A5035515667- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Acute Lymphoblastic Leukemia research
- Hematological disorders and diagnostics
- Blood groups and transfusion
- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- COVID-19 Clinical Research Studies
- Neutropenia and Cancer Infections
- Hematopoietic Stem Cell Transplantation
- Protein Degradation and Inhibitors
- Blood properties and coagulation
- Lymphoma Diagnosis and Treatment
- Bone and Joint Diseases
- Multiple Myeloma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Renal and related cancers
- COVID-19 and healthcare impacts
- Vascular anomalies and interventions
- Telomeres, Telomerase, and Senescence
- Retinal Diseases and Treatments
- Complement system in diseases
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
University of Belgrade
2011-2025
Univerzitetski Klinički Centar Srbije
2008-2025
Center for Health, Exercise and Sport Sciences
2023
Centar za Promociju Nauke
2011-2021
University of Belgrade – Faculty of Medicine
2021
Thrombosis is one of the most frequent complications cancer, with a potential impact on morbidity and mortality, particularly those acute myeloid leukemia (AML). Therefore, effective thrombosis prevention crucial aspect cancer management. However, preventive measures against may carry inherent risks complications. Consequently, application should be limited to patients reasonable risk developing thrombosis. This thesis explores data science (DS) methods for predicting venous in leukemia. In...
Abstract Background Patients with acute myeloid leukemia (AML) are at increased risk of venous thromboembolic events (VTE). However, thromboprophylaxis is largely underused. Objectives This study aimed to determine possible VTE development factors and develop a novel predictive model. Methods We conducted retrospective cohort adult patients newly diagnosed AML. used univariate multivariable logistic regression estimate binary outcomes identify potential predictors. Based on our final model,...
We evaluated coagulation abnormalities via traditional tests and rotational thromboelastometry (ROTEM) in a group of 94 patients with confirmed SARS-CoV-2 infection different severity pneumonia (34 moderate, 25 severe, 35 critical) the hypothesis that ROTEM parameters differed by coronavirus disease 2019 (COVID-19) severity. Shorter than normal clotting time (CT) higher maximum clot firmness (MCF) extrinsic (EXTEM) fibrinogen (FIBTEM), shorter EXTEM formation (CFT), α-angle were classified...
Introduction: The treatment of acute myeloid leukemia (AML) is accompanied by infectious complications, particularly during induction. surge multi-drug resistant (MDR) bacteria represents an additional problem for the health care patients with AML. Methodology: A retrospective analysis complications was performed in 84 AML undergoing induction therapy hospitalized between October 2020 and April 2023 at Clinic Hematology, University Clinical Centre Serbia. Results: From 95 bacterial isolates,...
The objective of this single-center study was to determine the pretreatment risk factors and influence comorbidity on outcome in patients with acute myeloid leukemia (AML). research involved 145 AML during a 58-month follow-up period. results suggest that most significant predictor poor overall survival (OS) is an adverse karyotype (P = 0.007), while for rate complete remission (CR) it age ≥55 years, early death comorbidity, as scored by Hematopoetic Cell Transplantation Comorbidity Index...
Abstract Examination of central nervous system (CNS) involvement is not routine diagnostic practice in adult patients with acute myeloid leukemia (AML). Therefore, many asymptomatic CNS might go undetected. The effect on the AML disease course well defined, conflicting results regarding clinical outcome. This study aimed to determine incidence estimated by multiparametric flow cytometry cerebrospinal fluid (MFC‐CSF) at diagnosis, related potential risk factors, and prognosis. In total, 645...
Abstract Background Mutations in the isocitrate dehydrogenase 1 and 2 ( IDH1 IDH2 ) genes are frequent molecular lesions acute myeloid leukaemia with normal karyotype (AML-NK). The effects of IDH mutations on clinical features treatment outcome AML-NK have been widely investigated, but only a few studies monitored these during follow-up. Patients methods In our study samples from 110 adult de novo were studied for presence mutations, their associations other prognostic markers disease...
The study included 48 untreated patients with monoclonal gammopathies (MG). Paraprotein was isolated from the serum of 10 decreased platelet aggregation. Platelet aggregation measured before and after addition paraprotein to platelet-rich plasma (PRP) healthy donors, in vitro. Expression von Willebrand factor (vWF) receptor glycoprotein (GP)Ib collagen GPVI determined by flow cytometry PRP donors using antibodies, CD42b (for GPIb) CD36 GPVI). Flowcytometry showed that expression positive...
Background: Cytarabine-anthracycline-based induction chemotherapy remains the standard of care for remission among patients with newly diagnosed acute myeloid leukaemia (AML). There are remarkable differences in therapy response AML patients. This fact could be partly explained by patients' genetic variability related to metabolic paths cytarabine and anthracyclines. study aims evaluate effect variants pharmacogenes SLC29A1, DCK, ABCB1, GSTM1, GSTT1, as well laboratory AML-related parameters...
Abstract Introduction Patients with acute promyelocytic leukemia (APL) are characterized by the highest expression of Wilms' tumor 1 ( WT1 ) gene compared other subtypes myeloid leukemia, and yet this molecular marker is almost never used for risk stratification in therapy response monitoring. Methods Quantitative assessment transcripts was performed using real‐time PCR method. The bone marrow samples were collected at time diagnosis 47 APL patients, 31/47 patients during follow‐up/relapse...
There are limited data on the impact of severe acute respiratory syndrome corona virus 2 infection in patients previously diagnosed with primary immune thrombocytopenia (ITP) thrombopoietin receptor agonist therapy (TPO-RA). Seven chronic ITP who had contracted COVID-19 and been treated TPO-RA included study. Demographic, treatment comorbidities were collected retrospectively from patients' medical records. Data regarding clinical course prospectively. During infection, all platelet count...
Patients with hematological malignancies have an increased risk of arterial thrombotic events (ATEs) after diagnosis, compared to matched controls without cancer. However, data about incidence and factors for ATE development in patients acute myeloid leukemia (AML) are missing.The objectives this study were determine the non-promyelocytic-AML define potential development.We conducted a retrospective cohort adult newly diagnosed AML. The primary outcome was occurrence confirmed ATE, defined...
Introduction: To assess incidence and mortality trends of acute myeloid leukemia (AML) in Belgrade (Serbia) a 15-year period (from 1999 to 2013). Material Methods: Data were obtained from the Cancer Registry Serbia, Institute Public Health Serbia. Standardized rates per 100,000 inhabitants calculated by direct standardization method using World Standard Population. Analysis raw data indicated single-digit numbers year 5-year age cohorts. Therefore, we merged years diagnosis three-year...
Based on current findings, the presence of NPM1 mutations in acute myeloid leukemia (AML) patients is associated with an increased probability complete remission (CR) and better overall survival (OS). We determined incidence prognostic relevance mutations, their association FLT3 IDH other clinical characteristics Serbian adult AML patients. Samples from 111 de novo patients, including 73 cases a normal karyotype (NK-AML), were studied. NPM1, FLT3, detected by PCR direct sequencing. 22.5% The...