Abstract C cells are primarily known for producing calcitonin, a hypocalcemic and hypophosphatemic hormone. Nevertheless, besides their role in calcium homeostasis, may be involved the intrathyroidal regulation of follicular cells, suggesting possible interrelationship between two endocrine populations. If this premise is true, massive changes induced by different agents activity also affect calcitonin‐producing cells. To investigate behaviour those circumstances, we have experimentally...

Thyroid C cells, or parafollicular are mainly known for producing calcitonin, a hormone involved in calcium homeostasis with hypocalcemic and hypophosphatemic effects. Classically, the main endocrine activity of this cell population has been believed to be restricted its roles serum bone metabolism. Nonetheless, last few years evidence accumulating literature regard local regulatory peptides secreted by such as somatostatin, ghrelin, thyrotropin releasing recently described cocaine-...

Melatonin is an indoleamine with a wide spectrum of biological activities other than transmitting photoperiod information, including antioxidant, oncostatic, anti-aging and immunomodulatory properties. Although melatonin synthesized mainly in the pineal gland, tissues have same capacity. In present study, we examined whether two key enzymes biosynthesis, arylalkylamine Nacetyltransferase (AANAT) hydroxyindole-O-methyltransferase (HIOMT) its receptor MT₁ are expressed endocrine thyroid cells...

c-erbB-2 expression has been found to be a potential marker of aggressive biological behaviour in some tumours, but the role played by this oncoprotein development and maintenance thyroid tumours is still controversial. Therefore our objective was determine whether overexpressed large retrospective series human including both from follicular C-cell differentiation.We have studied 67 (10 adenomas, 11 carcinomas, three anaplastic 25 papillary carcinomas 18 medullary 16 metastases)...

Amplification of c-erbB-2 proto-oncogene has been reported in endocrine tumours, but the results were unclear and no predictive prognostic value established case phaeochromocytoma. We investigated immunohistochemical expression oncogene 34 cases human phaeochromocytoma (27 sporadic, seven familial type MEN (multiple neoplasm)) order to find out if it could be used differentiate sporadic forms whether is related tumour biological behaviour.All showed diffuse, generally heterogeneous,...

Primary cilia (PC) are conserved structures in the adult thyroid gland of different mammals. It was recently described that humans, PC usually present as a single copy per follicular cell emerging from apex into lumen.To understand role developed by hormonogenesis better, their changes human functional diseases (diffuse toxic hyperplasia/Graves' disease [GD] and nodular hyperplasia [NH]/nodular goiter), comparison to normal tissue, were investigated using immunofluorescence, morphometry,...

Abstract Since their discovery in different human tissues by Zimmermann 1898, primary cilia have been found the vast majority of cell types vertebrates. Primary are considered to be cellular antennae that occupy an ideal location for interpretation information both from environment and other cells. To date, mammalian thyroid gland, thyrocytes humans dogs (fetuses adults) rat embryos. The present study investigated whether existence this organelle follicular cells is a general event postnatal...

This paper presents the results of investigations into mitotic rates thyroid endocrine cells in normal postnatal rats, aged 1-120 days. Our study revealed considerable age-dependent shifts mean activity follicular and C-cells. The maximum indices cell renewal were reached during first 10 days life, decreasing gradually significantly until 25 At 1 month, there was a significant recuperation division rate for both types, which declined adult rat. These that proliferation C-cells is inversely...

We report 4 new cases of breast carcinoma in teenage girls diagnosed by use histochemical and immunohistochemical methods. These women under 20 years age were found the files our department last 24 (1976-2000). The patients had operable carcinomas corresponding to various histologic types (1 invasive ductal associated with fibroadenoma, 2 secretory carcinomas, 1 lobular-type carcinoma). Simple mastectomy low axillary lymph node dissection was performed postpubertal patients. Only patient...

Thyrotropin-releasing hormone (TRH) synthesized in the hypothalamus has capability of inducing release thyroid-stimulating (TSH) from anterior pituitary, which turn stimulates production thyroid hormones gland. Immunoreactivity for TRH and TRH-like peptides been found some tissues outside nervous system, including thyroid. It demonstrated that C-cells express authentic TRH, affecting secretion by follicular cells. Therefore, could have a paracrine role homeostasis. If this hypothesis is...

The neu/c-erbB-2 oncogene encodes a 185 kDa protein closely homologous to the epidermal growth factor receptor. product (p185) is glycoprotein with an external domain and internal tyrosine kinase activity. Amplification and/or overexpression of p185 related several human adenocarcinomas. Subsequent studies demonstrated its presence in certain neuroendocrine (NE) neoplasms, including phaeochromocytomas, insulinomas medullary thyroid carcinomas. However, relatively little known about role...

Ultimobranchial (UB) remnants are a constant presence in the thyroid throughout rat postnatal life; however, difficulty identifying most immature forms from surrounding tissue prompted us to search for specific marker. With that objective, we applied panel of antibodies reported be their human counterpart, solid cell nests (SCNs), using double immunohistochemistry and immunofluorescence. Our results demonstrated cytokeratin 34βE12 p63 highly sensitive markers immunohistologic screening...

Thirty patients with aortic arch anomalies resulting in tracheo-oesophageal compression were treated during the period 1966 through 1987. These are important causes of upper respiratory and oesophageal obstruction babies small children. Although symptoms started within first months life most cases, only 15 underwent surgery before six a delay more than one year occurred 5. Diagnosis was established by chest roentgenogram, barium oesophagogram angiography. Thirteen (43%) had double arch, 9...

Abstract The ultimobranchial follicles (UBFs) are considered embryonic remnants from the body (UBB). They follicular structures that vary in size and appearance depending on age of rat. main objective this article was to study progressive changes shape, size, frequency UBFs postnatal rat, birth old‐age. To accomplish objective, a systematic morphometric incidental UBF has been carried out 110 Wistar rats different ages both sexes, divided into three groups: 1) young (5–90‐day‐old); 2) adult...

A study on thyroid glands of Wistar rats ages ranging from 1 to 120 days was carried out. The were serially sectioned and stained for calcitonin using the peroxidase antiperoxidase method. All thyroids contained ultimobranchial follicles (UBF) located partially embedded among usual but in a 5-day-old rat this structure showed an unusual position interstitium connective tissue between cartilage trachea gland. We have observed wall that UBF presence not only resting C cells also mitotic...