A5042581942- Cynara cardunculus studies
- Cannabis and Cannabinoid Research
- Curcumin's Biomedical Applications
- Circadian rhythm and melatonin
- Botanical Research and Applications
- Neonatal Respiratory Health Research
- Prenatal Substance Exposure Effects
- Retinal Diseases and Treatments
- Birth, Development, and Health
- NF-κB Signaling Pathways
- S100 Proteins and Annexins
- Paraoxonase enzyme and polymorphisms
- Toxoplasma gondii Research Studies
- Genomics, phytochemicals, and oxidative stress
- Asthma and respiratory diseases
- Chemokine receptors and signaling
- Complement system in diseases
- Algal biology and biofuel production
- Thyroid Cancer Diagnosis and Treatment
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Autophagy in Disease and Therapy
- Herpesvirus Infections and Treatments
- Hibiscus Plant Research Studies
- Genetic factors in colorectal cancer
Mansoura University
2019-2024
Almaarefa University
2021-2024
Alfaisal University
2021-2024
Diabetic retinopathy (DR) is a debilitating diabetic disorder of the retinal microvasculature and main cause avoidable blindness in old people. Hesperetin plant flavanone largely abundant citrus species with neuroprotective properties animal models. This study aimed to explore autophagy-enhancing effect hesperetin rats DR. Twenty-four male were utilized allocated groups: (i) vehicle group, (ii) DR group (iii–iv) + (50 100 mg/kg) groups. Treatment continued for 6 weeks. After euthanized,...
Introduction: Betanin (C₂₄H₂₆N₂O₁₃) is safe to use as food additives approved by the FDA with anti-inflammatory and anticancer effects in many types of cancer cell lines. The current experiment was designed test chemotherapeutic effect combination betanin standard agent, capecitabine, against chemically induced colon mice. Methods: Bioinformatic approach get information about possible mechanisms through which drugs may control development. Five groups mice were assigned as, (i) saline, (ii)...
Introduction: Parkinson’s disease (PD) is a neurologic condition exhibiting motor dysfunction that affects old people. Marula oil (M-Oil) has been used longley in cosmetics and curing skin disorders. M-Oil particularly stable due to its high concentration of monounsaturated fatty acids natural antioxidants. The current study formulated an o/w nanoemulsion (M-NE) preparations tested anti-inflammatory antioxidant actions against experimental parkinsonism. Methods: Four groups male albino mice...
Abstract Toxoplasma gondii is a worldwide prevalent parasite. The infection has been linked to variable inflammatory effects including neuroinflammation. Biochanin A (BCA) an isoflavone, known for its anti-inflammatory and anti-oxidative properties. In this study, we examined the effect of BCA on brain liver lesions in murine model with chronic toxoplasmosis. Mice were divided six groups: non-infected control, BCA-treated, four infected groups Me49-type II cystogenic strain: (50...
Abstract Objectives This study aimed at investigating the clinical significance of CEP78 and WDR62 in differentiated thyroid carcinoma (DTC). also finding predictors that help detecting patients with DTC who have high risk for lateral lymph node metastasis (LNM). Methods Quantitative real‐time polymerase chain reaction (RT‐qPCR) was performed to examine CEP78, mRNA expressions 40 tissue specimens DTC, goiter specimens. Additionally, we reviewed clinical, ultrasound, laboratory, pathological...
The expression of the main cannabinoid receptors (CBR1 and CBR2) was investigated to evaluate possible association with sperm maturation from fertile infertile individuals. One hundred subjects were classified into (n = 50) groups 50). Fresh semen samples collected. Computer-assisted analysis acrosin activity test done. RNA extracted mature immature pellets. Reverse transcriptase reaction real-time PCR done assess levels both CBR1 CBR2 genes in all samples. Mature spermatozoa showed...
Leflunomide (LFND) is an immunosuppressive and immunomodulatory disease-modifying antirheumatic drug (DMARD) that was approved for treating rheumatoid arthritis. LFND-induced cardiotoxicity not fully investigated since its approval. We the cardiac injury in male mice identified role of nuclear factor erythroid 2-related 2/nuclear factor-κ B (Nrf2/NF-κB) signaling. Male albino were assigned into five groups as control, vehicle, LFND (2.5, 5, 10 mg/kg). enzymes, histopathology, mRNA expression...
Bronchial asthma is a common chronic inflammatory disease affecting the airway. Cytokines have pivotal role in regulation of immune response, and development asthma. Interleukin 33 newly discovered member cytokines, belongs to interleukin 1 family. Previous studies reported that expression IL33 associated with bronchial This study aimed evaluate prevalence (IL33) single nucleotide polymorphism (SNP) rs1929992 asthmatic patients determine relation IL33SNP serum level. The Results RFLP were...
Background: Coronary heart disease (CHD) is the leading cause of morbidity and mortality worldwide.There are many risk factors for CHD but recently role oxidative stress in progression atherosclerosis has been more recognized.Paraoxonase 1 (PON1) protects against oxidation LDL polymorphisms both exons promoter regions gene have investigated their association with CHD.The aim present study was to investigate relation between suceptibility PON1 Q192R (A/G) polymorphism a cohort Egyptian...
Aims & Objectives: To evaluate acute respiratory distress syndrome (ARDS)-related changes in serum melatonin levels critically ill children PICU. Methods: An observational prospective study carried out PICU at Mansoura University Children’s Hospital, Egypt, from October 2017 to 2018. 28 diagnosed as ARDS with age distribution ranging 1.5 168 months. Patients were recruited consecutively subdivided into two groups; 13 patients criteria of and 15 controls without ARDS. All subjected...
CX3CL1-CX3CR1 pathway may be one of the future treatment targets to delay progression end-stage renal diseases. This study aimed evaluate CX3CR gene polymorphism in Egyptian patients with ESRD and its relation fractalkine blood level. The included 100 on dialysis, 61 males 39 females mean age 51.02 ± 7.8 years. V2491 genotype revealed a significant increase frequency GG healthy control (83%) compared [69%] GA [30%] subjects [15%], <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1">...