A5072764259- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Protease and Inhibitor Mechanisms
- Inflammasome and immune disorders
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer, Hypoxia, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Histone Deacetylase Inhibitors Research
- Genetics, Aging, and Longevity in Model Organisms
- Angiogenesis and VEGF in Cancer
- Garlic and Onion Studies
- Pulmonary Hypertension Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Diabetes Treatment and Management
- Peptidase Inhibition and Analysis
- Retinal Diseases and Treatments
- Phytochemicals and Antioxidant Activities
- Cancer, Lipids, and Metabolism
- FOXO transcription factor regulation
Universidad Autónoma de Madrid
2022
Hospital Universitario La Paz
2022
Hospital La Paz Institute for Health Research
2022
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2018-2021
Universidad Complutense de Madrid
2018-2021
Hospital Clínico San Carlos
2018-2021
The clinical relevance of IL-1β in chronic inflammation underlying atherosclerosis has been reinforced by recent evidence associating pharmacological inhibition the cytokine with lower cardiovascular risk. Previously, we have demonstrated a direct involvement endothelial senescence. Therefore, this can be key mechanism contributing to sterile inflammatory milieu associated aging, termed inflammaging. In present study, evaluated whether positive feedback NLRP3 inflammasome via NF-κB could...
Abnormal accumulation of senescent cells in the vessel wall leads to a compromised vascular function contributing aging. Soluble DPP4 (dipeptidyl peptidase 4; sDPP4) secretion from visceral adipose tissue is enhanced obesity, now considered progeric condition. sDPP4 triggers deleterious effects, albeit its contribution aging unknown. We aimed explore involvement aging, unraveling molecular pathway by which acts on endothelium.Human endothelial cell senescence was assessed...
Abstract The liver controls metabolic homeostasis in response to fasting and refeeding periods. Glucokinase (GCK) adjusts hepatic glucose phosphorylation blood levels, acting as a sensor. Our objective was determine whether PAS kinase (PASK), nutrient sensor, could be affecting the expression or activity of GCK states key pathways. PASK-deficient mice have impaired insulin signaling (AKT overactivation). Furthermore, PASK deficiency modified several transcription factors involved adjustment...
Metabolic dysfunction in the liver is cause of numerous pathologies, which are associated with an altered redox state. PASK (PAS Domain Kinase) a nutrient and bioenergetic sensor. We contend that could act as oxidative stress sensor and/or control metabolic balance, playing role mitochondrial homeostasis. Using PASK-deficient mice, we observed deficiency promotes antioxidant response mechanisms: lower production ROS/RNS under non-fasting conditions, overexpression genes coding to...
Glucagon-like peptide 1 (GLP-1) and PAS kinase (PASK) control glucose energy homeostasis according to nutritional status. Thus, both availability GLP-1 lead hepatic glycogen synthesis or degradation. We used a murine model discover whether PASK mediates the effect of exendin-4 (GLP-1 analogue) in adaptation metabolism The results indicate that fasting block Pask expression, deficiency disrupts physiological levels blood GLP1 expression receptors after fasting. Under non-fasted state,...
The objective of this study was to investigate the effects onion and apple functional ingredients in homozygous (fa/fa) obese Zucker rats. Rodents were fed three diets: standard diet [obese control (OC) group], containing 10% (OO) group] (OA) for 8 weeks. Food intake body weight gain higher than lean efficiency lower OO AO groups compared with OC group. Within groups, total cholesterol, LDL-cholesterol, triacylglycerols, glucose, insulin triglyceride-glucose index group group,...
Several signaling pathways may be affected during aging. All are regulated by nutrient levels leading to a decline in mitochondrial function and autophagy an increase oxidative stress. PAS Domain Kinase (PASK) is bioenergetic sensor. We have previously found that PASK plays role the control of hepatic metabolic balance homeostasis. To investigate PASK's stress aging, we analyzed function, glucose tolerance, insulin resistance, lipid-related parameters aged PASK-deficient mice. Hepatic Pask...
Introduction: Vascular aging is associated with endothelial cell senescence, favoring low-grade inflammation, dysfunction, and cardiovascular diseases. Cell senescence arises from a wide variety of endogenous exogenous stressors including some anticancer agents such as doxorubicin. Recently, doxorubicin was linked to the innate immunity component NLRP3 inflammasome which implicated in many vascular inflammatory disorders. There need for therapeutic tools help cancer patients who have been...