<title>Abstract</title> Background Surface epithelial ovarian cancer (EOC) is the deadliest gynecological malignancy, mainly due to late-stage diagnosis and therapeutic resistance. Intratumoral heterogeneity, driven by stem cells (CSCs), contributes metastasis, recurrence, therapy Cluster of Differentiation 24 (CD24) has emerged as a promising biomarker linked tumor progression, immune evasion, but further research needed understand its role in progression patient outcomes. Aim This study...

Cases of primary neuroendocrine tumors in the liver combined with hepatocellular carcinoma are scarce. Such cases could present either as combined-type tumor or collision type.A 51-year-old man presented a mass right hemiliver. Serum level alpha-fetoprotein was slightly elevated (2.3ng/ml), normal CA19-9 and CA125. The patient underwent hepatectomy. resected specimen showed well-defined heterogeneous gray-white to brown friable tumor, 20cm diameter. Microscopically, consisted predominantly...

It was postulated that adriamycin (ADR) induce renal tubulointerstitial injury. Clinicians are faced with a challenge in producing response patients and slowing or halting the evolution towards kidney failure. The present study aimed at investigating relation between possible therapeutic effect of human mesenchymal stem cells (HMSCs), isolated from cord blood on tubular damage their distribution by using ADR induced nephrotoxicity as model albino rat.Thirty three male rats were divided into...

In this paper, a new approach for graphical enumeration of epicyclic gear mechanisms is presented using the concept acyclic graph. A code has been introduced to specify priorities all vertices associated displacement This used identify open graph, redundant links and isomorphic graphs. computer program developed automatic graphs as well detection with link without adjacency matrices. simplified methodology applied up 12-links having 9 coaxial links. An atlas 11 12-link constructed proposed...

Microangiopathic hemolytic anemia (MAHA) may occur as a paraneoplastic syndrome in some solid tumors, but MAHA accompanied by signet ring cell carcinoma (SRCC) of an unknown origin is very rare. We report patient who presented with acute onset Coombs negative and frequent schistocytes the peripheral blood smear which are typical for initial presentation metastatic SRCC. Our patients fulfilled criteria thrombotic thrombocytopenic purpura (TTP) received specific treatment TTP without improvement.

Abstract Objectives This study aimed at investigating the clinical significance of CEP78 and WDR62 in differentiated thyroid carcinoma (DTC). also finding predictors that help detecting patients with DTC who have high risk for lateral lymph node metastasis (LNM). Methods Quantitative real‐time polymerase chain reaction (RT‐qPCR) was performed to examine CEP78, mRNA expressions 40 tissue specimens DTC, goiter specimens. Additionally, we reviewed clinical, ultrasound, laboratory, pathological...

Glomerulosclerosis develops secondary to various kidney diseases. It was postulated that adriamycin (ADR) induce chronic glomerulopathy. Treatment combinations for one year did not significantly modify renal function in resistant focal segmental glomerulosclerosis (FSGS). Recurrence of FSGS after transplantation impacts long-term graft survival and limits access transplantation. The present study aimed at investigating the relation between possible therapeutic effect human mesenchymal stem...

Background: A clinical risk score has been introduced into the management of persistent trophoblastic disease to allow individualized therapy. However, this scoring system lacks histopathologic predictors. The hypothesis is that there are prognostic histological markers might contribute detection those cases will have disease. Methods: Trophoblastic proliferation and apoptosis were investigated via immunohistochemical expression Ki67 caspase in 24 complete moles. These divided two groups;...

Background:Most of thyroid carcinomas are papillary type. Gender difference in incidence suggests that such tumor might be influenced by sex hormones. HER 2/neu is known to play a role different types. This study aimed at assessing immunohistochemical expression estrogen receptors (ERs), progesterone (PRs), androgen (ARs) and Her 2/ neu carcinoma (PTC) its correlation with clinic-pathological parameters.Methods:This retrospective included 42 cases PTC. Clinic-pathological data were revised...

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is aggressive hematopoietic malignancy derived from the precursors of cells. The present study reported a case 35-year-old BPDCN patient, who presented with scalp lesions without extracutaneous involvement lymph nodes (LNs), peripheral or bone marrow. Histopathological examination lesion revealed monomorphous diffuse infiltrate small to medium-sized cells irregular nuclear contours, pleomorphic nuclei, finely dispersed chromatin,...

Reports of colonic adenocarcinoma with yolk sac tumor are rare. We reported a case 18 years-old female patient admitted to Mansoura oncology center severe abdominal pain. Physical examination revealed distended abdomen hepatomegaly no mass. Computed tomographic (CT) scan the markedly enlarged liver multiple innumerable variable sized hyper-echoic non-enhanced focal lesions. The underwent an ultrasound-guided biopsy that showed metastatic tumor. Colonoscopy confirmed large polypoidal...