Both compounds were characterised X-ray...
Abstract Herein we describe the synthesis, characterization, and anticancer activity of novel p ‐cymeneruthenium(II) complexes containing methyl, ethyl, n ‐propyl, ‐butyl esters ( S , )‐ethylenediamine‐ N N′ ‐di‐2‐(3‐cyclohexyl)propanoic acid. The results IR, UV/Vis, ESIMS, 1 H, 13 C NMR characterization reveal that ligand coordination occurs through nitrogen donor atoms ester ligands, with organoruthenium moiety being kept in complex. These ruthenium(II) are cytotoxic toward various cancer...