A5078936456- Acute Myeloid Leukemia Research
- Platelet Disorders and Treatments
- Blood groups and transfusion
- Retinoids in leukemia and cellular processes
- Venous Thromboembolism Diagnosis and Management
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Lysosomal Storage Disorders Research
- Acute Lymphoblastic Leukemia research
- Lung Cancer Research Studies
- Blood Coagulation and Thrombosis Mechanisms
- COVID-19 and healthcare impacts
- Lung Cancer Treatments and Mutations
- SARS-CoV-2 and COVID-19 Research
- Blood properties and coagulation
- Bone and Joint Diseases
- Chronic Lymphocytic Leukemia Research
- Ovarian cancer diagnosis and treatment
- Complement system in diseases
- Lymphoma Diagnosis and Treatment
- Trypanosoma species research and implications
- Cancer Treatment and Pharmacology
- Hematological disorders and diagnostics
- Blood disorders and treatments
- Studies on Chitinases and Chitosanases
University of Belgrade
2016-2025
Univerzitetski Klinički Centar Srbije
2012-2025
Zemun Hospital
2024
University of Belgrade – Faculty of Medicine
2021-2023
Center for Health, Exercise and Sport Sciences
2023
Centar za Promociju Nauke
2011-2021
GTx (United States)
2021
University Hospital Innsbruck
2013
Pierre Fabre (France)
2004-2006
Groote Schuur Hospital
2006
Thrombosis is one of the most frequent complications cancer, with a potential impact on morbidity and mortality, particularly those acute myeloid leukemia (AML). Therefore, effective thrombosis prevention crucial aspect cancer management. However, preventive measures against may carry inherent risks complications. Consequently, application should be limited to patients reasonable risk developing thrombosis. This thesis explores data science (DS) methods for predicting venous in leukemia. In...
Abstract Background Patients with acute myeloid leukemia (AML) are at increased risk of venous thromboembolic events (VTE). However, thromboprophylaxis is largely underused. Objectives This study aimed to determine possible VTE development factors and develop a novel predictive model. Methods We conducted retrospective cohort adult patients newly diagnosed AML. used univariate multivariable logistic regression estimate binary outcomes identify potential predictors. Based on our final model,...
We evaluated coagulation abnormalities via traditional tests and rotational thromboelastometry (ROTEM) in a group of 94 patients with confirmed SARS-CoV-2 infection different severity pneumonia (34 moderate, 25 severe, 35 critical) the hypothesis that ROTEM parameters differed by coronavirus disease 2019 (COVID-19) severity. Shorter than normal clotting time (CT) higher maximum clot firmness (MCF) extrinsic (EXTEM) fibrinogen (FIBTEM), shorter EXTEM formation (CFT), α-angle were classified...
Abstract Despite enormous improvement in the management of patients with acute promyelocytic leukemia (APL), distinctive coagulopathy observed at presentation affected is often life-threatening. While hemorrhagic manifestations are well known and described this setting, APL-related thromboses underappreciated. Data regarding complication scarce showing variable incidence. Furthermore, risk factors for thrombosis inconsistent unreliable; so, differentiation increased hemorrhage from an...
Introduction: The treatment of acute myeloid leukemia (AML) is accompanied by infectious complications, particularly during induction. surge multi-drug resistant (MDR) bacteria represents an additional problem for the health care patients with AML. Methodology: A retrospective analysis complications was performed in 84 AML undergoing induction therapy hospitalized between October 2020 and April 2023 at Clinic Hematology, University Clinical Centre Serbia. Results: From 95 bacterial isolates,...
Molnupiravir and nirmatrelvir/ritonavir are antivirals used to prevent progression severe SARS-CoV-2 infections decrease hospitalisation mortality rates. Nirmatrelvir/ritonavir was authorised in Europe December 2021, whereas molnupiravir is not yet licensed as of February 2022. may be an alternative because it associated with fewer drug-drug interactions contraindications. A caveat for the mode action induces viral mutations. Mortality rate reduction less pronounced than that patients...
Abstract Examination of central nervous system (CNS) involvement is not routine diagnostic practice in adult patients with acute myeloid leukemia (AML). Therefore, many asymptomatic CNS might go undetected. The effect on the AML disease course well defined, conflicting results regarding clinical outcome. This study aimed to determine incidence estimated by multiparametric flow cytometry cerebrospinal fluid (MFC‐CSF) at diagnosis, related potential risk factors, and prognosis. In total, 645...
In the Balkans, rising concerns about invasive fungal infections over past decade stem from various factors. Primarily, there has been a notable uptick in immunocompromised individuals, including those with chronic illnesses like immunological and hematological diseases. Thus, it is essential to assess region's laboratory capabilities availability of antifungals. This evaluation vital for gauging preparedness diagnose treat effectively, thus minimizing their public health impact.
Abstract Background Mutations in the isocitrate dehydrogenase 1 and 2 ( IDH1 IDH2 ) genes are frequent molecular lesions acute myeloid leukaemia with normal karyotype (AML-NK). The effects of IDH mutations on clinical features treatment outcome AML-NK have been widely investigated, but only a few studies monitored these during follow-up. Patients methods In our study samples from 110 adult de novo were studied for presence mutations, their associations other prognostic markers disease...
Background: Cytarabine-anthracycline-based induction chemotherapy remains the standard of care for remission among patients with newly diagnosed acute myeloid leukaemia (AML). There are remarkable differences in therapy response AML patients. This fact could be partly explained by patients' genetic variability related to metabolic paths cytarabine and anthracyclines. study aims evaluate effect variants pharmacogenes SLC29A1, DCK, ABCB1, GSTM1, GSTT1, as well laboratory AML-related parameters...
There is a paucity of data on the effects enzyme replacement therapy (ERT) coagulation abnormalities and platelet function patients with Gaucher's disease (GDPs) much this are controversial. This study investigates haemostatic parameters in treatment-naïve GDPs ERT. 31 Serbian type 1 (M/F 17/14; median age 49 years, splenectomized 9/31) were studied. The complete blood count, prothrombin time (PT), activated partial tromboplastin (aPTT) factors measured using standard methods. Platelet...
Abstract Introduction Patients with acute promyelocytic leukemia (APL) are characterized by the highest expression of Wilms' tumor 1 ( WT1 ) gene compared other subtypes myeloid leukemia, and yet this molecular marker is almost never used for risk stratification in therapy response monitoring. Methods Quantitative assessment transcripts was performed using real‐time PCR method. The bone marrow samples were collected at time diagnosis 47 APL patients, 31/47 patients during follow‐up/relapse...
There are limited data on the impact of severe acute respiratory syndrome corona virus 2 infection in patients previously diagnosed with primary immune thrombocytopenia (ITP) thrombopoietin receptor agonist therapy (TPO-RA). Seven chronic ITP who had contracted COVID-19 and been treated TPO-RA included study. Demographic, treatment comorbidities were collected retrospectively from patients' medical records. Data regarding clinical course prospectively. During infection, all platelet count...
Patients with hematological malignancies have an increased risk of arterial thrombotic events (ATEs) after diagnosis, compared to matched controls without cancer. However, data about incidence and factors for ATE development in patients acute myeloid leukemia (AML) are missing.The objectives this study were determine the non-promyelocytic-AML define potential development.We conducted a retrospective cohort adult newly diagnosed AML. The primary outcome was occurrence confirmed ATE, defined...