A5101404393- Microscopic Colitis
- Inflammatory Bowel Disease
- Hidradenitis Suppurativa and Treatments
- Autoimmune and Inflammatory Disorders
- Helicobacter pylori-related gastroenterology studies
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal motility and disorders
- Celiac Disease Research and Management
- Gut microbiota and health
- Systemic Lupus Erythematosus Research
- Protease and Inhibitor Mechanisms
- IL-33, ST2, and ILC Pathways
- Gastroesophageal reflux and treatments
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Infectious Aortic and Vascular Conditions
- Renal and related cancers
- Phagocytosis and Immune Regulation
- Nuclear Receptors and Signaling
- Gastric Cancer Management and Outcomes
- Medical Device Sterilization and Disinfection
Universitat de Barcelona
1998-2022
Mútua Terrassa
2006-2022
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2013-2016
University Hospital Mútua de Terrassa
1997-2013
University of Alberta
2000
Duke University
2000
Hebron University
1997
Universitat Autònoma de Barcelona
1997
Vall d'Hebron Hospital Universitari
1994
Microscopic colitis is a rare disease of unknown etiology. It has been described that some drugs could cause or worsen the disease; however, scientific evidence limited.To investigate possible association chronic drug consumption with microscopic colitis.This was case-control study in which groups cases were: Group 1-39 patients collagenous colitis; 2-39 lymphocytic and 3-52 watery diarrhea functional characteristics. 103 subjects formed control group. At diagnosis, history at least 2-wk...
Background: Refractory microscopic colitis is a rare condition with an unknown rate of occurrence. The efficacy anti-tumor necrosis factor (TNF) therapy for has never been reported. Aims: 1) To report the frequency refractory in database participant hospitals. 2) describe therapeutic response to anti-TNF among cases. Methods: Patients histological diagnosis collagenous and lymphocytic were identified through Department Pathology IBD practice database. medical treatment severe symptoms...
The cause of collagenous colitis (CC) and lymphocytic (LC) is unknown epidemiological risk factors for CC LC are not well studied. aim was to evaluate in a case-control study LC.In all, 120 patients with CC, 70 CL, 128 controls were included. For all cases information prospectively recorded. A binary logistic regression analysis performed separately LC.Independent associations observed the diagnosis were: current smoking (odds ratio [OR], 2.4), history polyarthritis (OR, 20.8), consumption...
<h3>Objectives</h3> Nr5a2 participates in biliary acid metabolism and is a major regulator of the pancreatic exocrine programme. Single nucleotide polymorphisms vicinity <i>NR5A2</i> are associated with risk ductal adenocarcinoma (PDAC). <h3>Aims</h3> To determine role homeostasis, damage-induced regeneration mutant <i>KRas</i>-driven tumourigenesis. <h3>Design</h3> <i>Nr5a2</i><sup>+/−</sup> <i>KRas<sup>G12V</sup>;Ptf1a-Cre;Nr5a2</i><sup>+/−</sup> mice were used to investigate whether full...
Abstract Proteolysis and degradation of extracellular matrix by metalloproteinases (MMPs) may contribute to intestinal injury in inflammatory bowel disease. In the present study, we investigated pathogenic role gelatinases (MMP-9 MMP-2) on transmural colonic a rat model chronic colitis, which was induced intracolonic instillation trinitrobenzene sulfonic acid (TNBS). The activity expression MMP-2 MMP-9 were measured tissue peripheral neutrophils fluorescence, zymography, Western blot, or...
There is very limited information regarding region-specific immunological response in human intestine. We aimed to determine differences immune compartmentalisation between ileum and colon healthy inflamed mucosa.T cell profile its apoptosis were measured by flow cytometry, Th1, Th17, Treg [CD4(+)CD25(+)FOXP3(+)], double positive [DP, CD3(+)CD4(+)CD8(+)] negative T cells [DN, CD3(+)CD4(-)CD8(-)], immunohistochemistry [FOXP3, caspase-3], real-time polymerase chain reaction [PCR] [IFN-γ,...
BackgroundApoptosis resistance of T-cells is considered an abnormality immune pathways in Crohn's disease (CD). It has been previously shown that corticosteroids induce apoptosis cells involved inflammation. Thus, our aim was to assess the mononuclear and pro/antiinflammatory cytokines intestinal mucosa patients with active CD, related steroid response, identify cellular molecular factors may predict this response therapy.
Objective: One-week triple therapy has been shown to be effective in Helicobacter pylori eradication and duodenal ulcer healing. However, the optimal therapeutic combination not yet identified. Bismuth-containing regimens have advantage of requiring only one antibiotic. It suggested that high doses omeprazole improve bactericidal efficacy antimicrobial against H. pylori. We evaluated two 1-wk triple-therapy for Methods: On an intention-to-treat basis, 182 patients with pylori-associated were...
The mucosal release of inflammatory mediators is enhanced in active bowel disease. This study examines whether leukotriene C4 production occurs apparently unaffected segments the gut. intraluminal was determined by jejunal perfusion seven healthy controls, nine patients with chronic ulcerative colitis, and 13 Crohn9s disease (six ileal disease, only colonic). All were clinical remission none them had evidence involvement. Mild irritation a 2.5 mmol/l deoxycholic acid solution induced to...
Bacteria and their products stimulate inflammatory responses may play a role in the pathogenesis of bowel diseases. We investigated interactions between fecal flora injured colonic mucosa using trinitrobenzenesulfonic acid model colitis rat. First, we tested effects broad-spectrum antibiotics administered at different times after induction colitis. Second, rats pretreated with antibiotics, studied reintroduction on release mediators morphology lesions. Antibiotics reduced lesion scores when...
Bacteria and their products stimulate inflammatory responses may play a role in the pathogenesis of bowel diseases. We investigated interactions between fecal flora injured colonic mucosa using trinitrobenzenesulfonic acid model colitis rat. First, we tested effects broad-spectrum antibiotics administered at different times after induction colitis. Second, rats pretreated with antibiotics, studied reintroduction on release mediators morphology lesions. Antibiotics reduced lesion scores when...
Previous studies suggested that Interleukin-10 (IL-10) depletion in Crohn's disease (CD) could predict outcome. To determine IL-10 blood and at different intestinal locations patients with active CD to assess its potential prognostic capacity identify aggressive CD. Twenty-three were included. Ulcerative colitis (UC), infectious healthy individuals acted as controls. Serum mucosal samples taken baseline 1 month after steroid initiation patients. Patients classified according response....
Background: The etiology of inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC) is yet unknown.Inflammation in UC limited to the large mucosa, thus resection was expected be curative.Nonetheless, about 50% patients undergoing total proctocolectomy with creation an ileal pouch (pouch surgery) develop small intestinal inflammation (pouchitis).We have previously shown that gene expression profiles are associated behavior IBD.One mechanism regulating protein by...