A5004195981- Streptococcal Infections and Treatments
- Tryptophan and brain disorders
- Drug-Induced Hepatotoxicity and Protection
- Stress Responses and Cortisol
- Nicotinic Acetylcholine Receptors Study
- Pharmacogenetics and Drug Metabolism
- Curcumin's Biomedical Applications
- Genomics, phytochemicals, and oxidative stress
- Endoplasmic Reticulum Stress and Disease
- Cannabis and Cannabinoid Research
- Cancer Immunotherapy and Biomarkers
- Forensic Anthropology and Bioarchaeology Studies
- Parkinson's Disease Mechanisms and Treatments
- Potato Plant Research
- Immunotherapy and Immune Responses
- Cancer therapeutics and mechanisms
- Urologic and reproductive health conditions
- Liver physiology and pathology
- Veterinary Pharmacology and Anesthesia
- TGF-β signaling in diseases
- Toxoplasma gondii Research Studies
- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Nitrogen and Sulfur Effects on Brassica
- IgG4-Related and Inflammatory Diseases
Mansoura University
2017-2023
Yarmouk University
2021-2023
Jordan University of Science and Technology
2023
There are many RNA polymerase inhibitors, such as rifampicin, which acts an antituberculosis agent, and relatively new antiviral drugs, sofosbuvir. These drugs have a safe profile strong efficacy in treating tuberculosis hepatitis C infections. Studies shown that high doses of these compounds promote cell longevity (prolonging life span) humans. It is hypothesized also affect human polymerases at doses. We predicted inhibition inhibits the transcription machinery, considered pacemaker...
Introduction: Parkinson’s disease (PD) is a neurologic condition exhibiting motor dysfunction that affects old people. Marula oil (M-Oil) has been used longley in cosmetics and curing skin disorders. M-Oil particularly stable due to its high concentration of monounsaturated fatty acids natural antioxidants. The current study formulated an o/w nanoemulsion (M-NE) preparations tested anti-inflammatory antioxidant actions against experimental parkinsonism. Methods: Four groups male albino mice...
Antibiotic abuse is a common phenomenon in Egypt as medications are prescribed without supervision. It suggested that the excess use of antibiotics modifies gut microbiota and plays role development neurological psychiatric disorders.The aim present study was to bulb-c mice models for curam (amoxicillin /clavulanic acid) compared locally acting neomycin model, then restoring probiotic balance look at possible effects on animal brains.The results showed early excitable brains demonstrated by...
Diffuse large B cell lymphoma is the most common type of in Egypt with an unfavorable prognosis. The tumor microenvironment rich immune response either T cells or macrophages. current study aimed at testing CD4, CD8, CD68, and MMP9 immunohistochemistry DLBCL activities prognosis tumor. results showed no positive relation between macrophage reaction to suggesting that this part process not a defense mechanism from surrounding stroma.
Recent studies indicated renal toxicity and interstitial nephritis in patients receiving leflunomide (LEFN), but the exact mechanism is still unknown. The transforming growth factor β (TGFβ)/p53/Smad2/3 pathway crucially mediates fibrosis. We aimed to assess nephrotoxic effect of LEFN mice possible role TGFβ-stimulated p53/SMAD2/3 signaling. study design involved distributing sixty male albino into four groups: (i) vehicle-treated mice, (ii) (2.5 mg/kg), (iii) (5 (iv) (10 mg/kg). drug was...
Introduction: Male factor is responsible for about half of infertility problems.However, the reasons decrease in male fertility are still broadly unclear.The mechanisms how smoking may impact have not been established.However, with its influence on different semen parameters, it regarded as a risk infertility.Aim: To investigate effect chronic spermatozoa NRF2 expression and DNA fragmentation infertile men apparently normal seminogram to determine if markers could be possible predictors...
Introduction: Pterygium is a common ophthalmic problem in the Middle East where exposures to dust and sun rays are risk factors. The condition more prevalent middle-aged males can be considered as an aging process. aim of this study test both degenerative proliferative components by reduced glutathione topoisomerase one activity. Methods: applied immunohistochemistry staining for 1. Results: samples expressed positive most primary conditions all secondary Pterygium. On other hand, 1 focal...
Background: The determination of age and sex is crucial for establishing human identity. Themandible an accessible durable bone that very useful in this respect.Aim: To assess the efficacy measuring mandible ramus length identification ageand a group Egyptians.Subjects Methods: was measured lateralcraniofacial scans 213 individuals (99 males 114 females) with range 7-58 yearsusing cone-beam computerized tomography (CBCT).Results: Sexual dimorphism not observed until 17 years sample. There...
Objective: The aim was to evaluate different aspects related early male circumcision, community awareness, and family satisfaction. Methods: A questionnaire-based survey conducted with the following items on circumcision; time, technique, performing medical practitioner, where circumcision conducted. Alongside, other questions regarding satisfaction cases needing redo were also included in questionnaire. Results: number of participants 1,118. Timing most commonly neonatal period, first year...
Abstract Low toxic doses of tramadol induced animal brain cortex apoptosis and hippocampus injury. Adding nicotine reverted pathological changes without triggering The expression CHOP protein in real-time PCR showed mild Endoplasmic reticulum stress (ER) rats’ brains. Histological, immunohistochemical, western blotting analysis BIP chaperones demonstrated liver tissue samples. Furthermore, the levels autophagy markers a increase. Nicotine relatively decreasedbrain ER stress. combined profile...
Sudden death is unanticipated, non-violent taking place within the first 24 h after onset of symptoms. It a major public health problem worldwide. Moreover, effects living at moderate altitude on mortality are poorly understood.To retrospectively report frequency and main causes sudden deaths in relation to total Asir Central Hospital, 2255 m above sea level, southern region Saudi Arabia over period 4 years from 2013 2016.The medical records 1821 were examined showed 353 cases (19.4%)...
Abstract Background: Tramadol is a substance of abuse in the Middle East, and smoking extremely common among population. Methods: An experimental study was performed on Sprague Dawley rats to explore effect both nicotine tramadol liver testes. administered at 10 mg/kg 20 testes, respectively, while 125 mcg/kg. Western blot analysis BIP (immunoglobulin heavy-chain binding protein) CHOP (CCAAT-enhancer-binding protein homologous revealed that fewer problems were induced by adding . Conclusions...
Tramadol abuse is a common problem in the Middle East conjunction with smoking. The current study applied immunohistochemistry, western blot, real-time PCR, and ELISA to test combination toxicity. Low toxic doses of tramadol induced animal brain cortex inflammation hippocampus injury. Adding nicotine reverted pathological changes without triggering marked expression CHOP protein PCR showed mild endoplasmic reticulum stress (ER) rat's brain. Histological, immunohistochemical, blotting...
Suicide represents a major health problem, it is suggested that multiple factors influence the rate of suicide.Brain derived neurotrophic factor (BDNF) considered reliable biological marker suicide.Its level decreases in all suicidal victims whether or not they are suffering from psychiatric troubles.The objective this work was to compare BDNF levels and single nucleotide polymorphism non-suicidal groups explore suicide related mechanisms.Plasma were screened conjunction with tracking 196...
In order to studying the influence of foliar spray with different NPK levels (0.0, 1.0, 1.5 and 2.0 g/ l) as main factor tap water, dry yeast(Y)at 0.5g/ l, ascorbic acid (AA) at 150 ppm l Y+150 AA sub well their interaction treatments on Arabian jasmine var.Double petals, a pot experimental study was conducted during 2016 2017 seasons Floriculture Unit Hort.Dept., Fac.Agric., Mansoura Univ., Egypt.These (4×4) were arranged in split-plot design three replications.The obtained results revealed...