A5074489748- Traumatic Brain Injury and Neurovascular Disturbances
- Pediatric Hepatobiliary Diseases and Treatments
- Intestinal Malrotation and Obstruction Disorders
- Intracranial Aneurysms: Treatment and Complications
- Congenital Diaphragmatic Hernia Studies
- Congenital Anomalies and Fetal Surgery
- Urological Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- Urologic and reproductive health conditions
- Pediatric Urology and Nephrology Studies
- Hernia repair and management
- Pancreatitis Pathology and Treatment
- Tracheal and airway disorders
- Tumors and Oncological Cases
- Ureteral procedures and complications
- Adenosine and Purinergic Signaling
- Neuroscience and Neuropharmacology Research
- Neurological Disorders and Treatments
- Eicosanoids and Hypertension Pharmacology
- Testicular diseases and treatments
- Vascular anomalies and interventions
- Histiocytic Disorders and Treatments
- Pleural and Pulmonary Diseases
- Neonatal Respiratory Health Research
- Child and Adolescent Health
Hospital Universitario Severo Ochoa
2025
Hospital Universitario Infanta Leonor
2025
Hospital Universitario Ramón y Cajal
2014-2022
Instituto Cajal
2017-2018
Hospital Clínico San Carlos
1994-2016
Universidad Complutense de Madrid
2011
Hospital Universitario La Paz
1989-1991
Universidad Autónoma de Madrid
1982-1990
The endothelium plays a fundamental role in maintaining vascular homeostasis by releasing factors that regulate local blood flow, systemic pressure, and the reactivity of leukocytes platelets. Accordingly, endothelial dysfunction underpins many cardiovascular diseases, including hypertension, myocardial infarction, stroke. Herein, we evaluated mice with endothelial-specific deletion Nppc, which encodes C-type natriuretic peptide (CNP), determined this mediator is essential for multiple...
This study analyzes the time course of changes induced by subarachnoid hemorrhage (SAH) in sensitivity cat cerebral arteries to noradrenaline and serotonin. Cerebral displayed a supersensitivity these amines, which was most marked 3 days after experiment then gradually disappeared. The serotonin greater longer than response noradrenaline. increase vascular contractile SAH similar that seen superior cervical ganglionectomy or intracisternal injections 6-hydroxydopamine. It is suggested may be...
The clinical relevance of IL-1β in chronic inflammation underlying atherosclerosis has been reinforced by recent evidence associating pharmacological inhibition the cytokine with lower cardiovascular risk. Previously, we have demonstrated a direct involvement endothelial senescence. Therefore, this can be key mechanism contributing to sterile inflammatory milieu associated aging, termed inflammaging. In present study, evaluated whether positive feedback NLRP3 inflammasome via NF-κB could...
The effect of subarachnoid hemorrhage (SAH) on the adrenergic innervation cat cerebral arteries was analyzed. Intracisternal injections autologous blood reduced noradrenaline content from perivascular nerves. Dopamine beta-hydroxylase and uptake 3H-noradrenaline were also decreased. These changes returned to normal in a period 2 3 weeks after SAH. Superior cervical ganglionectomy intracisternal 6-hydroxydopamine these three parameters. It is suggested that SAH induces transient denervation...
✓ The effect of removal the left superior cervical ganglion on contractile response to norepinephrine (NE) and 5-hydroxytryptamine (5-HT, serotonin) was studied in isolated segments middle cerebral artery (MCA) posterior communicating (PCoA) cat. Fifteen days after excision, each dose NE elicited a potentiated both MCA PCoA, whichever side they originated. By contrast, 5-HT induced enhanced vasoconstriction at only PCoA from side. When right were challenged against 5-HT, significantly...
IntroductionLipomatosis involvement of the gastrointestinal tract is arare disorder, for which few cases have been reported inmedical literature [1, 2]. Benign tumors small bowelare relatively rare; lipomas are among most commonones, with an incidence in autopsy ranging from 0.04% to4.5% [4]. We report a 10-year-old girl lipomatosisinvolving and large bowel.Case reportA was referred history recurrentabdominal pain last 12 months. Pain severe andgradually increasing right upper abdominal...
BACKGROUND: Vesicoureteral reflux (VUR) is a major urological problem in children. Its incidence ranges from 1 to 3% healthy MATERIALS AND METHODS: We treated 38 children and analysed their data on age, sex, grade, laterality, results of endoscopic treatment (ET), at the different grades reflux. All were operated an Ambulatory Surgery basis, studying complications post-operative course. RESULTS: Thirty-eight patients during period six years, age between one twelve years. VUR was bilateral 24...
Thirty patients with aortic arch anomalies resulting in tracheo-oesophageal compression were treated during the period 1966 through 1987. These are important causes of upper respiratory and oesophageal obstruction babies small children. Although symptoms started within first months life most cases, only 15 underwent surgery before six a delay more than one year occurred 5. Diagnosis was established by chest roentgenogram, barium oesophagogram angiography. Thirteen (43%) had double arch, 9...
Optimal management of varicocele testis in children and adolescents is controversial, but testicular hypotrophy has been suggested as an indication for treatment adolescents. This report concerns the diagnosis left 30 patients aged 6-15 years influence on size. The testicle was significantly smaller than right 14 at enrollment study. All were treated local anaesthesia with percutaneous transfemoral spermatic venography embolization that vein spring coil, followed by 24-hour observation....
Field electrical stimulation (ES), K+ (50 mM) or ionophore X-537A (0.01 induced tritium release from cat cerebral arteries preincubated with [3H]noradrenaline (NA). Adenosine and AMP (0.5 did not modify caused by X-537A, but these agents ATP significantly reduced that elicited ES K+; this reduction was antagonized 1-methyl-3-isobutylxanthine (MIX; 0.05 mM). Inosine the agonist of purinergic A2-receptors, 5'N-ethyl-carboxamide adenosine (NECA; 0.5 had no effect, A2-receptors...