Ziad Emarah
A5049325114- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Cancer Immunotherapy and Biomarkers
- Acute Myeloid Leukemia Research
- Neutropenia and Cancer Infections
- SARS-CoV-2 and COVID-19 Research
- Hematological disorders and diagnostics
- Multiple and Secondary Primary Cancers
- Long-Term Effects of COVID-19
- Inflammatory Biomarkers in Disease Prognosis
- Lymphoma Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Blood groups and transfusion
- Hematopoietic Stem Cell Transplantation
- COVID-19 Impact on Reproduction
- Nerve Injury and Rehabilitation
- Bone and Joint Diseases
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Breast Cancer Treatment Studies
- Virus-based gene therapy research
- Metabolism, Diabetes, and Cancer
Mansoura University
2018-2025
King Abdullah Medical City
2022-2024
Centre Hospitalier de Versailles
2023
University of Rijeka
2023
Azienda Usl Toscana Centro
2023
University of Belgrade
2023
Klinikum rechts der Isar
2023
University of Tabuk
2020
Molecular Oncology (United States)
2016-2019
Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics HM patients developing COVID-19 and analyzed predictors mortality. The survey was supported by the Scientific Working Group Infection Hematology European Association (EHA). Eligible analysis were adult laboratory-confirmed...
Patients with acute myeloid leukemia (AML) are at high risk of dying from coronavirus disease 2019 (COVID-19). The optimal management AML patients COVID-19 has not been established. Our multicenter study included 388 adult diagnosed between February 2020 and October 2021. vast majority were receiving or had received treatment in the preceding 3 months. was severe 41.2% critical 21.1% cases. chemotherapeutic schedule modified 174 (44.8%), delayed 68 permanently discontinued 106. After a...
BackgroundThe COVID-19 pandemic heightened risks for individuals with hematological malignancies due to compromised immune systems, leading more severe outcomes and increased mortality. While interventions like vaccines, targeted antivirals, monoclonal antibodies have been effective the general population, their benefits these patients may not be as pronounced.MethodsThe EPICOVIDEHA registry (National Clinical Trials Identifier, NCT04733729) gathers data from malignancy since pandemic's...
Genistein is a recognized isoflavone present in soybeans with antioxidant, anti-inflammatory, antiangiogenic and antitumor activities. This study aimed to test ability of genistein modulating versican/platelet derived growth factor (PDGF) axis HCC.HCC was experimentally induced male Sprague-Dawley rats then treated 25 or 75 mg/kg genistein. Antioxidant activities assessed by measuring the gene expression Nrf2 hepatic levels malondialdehyde (MDA), superoxide dismutase (SOD) reduced...
Abstract Background During the COVID-19 pandemic, individuals with hematological malignancies faced elevated risks, leading to increased hospitalization and mortality rates, despite availability of vaccines treatments for general population. Methods Data on cases in patients were collected from diverse global regions. This effort enabled compilation extensive epidemiological data a comprehensive analysis evolving patterns over three years. Results By December 2022, 8,767 reported among...
Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail.We analyzed elderly (age groups: 65-70, 71-75, 76-80, and >80 years old) included EPICOVIDEHA registry between January 2020 July 2022. Univariable multivariable Cox regression models were conducted to identify factors influencing death hematological malignancy.The study data from 3,603 (aged 65 or older) malignancy, a...
Background: Breast cancer in very young patients represents a unique issue that needs more attention as the number of cases is increasing and it has special characteristics at presentation, diagnosis, biologic behaviors which reflect on both treatment strategies survival. The aim current study was to analyze report clinico-pathological procedures used for breast over last decade single Egyptian center. Patients methods: A retrospective conducted Oncology Center – Mansoura University, where...
Patients affected by multiple myeloma (MM) have an increased risk of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection and subsequent (20)19 disease (COVID-19)-related death. The changing epidemiological therapeutic scenarios suggest that there has been improvement in severity survival COVID-19 during the different waves pandemic general population, but this not investigated yet MM patients. Here we analyzed a large cohort 1221 patients with confirmed SARS-CoV-2...
Since the beginning of COVID-19 pandemic, there has been an overall improvement in patient mortality. However, haematological malignancy patients continue to experience significant impacts from COVID-19, including high rates hospitalization, intensive care unit (ICU) admissions, and In comparison other patients, individuals with chronic myeloid leukemia (CML) generally have better prognosis. This study, conducted using a large database (EPICOVIDEHA), demonstrated that majority CML...
Fucoidan is sulfated polysaccharide of brown seaweed. It offers various pharmacological actions like anti-inflammatory, anti-bacterial and anti-tumor activities. Therefore, we aimed to investigate the effect targeting microRNA-143 inflammatory pathway by on experimentally induced hepatocellular carcinoma (HCC) in rats. HCC Sprague Dawley thioacetamide. Rats were treated with 100 mg/kg 200 Fucoidan. Hepatic sections stained hematoxylin/esosin for investigation cell integrity. Moreover,...
Febrile neutropenia (FN) is the evolution of fever in a patient with over 38.0°C. Neutropenia diagnosed when absolute neutrophil count (ANC) <1500 cells/µL. FN represents common complication cancer treatment. Hence, it featured to be major cause morbidity and mortality patients.
Background: The outcome of patients with simultaneous diagnosis haematological malignancies (HM) and COVID-19 is unknown there are no specific treatment guidelines. Methods: We describe the clinical features a cohort 450 HM registered in EPICOVIDEHA registry between March 2020 to February 2022. Results: Acute leukaemia lymphoma were most frequent (35.8% 35.1%, respectively). Overall, 343 (76.2%) received for HM, which was delayed longer than one month since 57 (16.6%). An overall response...
Abstract Background P D-L1 is expressed in tumor cells and plays a crucial role immune escape. Tumor-infiltrating lymphocytes (TILs) as CD8 T contribute to reduced growth. Few studies investigated the prognostic effect of PD-L1 TILs ovarian high-grade serous carcinoma (HGSC). In present study, we analyzed expression HGSC by immunohistochemistry, results were correlated prognosis. It was carried on 54 cases who attended Oncology Centre, Mansoura University, Egypt, from 2012 till 2019. Results...
Abstract : Background: The prevalence of Hepatitis C virus in Egypt reaches 15%, which is considered the highest world. Genotype 4 represents 93 % Egyptian HCV infections. Non-Hodgkin lymphoma (NHL) 5th most common cancer Egypt. association between infection and occurrence B-cell NHL well known while data are scarce Eastern countries. Objectives: We aimed to evaluate among patients with clinical characteristics associated Delta region (Mansoura-Egypt). Methods: Between March 2012 2013, 110...
Patients with colorectal cancer in different stages show variable outcomes/therapeutic responses due to their distinct tumoral biomarkers and biological features. In this sense, study aimed explore the prognostic utility of BRAF, programmed death-1 (PD1), its ligand (PDL1) protein signatures colon adenocarcinoma. The selected markers were explored 64 archived primary adenocarcinomas relation clinicopathological BRAF overexpression was found 39% cases significantly associated grade 3, N1,...
ABSTRACT Background: Investigation of new molecular markers expressed in colorectal carcinoma can help to select patients getting benefits from target therapeutic modalities. Aim: expression GLUT1 and ASCT2 carcinoma. Materials Methods: Sixty three resection specimens for cases diagnosed with were included the study. Full sections examined histopathological data including tumor type, grade, stage, lymphovascular invasion recorded. TMA blocks constructed immunostained polyclonal antibodies...
Microangiopathic hemolytic anemia (MAHA) may occur as a paraneoplastic syndrome in some solid tumors, but MAHA accompanied by signet ring cell carcinoma (SRCC) of an unknown origin is very rare. We report patient who presented with acute onset Coombs negative and frequent schistocytes the peripheral blood smear which are typical for initial presentation metastatic SRCC. Our patients fulfilled criteria thrombotic thrombocytopenic purpura (TTP) received specific treatment TTP without improvement.
Syndecan-1 (also known as SDC-1 or CD138) is a transmembrane proteoglycan that expressed in many hematological and solid tumors affects the prognosis of those cancers. We conducted this study to investigate prognostic role syndecan-1 acute leukemia. Forty cases de novo leukemia patients, 24 with myeloid (AML) 16 lymphoblastic (ALL), presented at Oncology Center Mansoura University, Mansoura, Egypt, follow-up period 26 months. was determined serum leukocytes by enzyme-linked immunosorbent...