A5007732990- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Cardiovascular Disease and Adiposity
- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Cancer, Lipids, and Metabolism
- Diet, Metabolism, and Disease
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Bone and Dental Protein Studies
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and disorders
- Body Contouring and Surgery
- IL-33, ST2, and ILC Pathways
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Inflammasome and immune disorders
- Biochemical Analysis and Sensing Techniques
- Ion Transport and Channel Regulation
- Colorectal Cancer Treatments and Studies
- Retinoids in leukemia and cellular processes
- Thermoregulation and physiological responses
- Angiogenesis and VEGF in Cancer
- Caveolin-1 and cellular processes
- Vitamin D Research Studies
Clinica Universidad de Navarra
2016-2025
Instituto de Salud Carlos III
2016-2025
Navarre Institute of Health Research
2016-2025
Centro de Investigación Biomédica en Red
2015-2024
University of Córdoba
2021
Universidad Complutense de Madrid
2021
Instituto Maimónides de Investigación Biomédica de Córdoba
2021
Al-Azhar University – Gaza
2021
Stellenbosch University
2021
Escuela Nacional de Sanidad
2021
BACKGROUND Genomic studies have yielded important insights into the pathogenesis of obesity. Circulating microRNAs (miRNAs) are valuable biomarkers systemic diseases and potential therapeutic targets. We sought to define circulating pattern miRNAs in obesity examine changes after weight loss. METHODS assessed genomewide miRNA profile cross-sectionally 32 men surgery-induced loss 6 morbidly obese patients. The most relevant were validated 80 longitudinally 22 patients (after loss). evaluated...
To assess the predictive capacity of a recently described equation that we have termed CUN-BAE (Clínica Universidad de Navarra-Body Adiposity Estimator) based on BMI, sex, and age for estimating body fat percentage (BF%) to study its clinical usefulness.We conducted comparison developed with many other anthropometric indices regarding correlation actual BF% in large cohort 6,510 white subjects from both sexes (67% female) representing wide range ages (18-80 years) adiposity. Additionally,...
Obesity favors the development of cardiometabolic alterations such as type 2 diabetes (T2D) and metabolic syndrome (MS). MS are distinguished by an increase in circulating leptin concentrations, parallel to a drop levels adiponectin. Consequently, Adpn/Lep ratio has been suggested maker dysfunctional adipose tissue. We aimed investigate humans (n = 292) reliability biomarker tissue dysfunction. considered that ≥1.0 can be normal, ≥0.5 <1.0 suggests moderate-medium increased risk, <0.5...
The aim of the present work was to study whether leptin-adiponectin axis may have a pathophysiological role in increased systemic inflammation and oxidative stress observed patients with metabolic syndrome (MS). Leptin, adiponectin, markers were measured sample 140 Caucasian subjects (74 males/66 females), aged 28-82 years, 60 80 without MS. Total concentrations adiponectin as well its multimeric forms HMW, MMW LMW significantly lower individuals ratio adiponectin/leptin, marker...
Omentin-1 is a novel adipokine expressed in visceral adipose tissue and negatively associated with insulin resistance obesity. We aimed to study the effects of weight loss-induced improved sensitivity on circulating omentin concentrations.Circulating omentin-1 (ELISA) concentration association metabolic variables was measured 35 obese subjects (18 men, 17 women) before after hypocaloric loss.Baseline concentrations correlated BMI (r = -0.58, p < 0.001), body -0.35, 0.045), fat mass -0.67,...
Objective:Glycerol constitutes an important metabolite for the control of lipid accumulation and glucose homeostasis. The impact obesity obesity-associated type 2 diabetes as well potential regulatory role insulin leptin on aquaglyceroporins (AQP) 3, 7, 9 were analyzed.
Abstract Context: Obesity acts as a cardiovascular risk factor by mechanisms that are not fully understood. Osteopontin (OPN) is proinflammatory mediator involved in tissue remodeling plays role atherosclerosis and diabetes. Objective: The aim of the present study was to compare circulating concentrations OPN its mRNA expression omental adipose lean, overweight, obese individuals analyze effect weight loss. Subjects Methods: Plasma were measured 77 volunteers. obtained from 12 women...
Betatrophin is a secreted protein recently involved in β-cell replication with potential role type 2 diabetes mellitus (T2D).The aim of the present study was to compare circulating concentrations betatrophin human obesity and T2D.Serum were measured by ELISA 153 subjects: 75 obese normoglycemic subjects (OB-NG), 30 impaired glucose tolerance (OB-IGT), 15 T2D (OB-T2D) matched sex, age, body adiposity, comparison 33 lean individuals (LN-NG).Circulating levels significantly decreased further...
GPR55 is a putative cannabinoid receptor, and l-α-lysophosphatidylinositol (LPI) its only known endogenous ligand. We investigated 1) whether expressed in fat liver; 2) the correlation of both LPI with several metabolic parameters; 3) actions on human adipocytes. analyzed CB1, CB2, gene expression circulating levels two independent cohorts obese lean subjects, normal or impaired glucose tolerance type 2 diabetes. Ex vivo experiments were used to measure intracellular calcium lipid...
Fibroblast growth factor 15/19 (FGF15/19), an enterokine that regulates synthesis of hepatic bile acids (BA), has been proposed to influence fat metabolism. Without FGF15/19, mouse liver regeneration after partial hepatectomy (PH) is severely impaired. We studied the role FGF15/19 in response a high diet (HFD) and its regulation by saturated fatty acids. developed fusion molecule encompassing FGF19 apolipoprotein A-I, termed Fibapo, evaluated pharmacological properties regeneration.Fgf15-/-...
Aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) encompass a subfamily of aquaporins that allow the movement water other small solutes, especially glycerol, through cell membranes. Adipose tissue constitutes major source glycerol via AQP7. We have recently reported that, in addition to well-known expression AQP7 adipose tissue, AQP3 are also expressed omental subcutaneous fat depots. Moreover, insulin leptin act as regulators aquaglyceroporins PI3K/Akt/mTOR pathway. appear facilitate efflux...
It has been suggested that individuals with the condition known as metabolically healthy obesity (MHO) may not have same increased risk for development of metabolic abnormalities their non-metabolically counterparts. However, validity this concept recently challenged, since it translate into lower morbidity and mortality. The aim current study was to compare cardiometabolic/inflammatory profile prevalence impaired glucose tolerance (IGT) type 2 diabetes (T2D) in patients categorized having...
Calprotectin has been recently described as a novel marker of obesity. The aim this study was to determine the circulating concentrations and expression levels calprotectin subunits (S100A8 S100A9) in visceral adipose tissue (VAT), exploring its impact on insulin resistance inflammation effect weight loss. We included 53 subjects study. Gene S100A8/A9 complex were analyzed VAT well both adipocytes stromovascular fraction cells (SVFCs). In addition, soluble receptor for advanced glycation end...