A5064132032- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Blood Coagulation and Thrombosis Mechanisms
- Prenatal Screening and Diagnostics
- Cardiovascular Issues in Pregnancy
- Reproductive System and Pregnancy
- Venous Thromboembolism Diagnosis and Management
- Neonatal Respiratory Health Research
- Fetal and Pediatric Neurological Disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Congenital Anomalies and Fetal Surgery
- Congenital Diaphragmatic Hernia Studies
- Heavy Metal Exposure and Toxicity
- Congenital Heart Disease Studies
- Ovarian function and disorders
- Pregnancy and Medication Impact
- Urological Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- MicroRNA in disease regulation
- Parvovirus B19 Infection Studies
- Pancreatic function and diabetes
- Reproductive Biology and Fertility
- Paraoxonase enzyme and polymorphisms
- Systemic Lupus Erythematosus Research
University of Belgrade
2016-2025
Centar za Promociju Nauke
2012-2025
University of Belgrade – Faculty of Medicine
2023
Jena University Hospital
2018
Abstract Preeclampsia is a pregnancy-specific cardiovascular disorder, involving significant maternal endothelial dysfunction. Although inappropriate placentation due to aberrant angiogenesis, inflammation and shallow trophoblast invasion are the root causes of preeclampsia, pathogenic mechanisms poorly understood, particularly in early pregnancy. Here, we first confirm abnormal expression important vascular inflammatory proteins, FK506-binding protein-like (FKBPL) galectin-3 (Gal-3), human...
The objective of this study was to measure the different redox biomarker levels within follicular fluid (FF) and evaluate correlations with embryo quality using one follicle–one oocyte/embryo approach. prospective included 54 women (average age 34.6 ± 3.0 years). Out 235 mature metaphase II cells that underwent intracytoplasmic sperm injection, fertilization achieved in 177 cells, producing 92 Grade I embryos, 26 39 III 20 IV embryos. activities antioxidant enzymes, superoxide dismutase,...
Excessive gestational weight gain may be associated with unfavorable pregnancy outcomes. We explored the impact of excessive on components HDL metabolism in maternal plasma: sterol composition particles, distribution subclasses and SCARB1, ABCA1 ABCG1 genes expressions their associations newborns' characteristics. The study included 124 pregnant women, 58 recommended 66 gain. Concentrations cholesterol synthesis marker, desmosterol, within increased during both groups participants. In women...
Highlights • This study fills gap by exploring sphingolipid profile in late-onset preeclampsia Distinct sphingosine-1-phosphate (S1P) patterns were seen high-risk women without vs. group Preeclampsia had lower S1P 2nd, 3rd trimester, and before delivery High-density lipoprotein drop 2nd trimester group, aligning with concentrations Both cohorts showed rising sphingomyelin
Pregnancy complications increase the long-term cardiovascular risk for both mother and child. Inflammation is a common mechanism underlying development of pregnancy atherosclerosis. This study aims to investigate whether monocyte/HDL cholesterol ratio can serve as predictive marker complications. A total 84 pregnant women participated in this study, 41 whom had normal course, while 43 experienced Lipid status parameters were measured using enzymatic methods blood count was hematology...
Preeclampsia (PE) is a pregnancy complication marked by hypertension (≥ 140/90 mmHg) and proteinuria 300 mg/24 h), with an unclear pathogenesis involving inflammation dyslipidemia. This study aimed to longitudinally examine changes in lipid status parameters inflammatory markers pregnant women at high risk for PE those who developed PE. Among 91 women, 20 (PE group), 71 were high-risk (HR group). Both groups monitored four points: T1-first, T2-, T3-third trimester, T4-pre-delivery. Lipid...
Preeclampsia is a complex pregnancy disorder characterized by the new onset of hypertension and organ dysfunction, often leading to significant maternal fetal morbidity mortality. Placental dysfunction hallmark feature preeclampsia, which caused inappropriate trophoblast cell function in association with oxidative stress, inflammation and/or pathological hypoxia. This study explores role stress cell-based models mimicking preeclamptic placenta evaluates potential therapeutic strategies...
Abstract Preeclampsia is still the leading cause of morbidity and mortality in pregnancy without a cure. There are two phenotypes preeclampsia, early-onset (EOPE) late-onset (LOPE) with poorly defined pathogenic differences. This study aimed to facilitate better understanding mechanisms pathophysiology EOPE LOPE, identify specific biomarkers or therapeutic targets. In this study, we conducted an untargeted, label-free quantitative proteomic analyses plasma samples from pregnant women (n =...
With the ever-growing concern for human health and wellbeing, prenatal period of development requires special attention since fetuses can be exposed to various metals through mother. Therefore, this study explored status selected toxic (
Lymphangiomas are benign vascular malformations of the lymphatic system and most commonly present in neck area. Large lymphangiomas may compress and/or displace larynx, trachea esophagus cause serious respiratory feeding problems neonates. Prenatal therapy could eliminate risks mentioned complications. include EXIT (ex utero intrapartum treatment) procedure. As this procedure has certain for both neonate mother, introduction a safer method is justified. The use OK-432, as sclerosing agent,...
To investigate the frequency of torsion malignant ovarian tumors in children and adolescents.We evaluated all patients treated for adnexal a tertiary care referral pediatric institution during last 20 years. Presentation, tumor markers pathology reports were evaluated. We reviewed literature on tumors.Ninety-two girls (age 6 months to 19 years), 41 them premenarchal, surgically torsion. Symptoms signs that led clinical investigation subsequent surgery not specific. Histological findings...
<i>Backgound/Aims:</i> Existing data regarding the prevalence of thrombophilia in women with pregnancy complications are conflicting. <i>Methods:</i> To investigate relationship between pregnancy-associated and presence thrombophilia, we studied records 453 complications. In 55 women, intrauterine fetal death (fetus mortus utero, FMU) after 20 weeks gestation was recorded, 231 two or more consecutive recurrent losses (RFL) were while 167 had a venous thromboembolism...
Background. As a physiological condition closely linked with increased susceptibility to oxidative stress, pregnancy can be further compromised by cigarette smoking. Inadequate nutrition and reduced intake of antioxidants also disrupt the prooxidant/antioxidant relationship contribute stress. Increased stress during may involved in several complications pregnancy, such as preterm labor, fetal growth restriction, preeclampsia miscarriage.Objectives. The aim this study was investigate...
This study aims to explore potential variations in neonatal outcomes between pregnancies without complications and those complicated by preeclampsia within a tertiary gynecology obstetrics center Serbia. By focusing on outcomes, the research seeks provide nuanced understanding of how may impact health well-being newborns this specific medical setting. The investigation will shed light any distinctive patterns or disparities contributing valuable insights broader maternal context Serbian...
The aim of this study was to examine the effectiveness a combination parameters at first-trimester screening for fetal aneuploidies, including ultrasound assessment nasal bone (NB), blood flow in ductus venosus (DV) and across tricuspid valve.Screening aneuploidy carried out 4172 singleton pregnancies between January 2006 December 2010. Diagnostic accuracy combined [inclusive maternal age, nuchal translucency (NT) thickness serum free beta-human chorionic gonadotropin pregnancy-associated...