A5031366327- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Reproductive Health and Contraception
- Ovarian function and disorders
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
- Anorectal Disease Treatments and Outcomes
- Estrogen and related hormone effects
- Reproductive Health and Technologies
- Pelvic floor disorders treatments
- Reproductive Biology and Fertility
- Reproductive tract infections research
- Urticaria and Related Conditions
- Cardiovascular Issues in Pregnancy
- Pelvic and Acetabular Injuries
- Ectopic Pregnancy Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Renal and related cancers
- Thyroid Cancer Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Hernia repair and management
Heidelberg University
2024
University Hospital Heidelberg
2024
University Medical Center Utrecht
2018-2024
KU Leuven
2019
Máxima Medisch Centrum
2017-2018
Maastricht University
2018
Amsterdam UMC Location University of Amsterdam
2018
Radboud University Nijmegen
2017-2018
Catharina Ziekenhuis
2018
The University of Adelaide
2018
Abstract The endometrial microbiota composition may be associated with implantation success. However, a ‘core’ has not yet been defined. This exploratory study analysed the by 16S rRNA sequencing (V1–V2 region) of 141 infertile women whose first IVF/ICSI cycle failed and compared profiles without live birth within 12 months follow-up, infertility cause type. Lactobacillus was most abundant genus in majority samples. Women to those had significantly higher crispatus relative abundance (RA) (p...
Abstract Introduction Implantation failure after transferring morphologically “good‐quality” embryos in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) may be explained by impaired endometrial receptivity. Analyzing the transcriptome analysis reveal underlying processes and could help guiding prognosis using targeted interventions for infertility. This exploratory study investigated whether profile was associated with short‐term or long‐term implantation outcomes (ie success...
Research questionCan organoids be established from endometrial tissue of infertile women and does cryopreservation allow for establishment comparable to derived freshly biopsied tissue?DesignEndometrial was obtained six through minimally invasive biopsy using a Pipelle catheter subjected organoid development, immediately after as well cryopreservation. Organoid formation efficiency, morphology, expandability potential, marker expression (immunostaining reverse transcription quantitative...
In the Netherlands, couples with unexplained infertility and a good prognosis to conceive spontaneously (i.e. Hunault > 30%) are advised perform timed intercourse for at least another 6 months. If fail within this period, they will usually start assisted reproductive technology (ART). However, treatment of by ART is empirical can involve significant burdens. Intentional endometrial injury, also called 'endometrial scratching', has been proposed positively affect chance embryo implantation in...
To investigate whether the transcriptome profile differs between progesterone-treated infertile and fertile endometrial organoids.
Abstract Infertility is a complex condition affecting millions of couples worldwide. The current definition infertility, based on clinical criteria, fails to account for the molecular and cellular changes that may occur during development infertility. Recent advancements in sequencing technology single-cell analysis offer new opportunities gain deeper understanding these changes. endometrium has potential role infertility been extensively studied identify gene expression profiles associated...
Graphical abstract Abstract Sex steroids are converted to bioactive metabolites and vice versa by endometrial steroid-metabolising enzymes. Studies indicate that alterations in this metabolism might affect receptivity. This pilot study determined whether the formation inactivation of 17β-oestradiol differed between supposedly embryo-receptive endometrium non-receptive women undergoing IVF/intracytoplasmic sperm injection (ICSI). Endometrial biopsies were obtained from IVF/ICSI patients 5–8...
Polycystic ovary syndrome (PCOS) is the most common reproductive disorder in premenopausal women. PCOS characterized by hyperandrogenemia that does not abate after menopause. Hyperandrogenemic postmenopausal women (HA-PMW) are hypertensive, but mechanisms responsible have been elucidated. Hypertension PMW less well controlled than age-matched men. We developed a model, hyperandrogenemic postcycling female (PMHAF) rat, aged 13-14 mos, exhibits many of characteristics found HA-PMW. In present...
Abstract Study question Does the endometrial transcriptome profile differ between infertile women with or without a recurrent implantation failure (RIF)? Summary answer Although two different clusters emerged from data, these were not associated clinical phenotype (RIF vs non-RIF). What is known already Despite transfer of morphologically ‘good-quality’ embryos in IVF/ICSI, often occurs, which may be explained by impaired receptivity. In order to guide prognosis and use effective therapeutic...
Abstract Study question After one failed IVF/ICSI cycle, does the endometrial microbiota composition differ between women who will or not reach a live birth within 12 months? Summary answer The did significantly in with cycle without birth, but statistical power was low. What is known already Evidence for presence of an indigenous microbiome mounting, and its may be associated implantation success. However, ‘core’ has yet been defined, role embryo still poorly understood. Further...