A5023017614- Pregnancy and preeclampsia studies
- Tryptophan and brain disorders
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Phytochemistry and Biological Activities
- Inflammatory Bowel Disease
- Stress Responses and Cortisol
- Gestational Diabetes Research and Management
- Phytochemical and Pharmacological Studies
- Signaling Pathways in Disease
- Pain Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Pharmaceutical Practices and Patient Outcomes
- Pharmacological Effects of Natural Compounds
- COVID-19 and Mental Health
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Analytical chemistry methods development
- Diabetes Treatment and Management
- Sleep and related disorders
- Diet and metabolism studies
- Olfactory and Sensory Function Studies
- Multiple Sclerosis Research Studies
- Cardiovascular Issues in Pregnancy
- Metabolomics and Mass Spectrometry Studies
Hashemite University
2020-2025
Arabian Gulf University
2023-2025
Jordan University of Science and Technology
2025
Queen's University Belfast
2017-2021
Epigallocatechin gallate (EGCG) is a catechin, which type of flavonoid found in high concentrations green tea. EGCG has been studied extensively for its potential health benefits, particularly cancer. to exhibit anti-proliferative, anti-angiogenic, and pro-apoptotic effects numerous cancer cell lines animal models. demonstrated the ability interrupt various signaling pathways associated with cellular proliferation division different types. anticancer activity mediated by interfering...
Abstract Preeclampsia is a pregnancy-specific cardiovascular disorder, involving significant maternal endothelial dysfunction. Although inappropriate placentation due to aberrant angiogenesis, inflammation and shallow trophoblast invasion are the root causes of preeclampsia, pathogenic mechanisms poorly understood, particularly in early pregnancy. Here, we first confirm abnormal expression important vascular inflammatory proteins, FK506-binding protein-like (FKBPL) galectin-3 (Gal-3), human...
Background: Isorhamnetin is a flavonoid that found in medical plants. Several studies showed isorhamnetin has anti-inflammatory and anti-obesity effects. This study aims to investigate the anti-diabetic effects of high-fat diet Streptozotocin-(HFD/STZ)-induced mice model type 2 diabetes. Materials Methods: Mice were fed with HFD followed by two consecutive low doses STZ (40 mg/kg). HFD/STZ diabetic treated orally (10 mg/kg) or (200 metformin for 10 days before sacrificing collecting plasma...
The flavonoid compound Isorhamnetin (IRMN) is known for its considerable pharmacological properties, which include antioxidant and anti-inflammatory effects, as well significant protective actions on heart health. However, the potential of IRMN to guard against damage caused by cisplatin (CP), a common chemotherapeutic agent, specific mechanisms involved, remain unexplored areas. This research was designed investigate how counters CP-induced toxicity. In our study, mice were orally given at...
Optimising breast cancer treatment remains a challenge. Resistance to therapy is major problem in both ER- and ER+ cancer. Tumour recurrence after chemotherapy and/or targeted leads more aggressive tumours with enhanced metastatic ability. Self-renewing stem cells (CSCs) have been implicated resistance, the development of disease. In this study, we utilised vitro, vivo ex models using MCF-7 MDA-MB-231 cells, as well solid patient samples, interrogate effects FKBPL its peptide therapeutics on...
The Jordanian and the Palestinian communities are tightly related, hence, current war on Gaza also has social psychological impacts Jordanians. Therefore, this study aims to identify factors associated with severe insomnia fatigue symptoms in a cohort of Jordanians during War outbreak. This is cross-sectional web-based questionnaire study. Insomnia Severity Index-Arabic version (ISI-A), Brief Fatigue Inventory-Arabic (BFI-A) were employed, binary logistic linear regression analyses was...
Abstract Context Preeclampsia is a leading cardiovascular complication in pregnancy lacking effective diagnostic and treatment strategies. Objective To investigate the therapeutic target potential of angiogenesis proteins, FK506-binding protein like (FKBPL) CD44. Design Intervention FKBPL CD44 plasma concentration or placental expression were determined women pre- postdiagnosis preeclampsia. Trophoblast endothelial cell function was assessed following mesenchymal stem (MSC) context...
The perturbation in plasma free amino acid metabolome has been observed previously diabetes mellitus, and is associated with insulin resistance as well the onset of cardiovascular disease this population. In study, we investigated, for first time, changes profile a group people without type 2 (T2D) normal BMI, from Jordan, who were only managed on metformin. Twenty one acids evaluated samples 124 T2D 67 healthy controls, matched age, gender using analyser. Total acids, essential...
Diabetes in pregnancy is associated with adverse outcomes including preterm birth. Although the mechanisms leading to these complications are still poorly understood, aberrant angiogenesis and endothelial dysfunction play a key role. FKBPL SIRT-1 critical regulators of angiogenesis, however, their roles pregnancies affected by diabetes have not been examined before detail. Hence, this study aimed investigate role pre-gestational (type 1 mellitus, T1D) gestational mellitus (GDM). Placental...
Ceratonia siliqua L. (Leguminosae) has neuroprotective, mutagenic, hypotensive, anti-bacterial, hypoglycaemic, and anti-inflammatory effects through extracts from its leaves. Therefore, the aim of this study is to assess anti-nociceptive activity ethanol leaves.Ethanol extract leaves were studied using well-established animal models inflammation pain. A hot plate latency assay (55 °C) was used analgesic effect 10, 31.6, 100, 316 mg/kg doses in addition paw licking time early late phase a...
Background/Objectives: The current study aims to investigate the rate and factors associated with mobile screen dependence as a coping mechanism among women residing in Jordan screened for stress, focus on demographics insomnia. Methods: This cross-sectional predefined inclusion criteria used validated tools assess anxiety, Results: data analyzed from 431 showed that 265 (61.5%) were ≤25 years old, 352 (81.7%) received university education, 201 (46.6%) students. In addition, 207 (48.0%)...
To evaluate the analgesic and neuroprotective effects of cytidine, uridine, gabapentin-administered alone in combination-in models diabetic neuropathy formalin-induced acute inflammatory pain. Oral doses gabapentin (100 mg/kg each) were administered to rats with streptozotocin-induced a formalin test model. Behavioral responses recorded at 30, 60, 120 minutes following treatment after five weeks diabetes induction. Spinal cord p-CREB expression was measured assess molecular changes,...
Abstract Depression is linked with oxidative stress and inflammation, where key players include nitric oxide (NO), nuclear factor erythroid 2-related 2 (Nrf2), Brain-Derived Neurotrophic Factor (BDNF), Heme Oxidase-1 (HO-1). Augmenting the efficacy of antidepressants represents a compelling avenue exploration. We explored potential vitamins C D as adjuncts to escitalopram (Esc) in lipopolysaccharide (LPS)-induced depression model focusing on aforementioned biomarkers. Male Swiss albino mice...
Aim : The study aims to investigate the association between type 2 diabetes and adipokines, particularly resistin adiponectin, in insulin resistance. It also explores potential of adiponectin ratio as an indicator for these conditions Methods This research involved 198 participants, including 100 patients with 98 controls. focused on measuring various biochemical parameters like HbA1c, fasting plasma glucose, lipid profiles (low-density lipoprotein, oxidized low-density triglyceride, total...
Context Type 2 Diabetes Mellitus (T2D) is a significant health concern worldwide, necessitating novel therapeutic approaches beyond conventional treatments.