A5038790943- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Gynecological conditions and treatments
- Pregnancy-related medical research
- Ovarian cancer diagnosis and treatment
- Estrogen and related hormone effects
- Ectopic Pregnancy Diagnosis and Management
- Intestinal and Peritoneal Adhesions
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Reproductive Biology and Fertility
- Biochemical and Molecular Research
- Apelin-related biomedical research
- Menstrual Health and Disorders
- Ovarian function and disorders
- Cancer, Hypoxia, and Metabolism
- Alkaline Phosphatase Research Studies
- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Actinomycetales infections and treatment
- Bone and Joint Diseases
- COVID-19 and healthcare impacts
- Biochemical Analysis and Sensing Techniques
Kyoto Prefectural University of Medicine
2015-2024
Kazakh National Medical University
2024
Kochi Medical School Hospital
2024
Kōchi University
2024
Nagasaki University
2009-2021
Nagasaki University Hospital
2015
Nagasaki Municipal Hospital
2006
Oita Prefectural Hospital
1998
Information is limited regarding the multifunctional role of GnRH agonist (GnRHa) therapy in reproductive diseases. We investigated pattern changes inflammatory reaction, micro-vessel density and apoptosis tissues collected from women with endometriosis, adenomyosis uterine myoma who were treated or without GnRHa therapy.Biopsy specimens lesions, myometria corresponding endometria 45 ovarian endometrioma, 35 56 myoma. A fraction these for a variable period 3-6 months before surgery....
Is there any risk of intra-uterine bacterial colonization and concurrent occurrence endometritis in women with endometriosis? An increase microbial occurred endometriosis that was further increased after GnRH agonist (GnRHa) treatment. Higher contamination menstrual blood endotoxin level peritoneal fluids have been found than control women. However, information on across the phases cycle possible is still lacking. This a case-controlled study prospective collection vaginal smears/endometrial...
This group was formed out of the conviction that endometriosis research has not progressed at a pace in proportion to disease severity and negative impact on women's quality life. Furthermore, advancement our understanding this condition requires quantum shift based new theories pathogenesis. With conviction, international calls for may improve condition, leading optimized management or even prevention. To facilitate this, dedicated website serving as repository where all proposed can be...
We recently demonstrated the effect of gonadotrophin-releasing hormone agonist (GnRHa) on tissue inflammation, angiogenesis and apoptosis in endometriosis, adenomyosis uterine myoma. Here, we investigated expression GnRH receptors (GnRHRs) GnRHa proliferation cells derived from endometria pathological lesions women with these reproductive diseases. Biopsy specimens were collected corresponding 35 pelvic 45 ovarian endometrioma, 56 myoma during laparoscopy or laparotomy. The gene protein...
Abstract Context Regulatory T (Treg) cells and T-helper-17 (Th17) may be involved in endometriosis. Information on the pattern of change percentages Treg Th17 peripheral blood (PB) peritoneal fluid (PF) women with early advanced endometriosis is unclear. Objective To investigate PB PF Methods We recruited 31 laparoscopically histologically confirmed, revised American Society Reproductive Medicine stage I-II endometriosis, 39 III-IV 36 control subjects without visible samples were collected...
Abstract Problem Intrauterine microbial colonization and its association with the pathogenesis of endometriosis via an innate immune cascade have been reported. As a potential source transmission, information on in cervical mucus is unknown. We investigated pattern microbiota collected from women without using next‐generation sequencing (NGS) technology. Method study Cervical samples were (n = 30) 39) endometriosis. The communities group control examined by Gram staining NGS targeting V5‐V6...
BACKGROUND: Information regarding macrophage-mediated regulation of hepatocyte growth factor (HGF) by ovarian steroid hormones in women with endometriosis is limited. Therefore, we investigated the HGF isolated macrophages and stromal cells derived from or without endometriosis. METHODS: We CD68 immunoreactive adherent vitro 46 30 Estrogen receptor (ER) progesterone (PR) expression was demonstrated immunohistochemistry RT–PCR. Production culture media basal steroid-stimulated examined...
BACKGROUND: The association between uterine myoma and infertility is still controversial. anatomical defect of endometrium by fibroids could be a factor for reducing pregnancy rates increasing miscarriage rates. However, implantation were found to significantly lower in women with intramural myomas (IMMs), when there was no deformity cavity. This due other biological factors such as increased accumulation inflammatory cells within fibroid tissue corresponding that might impair fertility....
Is there any occurrence of hidden (occult) endometriotic lesions in normal peritoneum women with and without visible endometriosis? We detected a slightly higher occult microscopic endometriosis (OME) than control women. Based on small number cases, the concept invisible visually has been reported for more decade but is controversy regarding their tissue activity clinical significance. This case-controlled research study was conducted prospectively collected peritoneal samples from 151 62...
Is the occurrence of pelvic pain in women with ovarian endometrioma associated coexisting peritoneal lesions (PLs)? Pelvic is usually PLs. An increased tissue inflammatory reaction elevated prostaglandin (PG) production may be responsible for generation pain. Severe reported to deeply infiltrating endometriosis. However, information on endometriosis and without coexistent superficial limited. Retrospective clinical study case-controlled biological research using prospectively collected...
Adenomyosis is commonly believed to arise from the basalis endometrium. As an estromedin growth factor, hepatocyte factor (HGF) exhibits multiple functions in endometriosis, a disease functionalis Here, we investigated role of HGF occurrence epithelial-mesenchymal transition (EMT) adenomyosis. Full-thickness-biopsy specimens endometrium myometrium were collected after hysterectomy women with and without The relationship between E-cadherin (epithelial cell marker) N-cadherin (mesenchymal...
We investigated the expression of hepatocyte growth factor (HGF) gene and protein by stromal cells derived from women with or without endometriosis its regulation interleukin-6 (IL-6) tumour necrosis alpha (TNFalpha).Stromal immunoreactive to vimentin were isolated eutopic ectopic endometrium 18 infertile 12 endometriosis. The production HGF in culture media basal IL-6- TNFalpha-stimulated was examined an enzyme-linked immunosorbent assay. mRNA receptor c-Met stroma RT-PCR. localization...
We investigated the role of human heat-shock protein 70 (Hsp70) in Toll-like receptor 4 (TLR4)-mediated growth endometriosis.TLR4 expression was examined macrophages (M) isolated primary culture from peritoneal fluid women with and without endometriosis. The production a number macromolecules by non-treated M, Hsp70-treated M after treatment anti-TLR4 antibody enzyme linked immunosorbent assay (ELISA). single combined effects Hsp70 lipopolysaccharide (LPS) on endometrial stromal cells were...