A5024999759- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Body Contouring and Surgery
- Telomeres, Telomerase, and Senescence
- Esophageal Cancer Research and Treatment
- Metastasis and carcinoma case studies
- Obesity and Health Practices
- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Nutrition and Health in Aging
- Intestinal and Peritoneal Adhesions
- Eosinophilic Esophagitis
- Cardiovascular Disease and Adiposity
- Clinical Nutrition and Gastroenterology
- Cancer Research and Treatments
- Cardiovascular Function and Risk Factors
- Gastrointestinal disorders and treatments
- Colorectal Cancer Surgical Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Lung Cancer Treatments and Mutations
- Neurological and metabolic disorders
Universidad Complutense de Madrid
2006-2024
Hospital Clínico San Carlos
2015-2024
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2013-2024
Hospital Universitario de La Princesa
2023
Universidad Autónoma de Madrid
2023
Sociedad Española de Cirugía Ortopédica y Traumatología
2022
Comunidad de Madrid
2017
Saint Thomas Hospital
2016
This survey of international experts in obesity management was conducted to achieve consensus on standardized definitions and identify areas non-consensus metabolic bariatric surgery (MBS) assist an algorithm clinical practice guidelines for the obesity. A three-round Delphi with 136 statements by 43 comprising 26 surgeons, 4 endoscopists, 8 endocrinologists, 2 nutritionists, counsellors, internist, a pediatrician spanning six continents over 2-day meeting Hamburg, Germany. To reduce bias,...
Surgical resection with adequate lymphadenectomy is regarded the only curative option for gastric cancer. Regarding minimally invasive techniques, mainly Asian studies showed comparable oncological and short-term postoperative outcomes. The incidence of cancer lower in Western population patients often present more advanced stages disease. Therefore, reproducibility these results remains to be investigated.A randomized trial was performed thirteen hospitals Europe. Patients an indication...
Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) is a simplification of the duodenal switch (DS) in which alimentary limb eliminated, and common channel lengthened from 200 to 300 cm. Short-term results have demonstrated that SADI-S safe reproducible weight loss comorbidities resolution are comparable biliopancreatic diversion or DS.To analyze long-term outcomes SADI-S.From May 2007 December 2015, 164 patients were consecutively submitted one-step SADI-S. The mean age...
Adipocytes regulate blood vessel formation, and in turn endothelial cells promote preadipocyte differentiation through the expression of proangiogenic factors, such as vascular growth factor (VEGF)-A. Some adipocytokines hormones also have an effect on development.Our objectives were to analyze relationship between weight circulating VEGF-A morbidly obese subjects before after bariatric surgery, investigate certain regulating adipocytes.A total 45 women nine lean females included study....
Abstract BACKGROUND Telomere maintenance has been proposed as an essential step for tumor cell immortalization. The objectives of the current study were to investigate mechanisms implicated in telomere length colorectal carcinoma (CRC) and evaluate prognostic impact status. METHODS Ninety‐one samples that obtained from patients who underwent surgery analyzed factors related function. authors studied telomerase activity, terminal restriction fragment (TRF) length, telomeric‐repeat binding...
Abstract Obesity is a main global health issue and an outstanding cause of morbidity mortality predisposing to type 2 diabetes (T2DM) cardiovascular diseases. Huge research efforts focused on gene expression, cellular signalling metabolism in obesity have improved our understanding these disorders; nevertheless, bridge the gap between regulation expression changes signalling/metabolism, protein levels must be assessed. We extensively analysed visceral adipose tissue from age-, T2DM-...
Human age-related diseases, including obesity and type 2 diabetes (T2DM), have long been associated to mitochondrial dysfunction; however, the role for adipose tissue mitochondria in these conditions remains unknown. We tackled impact of aging T2DM on adipocyte from obese patients by quantitating not only corresponding abundance changes proteins, but also redox alterations undergone Cys residues thereof. For that, we resorted a high-throughput proteomic approach based isobaric labeling,...
Abstract Introduction Gastrointestinal anastomoses with classical sutures and/or metal staples have resulted in significant bleeding and leak rates. This multi-site study evaluated the feasibility, safety, preliminary effectiveness of a novel linear magnetic compression anastomosis device, Magnet System (MS), to form side-to-side duodeno-ileostomy (DI) diversion for weight loss type 2 diabetes (T2D) resolution. Methods In patients class II III obesity (body mass index [BMI, kg/m ] ≥ 35.0– ≤...
Comparison of diabetes remission rates after bariatric surgery using two different models criteria.Retrospective analysis data from 110 patients with type 2 and morbid obesity who underwent surgery, preoperatively at 18-month follow-up. remission: 1) 2009 consensus statement criteria; 2) simple criteria ADA's HbA1c diagnostic cut-off values.Patients' mean ± SD preoperative characteristics were: age 53.3 9.5 years, BMI 43.6 5.5 kg/m(2), 7.9 1.8%, duration 7.6 7.5 years. 44.5% previous insulin...
The role of telomeres and telomerase in colorectal cancer (CRC) is well established as the major driving force generating chromosomal instability. However, their potential prognostic markers remains unclear. We investigated outcome implications this tumour type. considered telomere length (TL), ratio to non-cancer tissue (T/N ratio), activity TERT levels; relation with clinical variables markers. analyzed 132 CRCs paired tissues. Kaplan-Meier curves for disease-free survival were calculated...
Abstract Background Type 2 diabetes ( T2D ) remission may be achieved after bariatric surgery BS ), but rates vary according to patients' baseline characteristics. The present study evaluates the relevance of several preoperative factors and develops statistical models predict 1 year . Methods We retrospectively studied 141 patients (57.4% women), with a diagnosis , who underwent in single center (2006–2011). Anthropometric glucose metabolism parameters before at 1‐year follow‐up were...