A5011449174- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Cancer Cells and Metastasis
- Viral-associated cancers and disorders
- Protease and Inhibitor Mechanisms
- TGF-β signaling in diseases
- Peptidase Inhibition and Analysis
- CNS Lymphoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Blood disorders and treatments
- Genetic factors in colorectal cancer
- Glycosylation and Glycoproteins Research
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Inflammatory Biomarkers in Disease Prognosis
- Ubiquitin and proteasome pathways
- Radiomics and Machine Learning in Medical Imaging
- Protein Degradation and Inhibitors
- Neutropenia and Cancer Infections
- Cancer-related molecular mechanisms research
- Metastasis and carcinoma case studies
- Acute Lymphoblastic Leukemia research
- Circular RNAs in diseases
MD Anderson Cancer Center Madrid
2015-2023
Instituto de Investigaciones Biomédicas Sols-Morreale
2013-2014
Universidad Autónoma de Madrid
2013-2014
Consejo Superior de Investigaciones Científicas
2013
Albert Einstein College of Medicine
2011
Universidad Complutense de Madrid
2005-2010
About 20% of patients diagnosed with endometrial cancer (EC) are considered high-risk unfavorable prognosis. In the framework European Network for Individualized Treatment in EC (ENITEC), we investigated presence and phenotypic features Circulating Tumor Cells (CTC) patients. CTC isolation was carried out peripheral blood samples from 34 patients, ranging Grade 3 Stage IB to IV carcinomas recurrences, 27 healthy controls using two methodologies. Samples were subjected EpCAM-based...
Summary The study included 1848 diffuse large B‐cell lymphoma ( DLBCL )patients treated with chemotherapy/rituximab. aims were to validate the National Comprehensive Cancer Network International Prognostic Index NCCN ‐ IPI ) and explore effect of adding high Beta‐2 microglobulin (β2M), primary extranodal presentation intense treatment variables in order develop an improved index. Comparing survival curves, discriminated better than , separating four risk groups 5‐year overall rates 93%, 83%,...
Abstract BACKGROUND Telomere maintenance has been proposed as an essential step for tumor cell immortalization. The objectives of the current study were to investigate mechanisms implicated in telomere length colorectal carcinoma (CRC) and evaluate prognostic impact status. METHODS Ninety‐one samples that obtained from patients who underwent surgery analyzed factors related function. authors studied telomerase activity, terminal restriction fragment (TRF) length, telomeric‐repeat binding...
Although it is becoming clear that certain miRNAs fulfil a fundamental role in the regulation of epithelial-to-mesenchymal transition (EMT), comprehensive study associated with this process has yet to be performed. Here, we profiled signature miRNA expression an vitro model EMT, ectopically expressing MDCK cells one seven EMT transcription factors (SNAI1, SNAI2, ZEB1, ZEB2, TWIST1, TWIST2 or E47) inducer LOXL2. In way, identified core subset deregulated were further validated vivo, studying...
Circulating tumor cells (CTCs), proposed as major players in cancer dissemination, have demonstrated clinical prognostic significance several types. However, their predictive value remains unclear. Here we evaluated the utility of six CTC markers (tissue specific and epithelial to mesenchymal transition transcripts) both tools metastatic colorectal (mCRC) patients. CTCs were immunoisolated from blood 50 mCRC patients at baseline 4 16 weeks after treatment onset. Expression levels GAPDH,...
Cell plasticity is emerging as a key regulator of tumor progression and metastasis. During carcinoma dissemination epithelial cells undergo to mesenchymal transition (EMT) processes characterized by the acquisition migratory/invasive properties, while reverse, (MET) process, also essential for metastasis outgrowth. Different transcription factors, called EMT‐TFs, including Snail, bHLH Zeb families are drivers EMT branch plasticity, can be post‐transcriptionally downregulated several miRNAs,...
Summary The International Prognostic Index (IPI) is the most widely used score for non‐Hodgkin lymphoma but lacks ability to identify a high‐risk population in diffuse large B‐cell (DLBCL). Low absolute lymphocyte count and high monocytes have proved be unfavourable factors. Red‐cell distribution width (RDW) has been associated with inflammation beta‐2 microglobulin (B2M) tumour load. retrospective study included 992 patients DLBCL treated R‐CHOP. In multivariate analysis, age, Eastern...
E12/E47 proteins (encoded by E2A gene) are members of the class I basic helix-loop-helix (bHLH) transcription factors (also known as E proteins). E47 has been described repressor E-cadherin and inducer epithelial-mesenchymal transition (EMT). We reported previously that EMT mediated in MDCK cells occurs with a concomitant overexpression Id1 Id3 proteins. Id belong to V HLH lack domain; they dimerise prevent their DNA interaction, thus, acting dominant negative Here, we show interacts...
Defining the mutational landscape of classic Hodgkin lymphoma is still a major research goal. New targeted next-generation sequencing (NGS) techniques may identify pathogenic mechanisms and new therapeutic opportunities related to this disease. We describe profile series 57 cHL cases, enriched in Reed-Sternberg (HRS) cells. Overall, results confirm presence strong genomic heterogeneity. However, several variants were consistently detected genes relevant signaling pathways, such as...
The regulation of ribosomal protein (RP) gene transcription is tightly linked to the nutrient status cell and under control metabolic signaling pathways. In Saccharomyces cerevisiae several transcriptional activators mediate efficient RP during logarithmic growth dissociate from promoters upon limitation. Repression appears be regulated predominantly by posttranslational modification cellular localization activators. We report here that one these factors, Sfp1, degraded proteasome activator...
Colorectal tumorigenesis is characterized by the sequential inactivation of a series tumor suppressor genes (microsatellite-stable tumors) and genetic or epigenetic alterations in mismatch repair nonpoliposic hereditary tumours 13% to 15% sporadic colorectal cancer [high microsatellite instability (MSI-H) tumors]. We hypothesized molecular mechanism for MSI-H tumors related matrix metalloproteinase 3 (MMP-3) promoter mutations, down-regulation MMP-3 expression, impairment MMP-9 activation....
Summary The management of recurrent/refractory (R/R) Hodgkin lymphoma ( HL ) remains challenging. Previously published data have shown some efficacy rituximab in this setting. purpose phase II trial was to investigate the activity ofatumumab combination with etoposide, steroids, cytarabine and cisplatin (O‐ ESHAP 62 patients R/R classical . Treatment consisted plus 1000 mg on days 1 8 first cycle day second third cycles. O‐ well tolerated only 3% requiring treatment discontinuation because...
Summary The Grupo Español de Linfomas y Trasplantes Médula Ósea International Prognostic Index ( GELTAMO ‐ IPI ) stratifies four risk groups in diffuse large B cell lymphoma DLBCL patients treated with immunochaemotherapy: low LR ), low‐intermediate LIR high‐intermediate HIR and high HR ). present study explores the effect of subtypes defined by immunohistochaemistry‐based Hans algorithm, Germinal Centre GCB non‐ . A multivariate Cox regression model including groups, origin COO their...
Diffuse large B-cell lymphoma (DLBCL) is an aggressive heterogeneous with standard treatment. However, 30%-40% of patients still fail, so we should know which are candidates for alternative therapies. IPI the main prognostic score but, in rituximab era, it cannot identify a very high-risk (HR) subset. The MD Anderson Cancer Center reported prerituximab era exclusively considering tumor-related variables: Tumor Score (TS). We aim to validate TS and analyze its current potential role.From...