A5072464359- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Eosinophilic Esophagitis
- Dermatology and Skin Diseases
- Infant Health and Development
- Microscopic Colitis
- Diet and metabolism studies
- Congenital gastrointestinal and neural anomalies
- Barrier Structure and Function Studies
- Stress Responses and Cortisol
- Digestive system and related health
- Child and Adolescent Psychosocial and Emotional Development
- Gastroesophageal reflux and treatments
- Hidradenitis Suppurativa and Treatments
- Inflammatory Bowel Disease
- Child Abuse and Trauma
- COVID-19 Clinical Research Studies
- Dietary Effects on Health
- IL-33, ST2, and ILC Pathways
- Antioxidant Activity and Oxidative Stress
- Celiac Disease Research and Management
- Child Nutrition and Feeding Issues
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
Universitat Autònoma de Barcelona
2012-2025
Vall d'Hebron Institut de Recerca
2014-2025
Vall d'Hebron Hospital Universitari
2012-2025
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2012-2025
Instituto de Salud Carlos III
2021-2025
Ege University
2025
APC Microbiome Institute
2023
University College Cork
2023
University of Minho
2022
Hebron University
2009-2020
<h3>Objective</h3> Recently, the authors demonstrated altered gene expression in jejunal mucosa of diarrhoea-predominant irritable bowel syndrome patients (IBS-D); specifically, showed that genes related to mast cells and intercellular apical junction complex (AJC) were expressed differently than healthy subjects. The aim here was determine whether these alterations are associated with structural abnormalities AJC their relationship cell activation IBS-D clinical manifestations....
Diarrhea-predominant irritable bowel syndrome (IBS-D) patients show altered epithelial permeability and mucosal micro-inflammation in both proximal distal regions of the intestine. The objective this study was to determine molecular events mechanisms clinical role upper small intestinal alterations.Clinical assessment a jejunal biopsy obtained IBS-D healthy subjects. Routine histology immunohistochemistry performed all participants assess number mast cells (MCs) intraepithelial lymphocytes....
The cause of collagenous colitis (CC) and lymphocytic (LC) is unknown epidemiological risk factors for CC LC are not well studied. aim was to evaluate in a case-control study LC.In all, 120 patients with CC, 70 CL, 128 controls were included. For all cases information prospectively recorded. A binary logistic regression analysis performed separately LC.Independent associations observed the diagnosis were: current smoking (odds ratio [OR], 2.4), history polyarthritis (OR, 20.8), consumption...
<h3>Objective</h3> Micro-RNAs (miRNAs) play a crucial role in controlling intestinal epithelial barrier function partly by modulating the expression of tight junction (TJ) proteins. We have previously shown differential messenger RNA (mRNA) correlated with ultrastructural abnormalities patients diarrhoea-predominant IBS (IBS-D). However, participation miRNAs these mRNA-associated findings remains to be established. Our aims were (1) identify differentially expressed small bowel mucosa IBS-D...
<h3>Background and aims</h3> Altered intestinal barrier is associated with immune activation clinical symptoms in diarrhoea-predominant IBS (IBS-D). Increased mucosal antigen load may induce specific responses; however, local antibody production its contribution to aetiopathogenesis remain undefined. This study evaluated the role of humoral activity IBS-D. <h3>Methods</h3> A single jejunal biopsy, luminal content blood were obtained from healthy volunteers (H; n=30) IBS-D (n=49; Rome III...
Summary Background Intestinal immune activation is involved in irritable bowel syndrome ( IBS ) pathophysiology. While most dietary approaches involve food avoidance, there are fewer indications on supplementation. Palmithoylethanolamide, structurally related to the endocannabinoid anandamide, and polydatin compounds which act synergistically reduce mast cell activation. Aim To assess effect count efficacy of palmithoylethanolamide/polydatin patients with . Methods We conducted a pilot,...
The interface between the intestinal lumen and mucosa is location where majority of ingested immunogenic particles face scrutiny vast gastrointestinal immune system. Upon regular physiological conditions, microflora epithelial barrier are well prepared to process daily a huge amount food-derived antigens non-immunogenic particles. Similarly, they ready prevent environmental toxins microbial penetrate further interact with mucosal-associated These functions promote development proper...
Objectives The long-term consequences of COVID-19 infection on the gastrointestinal tract remain unclear. Here, we aimed to evaluate prevalence symptoms and post-COVID-19 disorders gut–brain interaction after hospitalisation for SARS-CoV-2 infection. Design GI-COVID-19 is a prospective, multicentre, controlled study. Patients with without diagnosis were evaluated hospital admission 1, 6 12 months post hospitalisation. Gastrointestinal symptoms, anxiety depression assessed using validated...
INTRODUCTION: Gastrointestinal (GI) symptoms in coronavirus-19 disease (COVID-19) have been reported with great variability and without standardization. In hospitalized patients, we aimed to evaluate the prevalence of GI symptoms, factors associated their occurrence, variation at 1 month. METHODS: The GI-COVID-19 is a prospective, multicenter, controlled study. Patients COVID-19 diagnosis were recruited hospital admission asked for after month, using validated Symptom Rating Scale...
Whether current smoking worsens the clinical course of microscopic colitis (MC) is unknown. The aim was to evaluate impact on MC.One hundred and eighty-four patients (72% women; age, 62.4 ± 1.1 years) with MC (118 collagenous (CC) 66 lymphocytic (LC) were evaluated (39 them smokers). In all patients, habits data at presentation, response therapy, relapses during follow-up prospectively recorded. Risk factors for relapse studied in 160 after a mean 28 1 months. Cox regression analysis used...
Abstract Background Intestinal epithelial dysfunction is a common pathophysiologic feature in irritable bowel syndrome (IBS) patients and might be the link to its clinical manifestations. We previously showed that chronic psychosocial stress induces jejunal barrier dysfunction; however, whether this response gender‐specific thus explain enhanced female susceptibility IBS remains unknown. Methods responses acute were compared age‐matched groups of healthy women men ( n = 10 each) experiencing...
Background and goal Diarrhoea‐predominant irritable bowel syndrome (IBS‐D) exhibits intestinal innate immune mucosal mast cell (MC) activation. MC stabilisers have been shown to improve IBS symptoms but the mechanism is unclear. Our primary aim was investigate effect of oral disodium cromoglycate (DSCG) on jejunal activation specific signalling pathways in IBS‐D, secondarily, its potential clinical benefit. Study Mucosal (by ultrastructural changes, tryptase release gene expression) protein...
Digestive disorders of gut-brain interaction (DGBI) are very common, predominant in females, and usually associated with intestinal barrier dysfunction, dysbiosis, stress. We previously found that females have increased susceptibility to dysfunction response acute However, whether this is changes the small bowel microbiota remains unknown. evaluated stress better understand stress-induced dysfunction. Jejunal biopsies were obtained at baseline 90 min after cold pain or sham Autonomic (blood...
ABSTRACT Background The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic has highlighted the potential exacerbation of gastrointestinal symptoms in patients with disorders gut‐brain interaction (DGBIs). However, distinct symptom trajectories and psychological burden post‐COVID‐19 DGBIs compared pre‐existing irritable bowel (IBS)/functional dyspepsia (FD) non‐DGBI controls remain poorly understood. Objectives To examine long‐term progression comorbidities DGBI, IBS/FD...
Abstract Corticotropin-releasing factor (CRF) has been identified in intestinal mucosal eosinophils and associated with psychological stress gut dysfunction. Irritable bowel syndrome (IBS) is commonly characterized by altered motility, immune activation, increased barrier permeability along heightened susceptibility to psychosocial stress. Despite intensive research, the role of stress-associated dysfunction remains uncertain. In this study, we evaluated eosinophil activation profile CRF...
Chronic psychological stress affects gastrointestinal physiology which may underpin alterations in the immune response and epithelial transport, both functions are partly regulated by enteric nervous system. However, its effects on neuroplasticity still unclear. This study aims to investigate of chronic unpredictable intestinal motility prominent markers function.Adult male C57BL/6J mice were exposed 19 day protocol schedule social defeat overcrowding. We investigated plasma corticosterone,...
There is growing evidence of the significance gastrointestinal complaints in impairment intestinal mucosal barrier function and inflammation fibromyalgia (FM) myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). However, data on permeability gut dysfunction FM ME/CFS are still limited with conflicting results. This study aimed to assess circulating biomarkers potentially related bacterial translocation their association self-reported symptoms these conditions.A pilot multicenter,...
Intestinal manometry is the current gold standard for diagnosing small bowel dysmotility; however, functional significance of abnormal unknown. Our aim was to determine whether, and what extent, intestinal gas propulsion impaired in patients with manometrically proven dysmotility compared healthy controls IBS.Clearance tolerance a jejunal load (12 mL min(-1) 2 h) were measured 15 severe abdominal symptoms evidenced by manometry, IBS subjects. Thereafter, effect neostigmine (0.5 mg i.v....