A5020591397- Genomics, phytochemicals, and oxidative stress
- Chemotherapy-induced organ toxicity mitigation
- Drug-Induced Hepatotoxicity and Protection
- COVID-19 Clinical Research Studies
- Helicobacter pylori-related gastroenterology studies
- Long-Term Effects of COVID-19
- Alcohol Consumption and Health Effects
- COVID-19 and Mental Health
- Gastrointestinal disorders and treatments
- Renal Diseases and Glomerulopathies
- Hepatitis B Virus Studies
- Metabolism and Genetic Disorders
- Abdominal vascular conditions and treatments
- Boron Compounds in Chemistry
- Ginger and Zingiberaceae research
- Microscopic Colitis
- Pharmacological Effects of Natural Compounds
- Plant-derived Lignans Synthesis and Bioactivity
- Arsenic contamination and mitigation
- Carcinogens and Genotoxicity Assessment
- Artificial Intelligence in Healthcare
- Eicosanoids and Hypertension Pharmacology
- Pharmacology and Obesity Treatment
- Diet, Metabolism, and Disease
- Spondyloarthritis Studies and Treatments
Eskişehir City Hospital
2021-2025
Ministry of Health
2021-2025
Türkiye Yüksek İhtisas Hastanesi
2002
Objectives The long-term consequences of COVID-19 infection on the gastrointestinal tract remain unclear. Here, we aimed to evaluate prevalence symptoms and post-COVID-19 disorders gut–brain interaction after hospitalisation for SARS-CoV-2 infection. Design GI-COVID-19 is a prospective, multicentre, controlled study. Patients with without diagnosis were evaluated hospital admission 1, 6 12 months post hospitalisation. Gastrointestinal symptoms, anxiety depression assessed using validated...
INTRODUCTION: Gastrointestinal (GI) symptoms in coronavirus-19 disease (COVID-19) have been reported with great variability and without standardization. In hospitalized patients, we aimed to evaluate the prevalence of GI symptoms, factors associated their occurrence, variation at 1 month. METHODS: The GI-COVID-19 is a prospective, multicenter, controlled study. Patients COVID-19 diagnosis were recruited hospital admission asked for after month, using validated Symptom Rating Scale...
Abstract In the present study, we investigated protective effect of magnolin (MAG) against oxidative stress induced by cyclophosphamide (CP) and its role in Nrf2/HO-1 signaling pathway. Rats were administered MAG (1 mg/kg, i.p.) for 14 days CP (75 on 14th day. administration increased tissue damage, as evidenced elevated levels transaminases (aspartate alanine), alkaline phosphatase, renal parameters (blood urea nitrogen creatinine). Additionally, 8-hydroxy-2′-deoxyguanosine malondialdehyde...
ABSTRACT Cisplatin (CIS) is a chemotherapeutic agent frequently used in cancer treatment. However, depending on the dosage and duration of use, CIS can lead to hepatotoxicity nephrotoxicity. Iristectorin A (IRIS), natural flavonoid, has been found exhibit antioxidant protective effects. In this paper, we scrutinized effects molecular mechanisms IRIS CIS‐induced liver kidney damage mice. administration alleviated elevations AST, ALT, ALP, BUN, creatinine levels by approximately 12%, 15%, 11%,...
ABSTRACT Cyclophosphamide (CYC) is one of the most potent antineoplastic drugs; however, hepatonephrotoxicity, observed following its use, remains severe side effects. Previous studies have reported that syringaldehyde (SYA), a flavonoid compound, exhibits anti‐inflammatory and antioxidant properties. However, it unclear whether SYA has any effects on hepatonephrotoxicity caused by drugs. In present research, we thoroughly evaluated cyclophosphamide‐induced in mouse model, focusing Nrf2/HO‐1...
Abstract Cisplatin (CIS) is a highly effective chemotherapeutic drug, but one of its most serious side effects hepatonephrotoxicity, which varies based on dosage and duration use. Previous studies have reported that obtusifolin (OBS) exhibits several pharmacological effects, including antioxidant antidiabetic activities. In this study, we investigated the protective OBS against CIS-induced hepatonephrotoxicity. (0.5 1 mg/kg, i.p.) was administered to male mice for 10 days, while CIS (20 day...
ABSTRACT Background The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic has highlighted the potential exacerbation of gastrointestinal symptoms in patients with disorders gut‐brain interaction (DGBIs). However, distinct symptom trajectories and psychological burden post‐COVID‐19 DGBIs compared pre‐existing irritable bowel (IBS)/functional dyspepsia (FD) non‐DGBI controls remain poorly understood. Objectives To examine long‐term progression comorbidities DGBI, IBS/FD...
The most prominent adverse effects of nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (DF) are hepato-renal damage. Natural antioxidants can be preferred an alternative and/or combination to improve this This present study was conducted evaluate the protective effect Tubuloside A (TA) against (DF)-induced TA (1 mg/kg, ip) administered male Sprague-Dawley rats for 5 days, and DF (50 on Days 4 5. Plasma aspartate amino transferase, alanine alkaline phosphatase, blood urea...
Abstract 2,4-dichlorophenoxyacetic acid (2,4-D) and arsenic cause severe extensive biological toxicity in organisms. However, their interactions toxic mechanisms co-exposure remain to be fully elucidated. In this study, 28 four-week-old female rats were divided into four groups exposed 100 mg/L or/and 600 2,4-D through drinking water for a period of days. As result, it was revealed that biochemical indicators (ALT, AST, ALP, blood urea nitrogen, creatinine) increased decreased hormonal...
Objective: Ovarian carcinoma is one of the most lethal gynecological cancers, as it responds later to diagnostic methods and therapeutic responses in advanced stages. Many phytochemical compounds have been shown be protective against cancer. Tubuloside A (TbA) main compound extracted from plant Cistanche tubulosa, its pharmacological effects studied broadly. Until now, role TbA human ovarian unknown. The goal this study was evaluate on DNA damage apoptosis A2780 cell lines. Methods:...
Günümüzde alkol alımı sindirim sistemi hastalıkları başta olmak üzere birçok hastalığın önemli bir etkenidir. Dopamin agonistlerinin kaynaklı hasarlar üzerinde iyileşmeye yardımcı olduğunun bilinmesine karşın, bupropionun etanol değişen biyokimyasal parametreler üzerindeki etkileri tam olarak açıklığa kavuşturulmamıştır. Bu çalışma uygulaması ile bazı etkisini değerlendirmek için gerçekleştirildi. Çalışmada ratlara haftada iki kez dört hafta süreyle % 56 yapıldı ve sonrasında bupropion 30 60...