A5053343667- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- PARP inhibition in cancer therapy
- Regulation of Appetite and Obesity
- Metal complexes synthesis and properties
- Brain Metastases and Treatment
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Genetic and rare skin diseases.
- Cancer and Skin Lesions
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Immunotherapy and Biomarkers
- Protease and Inhibitor Mechanisms
- Colorectal Cancer Treatments and Studies
- Nuclear Receptors and Signaling
- Tissue Engineering and Regenerative Medicine
- Protein Interaction Studies and Fluorescence Analysis
- Melanoma and MAPK Pathways
- Metabolism and Genetic Disorders
- Neurosurgical Procedures and Complications
University of Castilla-La Mancha
2005-2025
Instituto Nacional de Cancerología
2024-2025
University of Wisconsin–Madison
2024
Hospital Universitario de La Princesa
2017-2020
Hospital Universitario Reina Sofía
2016
Hospital General Universitario de Albacete
2010-2014
Serine Proteases and Pathophysiology of the neurovascular Unit
2011
Universidad de Navarra
2009-2011
Inserm
2011
University of Washington
2011
Summary Atherosclerosis is the most common pathophysiologic substrate of coronary artery disease (CAD).Whereas plaque progression and arterial remodeling are critical components in chronic CAD, intracoronary thrombosis over disruption causally related to acute CAD. It was objective this study investigate differences between prior CAD by a simple global coagulation assay measuring thrombin generation. A cross-sectional involving 15 healthy controls, 35 patients with stable 60 after an episode...
The fibrinolytic and matrix metalloproteinase (MMP) systems cooperate in thrombus dissolution extracellular proteolysis. plasminogen/plasmin system activates MMPs, some MMPs have been involved the of fibrin by targeting fibrin(ogen) directly or collaborating with plasmin. MMP-10 has implicated inflammatory/thrombotic processes vascular integrity, but whether could a profibrinolytic effect represent promising thrombolytic agent is unknown.The on fibrinolysis was studied vitro vivo,...
Abstract The hypothalamus integrates peripheral signals and modulates food intake energy expenditure by regulating the metabolic function of tissues, including liver adipose tissue. In a previous study, we demonstrated that s-resistin, an intracellular resistin isoform highly expressed in upregulated during aging, is important central control homeostasis, affecting mainly response to insulin still unknown mechanisms. Herein, using intracerebroventricular injection specific lentiviral RNAi...
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The insulin receptor (IR) occurs as two alternatively spliced isoforms, IR-A (exon 11−) and IR-B 11+), which exhibit functional differences are expressed in a tissue-specific manner. IR substrate (IRS) proteins 1, 2 3 also differ function tissue distribution. Here we show the differential gene expression of IRs IRSs several rat target tissues action. is significantly higher than epididymal white adipose adipogenesis induces shift species from A to B isoform. Moreover, since aging associated...
Neuroblastoma, a tumor of the peripheral sympathetic nervous system, is most common and deadly extracranial childhood. The majority high-risk neuroblastoma exhibit amplification MYCN proto-oncogene increased neoangiogenesis. Both protein stabilization angiogenesis are regulated by signaling through receptor tyrosine kinases (RTKs). Therefore, inhibitors RTKs have potential as treatment option for neuroblastoma. We used kinase antibody arrays to profile activity membrane-bound in found...
Increased levels of plasminogen activator inhibitor-1 (PAI-1) have been associated with obesity, aging, insulin resistance, and type 2 diabetes, conditions that contribute to increased cardiovascular risk. PAI-1 is expressed in a variety tissues, but the cellular origin plasma unknown. To link disease, we examined expression glycosylation pattern liver white adipose tissue (WAT) from adult (3 mo) insulin-resistant old (24 Wistar rats. Glycosylated protein was also purified by affinity...
Abstract Leptin enhances the glucose utilization in most insulin target tissues and paradoxically decreases it white adipose tissue (WAT), but knowledge of mechanisms underlying inhibitory effect central leptin on insulin-dependent uptake WAT is limited. After 7 d intracerebroventricular treatment (0.2 μg/d) rats, overall sensitivity responsiveness after acute vivo administration were analyzed. We also performed unilateral denervation to clarify role autonomic nervous system effects...
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Different studies using Aprepitant, a NK1R antagonist currently used as clinical drug for treating chemotherapy-related nausea and vomiting, have demonstrated that pharmacological inhibition of effectively reduces the growth several tumor types such neuroblastoma (NB). In previous work, we series carbohydrate-based Aprepitant analogs, derived from either d-galactose or l-arabinose, shown high affinity antagonistic activity with broad-spectrum anticancer an important selectivity. this new...
The antitumor activity of Ti(IV)-based compounds put them in the spotlight for cancer treatment past, but their lack stability vivo due to a high rate hydrolysis has hindered development as drugs. As possible solution this problem, we have reported synthesis strategy through which combined titanocene fragment, tridentate ligand, and long aliphatic chain. This allowed us generate titanium compound (Myr-Ti) capable interacting with albumin, highly stable water cytotoxic tumor cells[1]....
Abstract Neuroblastoma is an infrequent tumor of childhood usually located at any site containing sympathetic neural tissue—retroperitoneum and adrenal gland being the most common locations, followed by thoracopulmonary region, mediastinum, head neck, pelvis. Two primary renal neuroblastomas were diagnosed in a 6‐yr‐old boy 7‐mo‐old computed tomography (CT)‐guided fine‐needle aspiration (FNA) cytology. The smears contained numerous individually scattered small round cells, with scanty...
Titanium-based therapies have emerged as a promising alternative for the treatment of cancer patients, particularly those with cisplatin resistant tumors. Unfortunately, some titanium compounds show stability and solubility problems that hindered their use in clinical practice. Here, we designed synthesized new complex containing titanocene fragment, tridentate ligand to improve its water, long aliphatic chain, facilitate non-covalent interaction albumin, most abundant protein human serum....
Adrenocortical carcinoma (AC) is a rare neoplasm, usually considered one of the most morbid and lethal human tumors. It occurs primarily in children young adults often presents with advanced and/or metastatic disease.A 9-year-old boy previous diagnosis adrenocortical underwent computed tomography (CT)-guided fine needle aspiration (FNA) for preoperative investigation hepatic mass. All smears revealed abundant groups cells surrounding an interconnective, thin-walled, central vascular core....
Abstract Williams or Williams‐Beuren syndrome (WBS) is a developmental disorder with multisystemic manifestations characterized by distinctive facial features, mental disability unique cognitive and personality profiles, vascular stenoses, growth retardation, occasional infantile hypercalcemia, caused haploinsufficiency for genes deleted in chromosome band 7q11.23. However, the exception of arterial stenoses elastin gene (ELN), no specific implication any other phenotype has been...
It is known that the increased circulating levels of leptin in obesity stimulate inflammatory response by macrophages. However, whether deficient central signaling can modify visceral adipose tissue (vAT) immunometabolism remains to be elucidated. In this work, we reduced normoleptinemic adult Wistar rats chronically administering superactive receptor antagonist (SLA) (D23L/L39A/D40A/F41A) intracerebroventricularly for 21 days and investigated its impact on vAT immunoregulation. SLA infusion...
We report the case of a hypertensive 54-year-old female who had been under treatment with olmesartan (40 mg daily) for month. She was referred due to hypertransaminasemia and also reported asthenia 7 kg weight loss.