Darko Antić
A5037966102- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Immunodeficiency and Autoimmune Disorders
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Viral-associated cancers and disorders
- CNS Lymphoma Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Blood Coagulation and Thrombosis Mechanisms
- Multiple Myeloma Research and Treatments
- Advanced Breast Cancer Therapies
- COVID-19 Clinical Research Studies
- Hematological disorders and diagnostics
- COVID-19 and healthcare impacts
- Glioma Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Platelet Disorders and Treatments
- Central Venous Catheters and Hemodialysis
- Chronic Myeloid Leukemia Treatments
- Blood groups and transfusion
- Angiogenesis and VEGF in Cancer
- Vascular Tumors and Angiosarcomas
- Monoclonal and Polyclonal Antibodies Research
- Hemophilia Treatment and Research
University of Belgrade
2016-2025
Univerzitetski Klinički Centar Srbije
2009-2025
Centar za Promociju Nauke
2014-2023
Center for Health, Exercise and Sport Sciences
2015-2023
University of Belgrade – Faculty of Medicine
2022
Loyola University Medical Center
2020
Centre of Research Excellence in Nutrition and Metabolism
2018
Mount Vernon Cancer Centre
2011
Hospital Santa Marcelina
2011
Hospital São Paulo
2011
Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics HM patients developing COVID-19 and analyzed predictors mortality. The survey was supported by the Scientific Working Group Infection Hematology European Association (EHA). Eligible analysis were adult laboratory-confirmed...
Thrombosis is one of the most frequent complications cancer, with a potential impact on morbidity and mortality, particularly those acute myeloid leukemia (AML). Therefore, effective thrombosis prevention crucial aspect cancer management. However, preventive measures against may carry inherent risks complications. Consequently, application should be limited to patients reasonable risk developing thrombosis. This thesis explores data science (DS) methods for predicting venous in leukemia. In...
Abstract Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due age, disease, and treatment-related immunosuppression. We aimed assess risk factors of outcome elucidate the impact CLL-directed treatments on course COVID-19. conducted a retrospective, international study, collectively including 941 patients CLL confirmed Data from beginning pandemic until March 16, 2021, were collected 91 centers. The case fatality rate (CFR),...
Lymphoma patients are at increased risk of thromboembolic events but thromboprophylaxis in these is largely underused. We sought to develop and validate a simple model, based on individual clinical laboratory patient characteristics that would designate lymphoma for event. The study population included 1,820 who were treated the Departments Clinics Hematology, Clinical Center Serbia Kragujevac. model was developed using data from derivation cohort (n = 1,236), further assessed validation...
Abstract Background Patients with acute myeloid leukemia (AML) are at increased risk of venous thromboembolic events (VTE). However, thromboprophylaxis is largely underused. Objectives This study aimed to determine possible VTE development factors and develop a novel predictive model. Methods We conducted retrospective cohort adult patients newly diagnosed AML. used univariate multivariable logistic regression estimate binary outcomes identify potential predictors. Based on our final model,...
We evaluated coagulation abnormalities via traditional tests and rotational thromboelastometry (ROTEM) in a group of 94 patients with confirmed SARS-CoV-2 infection different severity pneumonia (34 moderate, 25 severe, 35 critical) the hypothesis that ROTEM parameters differed by coronavirus disease 2019 (COVID-19) severity. Shorter than normal clotting time (CT) higher maximum clot firmness (MCF) extrinsic (EXTEM) fibrinogen (FIBTEM), shorter EXTEM formation (CFT), α-angle were classified...
Abstract In this retrospective international multicenter study, we describe the clinical characteristics and outcomes of patients with chronic lymphocytic leukemia (CLL) related disorders (small lymphoma high‐count monoclonal B lymphocytosis) infected by SARS‐CoV‐2, including development post‐COVID condition. Data from 1540 CLL SARS‐CoV‐2 January 2020 to May 2022 were included in analysis assigned four phases based on cases disposition variants emergence. Post‐COVID condition was defined...
Long non-coding RNAs (lncRNAs) play complex roles at multiple levels of gene regulation, thus modulating key cellular processes involved in the pathogenesis and progression cancer. Aberrant expression lncRNAs has been reported various malignancies, including chronic lymphocytic leukemia (CLL). We investigated lnc-IRF2-3 lnc-KIAA1755-4 peripheral blood mononuclear cells 112 previously untreated CLL patients by quantitative reverse-transcriptase polymerase chain reaction. Both were found to be...
Thrombosis is a critical complication in lymphomas, driven by chronic inflammation. To observe this systemic mechanism, we evaluated inflammatory cytokines, neutrophil and monocyte activation, platelet function diffuse large B-cell lymphoma (DLBCL), follicular (FL), Hodgkin (HL), with without thrombosis using ELISA flow cytometry according to laboratory clinical data. Interleukin-1β was elevated across lymphomas inversely correlated the Khorana score for venous thromboembolism, while...
Abstract Background One year after the declaration of coronavirus disease 2019 (COVID-19) pandemic by World Health Organization (WHO) and despite implementation mandatory physical barriers social distancing, humanity remains challenged a long-lasting devastating public health crisis. Management Non-pharmacological interventions (NPIs) are efficient mitigation strategies. The success these NPIs is dependent on approval commitment population. launch mass vaccination program in many countries...
The existence of a potential primary central nervous system lymphoma-specific genomic signature that differs from the systemic form diffuse large B cell lymphoma (DLBCL) has been suggested, but is still controversial. We investigated 19 patients with DLBCL (DLBCL CNS) using TruSeq Amplicon Cancer Panel (TSACP) for 48 cancer-related genes. Next generation sequencing (NGS) analyses have revealed over 80% potentially protein-changing mutations were located in eight genes (CTNNB1, PIK3CA, PTEN,...
Abstract Background Lymphomas are characterized by elevated synthesis of inflammatory soluble mediators that could trigger the development venous thromboembolism (VTE). However, data on relationship between specific immune dysregulation and VTE occurrence in patients with lymphoma scarce. Therefore, this study aimed to assess association markers risk lymphoma. Methods The erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR),...
Purpose: We sought to investigate whether B cell receptor immunoglobulin (BcR IG) stereotypy is associated with particular clinicobiological features among chronic lymphocytic leukemia (CLL) patients expressing mutated BcR IG (M-CLL) encoded by the IGHV4-34 gene, and also ascertain these associations could refine prognostication.Experimental Design: In a series of 19,907 CLL cases available immunogenetic information, we identified 339 IGHV4-34-expressing assigned one four largest stereotyped...