A5101949669- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gout, Hyperuricemia, Uric Acid
- Diet and metabolism studies
- Nutritional Studies and Diet
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Microbial Metabolism and Applications
- Pharmacological Effects of Natural Compounds
- Fatty Acid Research and Health
- Cardiovascular Disease and Adiposity
- Antioxidant Activity and Oxidative Stress
- Protein Hydrolysis and Bioactive Peptides
- Berberine and alkaloids research
- History and Politics in Latin America
- Consumer Attitudes and Food Labeling
- Cholesterol and Lipid Metabolism
- Nutrition, Genetics, and Disease
- Historical and Environmental Studies
- Health Systems, Economic Evaluations, Quality of Life
- Heart Rate Variability and Autonomic Control
- Nutrition and Health in Aging
- Peripheral Artery Disease Management
- Natural Antidiabetic Agents Studies
University of Bologna
2015-2024
Azienda USL di Bologna
2021-2024
Université Paris Cité
2013-2024
Sorbonne Paris Cité
2024
University of Turin
2016-2022
Policlinico S.Orsola-Malpighi
2008-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2020
Laboratoire ICT
2017
College of Slavonski Brod
2016
University of Zagreb
2016
Several epidemiological studies report a positive correlation between hyperuricemia and metabolic syndrome (MetS) in adults, which hyperuricemic subjects seem to more easily develop. We aimed verify if serum uric acid (SUA) concentrations were positively associated with MetS prevalence middle-term (4-year) incidence older overall healthy subjects. also purposed identify SUA cut-off values could be functional diagnosis addition the traditionally used parameters. For this reason, we selected...
The Beta-glucan Effects on Lipid profile, glycemia and inTestinal health (BELT) Study investigated the effect of 3 g/day oat beta-glucans plasma lipids, fasting glucose self-perceived intestinal well-being. was an 8-week, double-blind, placebo-controlled, cross-over randomized clinical trial, enrolling a sample 83 Italian free-living subjects, adherent to Mediterranean diet, with moderate hypercholesterolemia low cardiovascular risk profile. Beta-glucans reduced mean LDL-Cholesterol (LDL-C)...
North of Italy was severely hit by the COVID-19 (Coronavirus disease 19) pandemic. This induced government to adopt restrictive measures reduce contagion risk, forcing most population stop working and from leisure activities, remain at home for several weeks. Our study aimed evaluate effect COVID-related quarantine on smoking dietary habits a well-characterized northern Italian rural population. For this purpose, while lockdown restrictions were in place (February–April 2020), 359 subjects...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) circulating levels are significantly associated with an increased risk of cardiovascular events. This study aimed to evaluate the relationship between PCSK9 and arterial stiffness, early instrumental biomarker disease risk, in a large sample overall healthy participants.From historical cohort Brisighella Heart Study, after exclusion active smokers, participants secondary prevention for disease, patients treatment statins or vasodilating...
Previous evidence suggest that high low-density lipoprotein cholesterol (LDL-C) and serum uric acid (SUA) levels are risk factors for endothelial dysfunction vascular ageing. The aim of our study was to evaluate the short-term interaction between SUA, LDL-C incident hypertension in a sample overall healthy individuals.In January 2018, we selected from general database Brisighella Heart Study four groups age sex-matched nonhypertensive individuals with different SUA level examined during 2008...
Even though coffee consumption has been clearly related to a number of benefits the cardiovascular system, its effect on blood pressure (BP) not fully elucidated. In this sub-analysis Brisighella Heart Study (BHS), we compared central and peripheral BP values in sub-cohort 720 men (47.9%) 783 women (52.1%) reporting drinking different amounts each day, for whom full set clinical, laboratory hemodynamic parameters was available. According our observations, moderate associated either higher...
<b><i>Aim:</i></b> The aim of our study was to investigate whether treatment with red yeast rice added Coenzyme Q10 is associated changes in endothelial function and arterial stiffness. <b><i>Methods:</i></b> This double blind, placebo-controlled, randomized clinical trial carried out on 40 non-smoker moderately hypercholesterolemic subjects (ClinicalTrial.gov ID NCT02492464). After 4 weeks diet physical activity, patients were allocated...
Introduction: Polyunsaturated fatty acids (PUFAs) derived from different sources could have lipid-lowering effects in humans.The main aim of our study was to compare the short-term triglyceride-lowering efficacy krill oil and purified omega 3 ethyl ester PUFAs mildly overweight hypertriglyceridemic subjects.Material methods: This double-blind, randomized clinical trial carried out 25 moderately subjects (TG = 150-500 mg/ dl).After a 4-week run-in, participants were allocated treatment with...
Introduction: There is conflicting information linking fruit and fructose intake with cardiometabolic disorders. The main objective of our study was to evaluate the association between fruits sugar-sweetened beverages, carotid-femoral pulse wave velocity (cfPWV), a non-invasive marker arterial aging, in large population sample. Methods: For this study, we selected four age sex-matched subgroups from last Brisighella Heart Study survey, after exclusion those secondary prevention for...
Several studies claim that psychophysical stress and depression contribute significantly to cardiovascular disease (CVD) development. The aim of our research is discover analyse a possible relationship between two psychosocial disorders (depression perceived mental stress) traditional risk markers.We selected 106 subjects (58 males 48 females), mean age 79.5 +/- 3.8-years old, from the Massa Lombarda Project, an epidemiological study, including 7000 north Italian adult subjects. We carried...
Our aim was to test, through a crossover, double-blind, placebo-controlled randomized clinical trial, if short-term treatment with 10 mg monacolins combined antioxidants could improve lipid pattern, high-sensitivity C-reactive protein (hs-CRP), and endothelial function in small cohort of moderately hypercholesterolemic subjects. Thus, 25 healthy, subjects were consecutively enrolled and, after 4 weeks stabilization diet, the sequence placebo followed by washout, or placebo, each period being...
Overweight subjects easily develop alterations of the glucose and lipid metabolism are exposed to an increased cardiometabolic risk. This condition is potentially reversible through improvement dietary behavioural habits. However, a well-assembled nutraceutical would be useful tool better improve metabolic parameters associated overweight insulin resistance. To evaluate effect combined containing berberine, chlorogenic acid tocotrienols, we performed double blind, cross-over designed trial...
Serum cholesterol has been demonstrated to correlate with blood pressure values; therefore, abnormal levels of serum might contribute the development hypertension. The aim this study was assess new onset hypertension over a period 8 years in pharmacologically untreated population sample normo- and hypercholesterolemic individuals.1864 Caucasian subjects baseline values <140/90 mmHg were subdivided into two different groups, according LDL changes observed years. Group 1 included whose...
INTROduCTION Cardiovascular diseases are still the most common cause of death in developed countries. 1 The atherosclerotic process involves several oxidative reactions such as development oxygen and peroxyl radicals oxidation low-density lipoprotein (LDL) cholesterol, which is an important target free blood. 2 Oxidative burst innate immune response to infection, latter being also associated with marked changes lipid metabolism, aimed at neutralizing
Plant sterols are well-known natural lipid-lowering agents. The DESCO (Diet and plant in the control of cholesterolemia) study was a single-center, randomized, double-blind, placebo-controlled, two-way crossover clinical trial designed to investigate effect once-a-day ready-to-drink dietary supplement containing 2.5 g phytosterols on lipid profile, also relation quality diet, cohort 50 Italian individuals with polygenic hypercholesterolemia low global cardiovascular risk. Eligible were...
Abstract Aim The aim of this study was to evaluate and quantify the role different risk factors in long‐term development Type 2 diabetes mellitus a rural Italian population. Methods Brisighella Heart Study (BHS; 1972–2003) is prospective, population‐based longitudinal epidemiological cohort involving 2939 randomly selected subjects, aged 14–84 years, resident town Brisighella. For study, we 1441 adult subjects representative population; consecutively visited during three BHS surveys. A...
Contrasting data partially support a certain antihypertensive efficacy of lactotripeptides derived from enzymatic treatment casein hydrolysate. We carried out randomized, double-blind, crossover clinical study to investigate the short-term with in Mediterranean subjects normal or high-normal blood pressure (BP). consecutively enrolled 55 untreated (men:women = 30:25), 40.3 ± 9.8 years old, BP. After 4 weeks dietary standardization, they were allocated fruit juice containing 3 mg added...