A5047876972- Estrogen and related hormone effects
- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Hormonal Regulation and Hypertension
- Gynecological conditions and treatments
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Cancer Risks and Factors
- Bladder and Urothelial Cancer Treatments
- Sexual function and dysfunction studies
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Genital Health and Disease
- biodegradable polymer synthesis and properties
- Thyroid Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Plant tissue culture and regeneration
- BRCA gene mutations in cancer
- Genetic factors in colorectal cancer
Maastricht University Medical Centre
2015-2024
Maastricht University
2009-2024
University of Trieste
2009-2024
Health Research Institute of the Balearic Islands
2021-2024
Hospital Son Llatzer
2024
University of Florence
2020-2024
Azienda Ospedaliera Sant'Andrea
2023
Azienda Sanitaria Universitaria Integrata di Trieste
2019-2022
Azienda Ospedaliero Universitaria Ospedali Riuniti
2015-2021
European Society of Gynaecological Oncology
2019
Macrophages play a crucial role in all stages of cutaneous wound healing responses and dysregulation macrophage function can result derailed repair. The phenotype macrophages is influenced by the microenvironment evolves during from more pro-inflammatory (M1) profile early stages, to less inflammatory pro-healing (M2) later aim current study was investigate potential exogenous administration M2 promote an experimental mouse model injury. Bone marrow derived were stimulated in-vitro with IL-4...
About 20% of patients diagnosed with endometrial cancer (EC) are considered high-risk unfavorable prognosis. In the framework European Network for Individualized Treatment in EC (ENITEC), we investigated presence and phenotypic features Circulating Tumor Cells (CTC) patients. CTC isolation was carried out peripheral blood samples from 34 patients, ranging Grade 3 Stage IB to IV carcinomas recurrences, 27 healthy controls using two methodologies. Samples were subjected EpCAM-based...
This group was formed out of the conviction that endometriosis research has not progressed at a pace in proportion to disease severity and negative impact on women's quality life. Furthermore, advancement our understanding this condition requires quantum shift based new theories pathogenesis. With conviction, international calls for may improve condition, leading optimized management or even prevention. To facilitate this, dedicated website serving as repository where all proposed can be...
Context: substantial evidence suggests that the expression of steroid metabolizing enzymes in endometriosis is altered, turning ectopic endometrium into a source 17β-estradiol. However, whether these differences result net increase local 17β-estradiol production/activity has not been shown. Subjects and Methods: The activities most important steroidogenic synthesizing inactivating were determined by HPLC matched eutopic tissue from patients with (n = 14) controls 20). Results: Aromatase...
The human progesterone receptor (PR) is a ligand-dependent transcription factor and two isoforms, (PRA PRB), can be distinguished. PROGINS, PR polymorphic variant, affects PRA PRB acts as risk-modulating in several gynaecological disorders. Little known about the functional consequences of this variant. Here, we characterise properties PROGINS with respect to transcription, mRNA maturation, protein activity proliferation. characterised by 320 bp PV/HS-1 Alu insertion intron G point...
The local interconversions between estrone (low activity) and 17β-estradiol (potent compound) by 17β-hydroxysteroid dehydrogenases (17β-HSDs) can lead to high generation in endometrial cancer (EC). Examine the balance 17β-HSDs reducing (types 1, 5, 12, 7) those oxidizing (2, 4, 8), EC. Reducing 17β-HSD activities (HPLC) mRNA level (RT-PCR) were assessed normal post-menopausal (n = 16), peritumoral endometrium (normal tissue beside cancer, n 13), 58 EC (29 grade 18 2, 11 3). Grade 1 displayed...
Endometriosis affects 10% of the women before menopause and has important personal, professional, societal economic burdens. Because current medical treatments are aimed at reducing symptoms only, novel therapeutic targets should be identified. is estrogen dependent in some patients endometriosis tissue able to produce estrogens an autocrine/paracrine manner. In a number patients, this consequence high local activity 17β-hydroxysteroid-dehydrogenases (17β-HSDs), enzymes generate active from...
Marco Parillo, Carlo Augusto Mallio, Matteo Pileri, Diab Dirawe, Andrea Romano, Alessandro Bozzao, Brent Weinberg, Cosimo Quattrocchi
Abstract Introduction Implantation failure after transferring morphologically “good‐quality” embryos in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) may be explained by impaired endometrial receptivity. Analyzing the transcriptome analysis reveal underlying processes and could help guiding prognosis using targeted interventions for infertility. This exploratory study investigated whether profile was associated with short‐term or long‐term implantation outcomes (ie success...
Therapeutic efficacy of cisplatin-based treatment late stage urothelial carcinoma (UC) is limited by chemoresistance. To elucidate underlying mechanisms and to develop new approaches for overcoming resistance, we generated long-term cisplatin treated (LTT) UC cell lines, characterised their response, determined the expression molecules involved in transport detoxification, DNA repair, apoptosis. Inhibitors metallothioneins Survivin were applied investigate ability sensitise towards...
Circulating leukocytes are an important part of the immune system. The aim this work is to explore role preoperative circulating in serous ovarian carcinoma and investigate whether they can be used predict survival prognosis. Routine blood test results clinical information patients with were retrospectively collected. And according routine result decision tree method was applied build a machine learning model.The showed that number white cells (p = 0.022), monocytes < 0.001), lymphocytes...