A5075602342- Extracellular vesicles in disease
- Liver physiology and pathology
- Cell Adhesion Molecules Research
- Liver Disease Diagnosis and Treatment
- Proteoglycans and glycosaminoglycans research
- Fibroblast Growth Factor Research
- Cancer, Lipids, and Metabolism
- Research in Social Sciences
- Diet, Metabolism, and Disease
- Lipid metabolism and biosynthesis
- Social and Educational Sciences
- Venous Thromboembolism Diagnosis and Management
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- T-cell and Retrovirus Studies
- MicroRNA in disease regulation
- Viral Infections and Immunology Research
- Musculoskeletal synovial abnormalities and treatments
- Early Childhood Education and Development
- Cancer Cells and Metastasis
- Cardiovascular Disease and Adiposity
- Parvovirus B19 Infection Studies
University of Eastern Finland
2017-2025
Obesity is a worldwide epidemic characterized by adipose tissue (AT) inflammation. AT also source of extracellular vesicles (EVs) that have recently been implicated in disorders related to metabolic syndrome. However, our understanding mechanistic aspect obesity's impact on EV secretion from human remains limited.
Abstract Background Hyaluronic acid (HA) is the major extracellular matrix glycosaminoglycan with a reduced synovial fluid (SF) concentration in arthropathies. Cell-derived vesicles (EV) have also been proposed to contribute pathogenesis joint diseases. It has recently shown that human SF contains HA-coated EV (HA–EV), but their and function pathologies remain unknown. Methods The aim of present study was develop an applicable method based on confocal laser scanning microscopy (CLSM) image...
Abstract Background & aims We have previously reported that the serum levels of gut-derived tryptophan metabolite indole-3-propionic acid (IPA) are lower in individuals with liver fibrosis. Now, we explored transcriptome and DNA methylome associated IPA human from obese together effects on shifting hepatic stellate cell (HSC) phenotype to inactivation vitro. Methods A total 116 without type 2 diabetes (T2D) (age 46.8 ± 9.3 years; BMI: 42.7 5.0 kg/m ) Kuopio OBesity Surgery (KOBS) study...
Invasion of tumor cells through the stroma is coordinated in response to migratory cues provided by extracellular environment. One most abundant molecules microenvironment hyaluronan, a glycosaminoglycan known promote many hallmarks progression, including potential cells. Strikingly, hyaluronan also often found coat vesicles (EVs) that originate from plasma membrane tentacles crucial for migration, such as filopodia, and are niches. Thus, it possible hyaluronan-coated EVs have cooperative...
Extracellular vesicles (EVs) function as conveyors of fatty acids (FAs) and other bioactive lipids can modulate the gene expression behavior target cells. EV lipid composition influences fluidity stability membranes reflects availability mediator precursors. Fibroblast-like synoviocytes (FLSs) secrete EVs that transport hyaluronic acid (HA). FLSs play a central role in inflammation, pannus formation, cartilage degradation joint diseases, have recently emerged potential mediators these...
Abstract Background Orotic acid (OA) has been intensively utilized to induce fatty liver in rats. Although the capacity of OA cause steatosis is species-specific, previous vitro studies indicate that humans could also be susceptible OA-induced liver. The aim present study was re-elucidate potential exposure modulate cellular mechanisms involved both non-alcoholic disease pathogenesis and protection from lipid accumulation. In addition, alterations detailed (FA) profiles cells culture media...
Nonalcoholic fatty liver disease is among the most common diseases worldwide and one cause of cirrhosis that can result in development hepatocellular carcinoma (HCC). Hyaluronan (HA) a high-molecular-mass glycosaminoglycan with diverse functions tissue injury repair, for instance, inflammation fibrogenesis. The aim present study was to investigate relationships between HA synthesizing degrading enzymes spectrum pathologies. This realized by histological staining sections from controls...