Meton Soares de Alencar Filho
A5002865070- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Nosocomial Infections in ICU
- Antibiotic Use and Resistance
- Family and Patient Care in Intensive Care Units
- Cardiac Arrest and Resuscitation
- Neonatal Respiratory Health Research
- Sepsis Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- Virus-based gene therapy research
- Cancer Genomics and Diagnostics
Hospital São Vicente de Paulo
2017-2025
Hospital São Vicente
2024
The effects of recruitment maneuvers and positive end-expiratory pressure (PEEP) titration on clinical outcomes in patients with acute respiratory distress syndrome (ARDS) remain uncertain.To determine if lung associated PEEP according to the best respiratory-system compliance decreases 28-day mortality moderate severe ARDS compared a conventional low-PEEP strategy.Multicenter, randomized trial conducted at 120 intensive care units (ICUs) from 9 countries November 17, 2011, through April 25,...
Limited data is available to evaluate the burden of device associated healthcare infections (HAI) [central line bloodstream infection (CLABSI), catheter urinary tract (CAUTI), and ventilator pneumonia (VAP)] in low and-middle-income countries. Our aim investigate population attributable mortality fraction absolute difference HAI a broad critically ill patients from Brazil. Multicenter cohort study September 2019 December 2023 with prospective individual patient collection. VAP, CLABSI, CAUTI...
Driving pressure has been suggested to be the main driver of ventilator-induced lung injury and mortality in observational studies acute respiratory distress syndrome. Whether a driving pressure-limiting strategy can improve clinical outcomes is unclear.
The detection of genetic alterations in patients with acute leukemias is essential for the targeting more specific and effective therapies. Therefore, aim this study was to compare sensitivity Nested-PCR RT-qPCR techniques leukemias. This included samples from 117 treated at Fortaleza General Hospital. All were submitted analysis using techniques. Acute Myeloid Leukemia (AML) patients’ following alterations: FLT3-ITD, RUNX1::RUNX1T1, CBFB::MYH11 PML::RARA; meanwhile, BCR::ABL1, TCF3::PBX1,...
To compare the lung mechanics and outcomes between COVID-19-associated acute respiratory distress syndrome non-COVID-19-associated syndrome.We combined data from two randomized trials in syndrome, one including only COVID-19 patients other without COVID-19, to determine whether is associated with higher 28-day mortality than non-COVID-19 examine differences these types of syndrome.A total 299 1,010 were included main analysis. The results showed that used positive end-expiratory pressure...
Abstract Background Nosocomial sepsis is a major healthcare issue, but there are few data on estimates of its attributable mortality. We aimed to estimate mortality fraction (AF) due nosocomial sepsis. Methods Matched 1:1 case–control study in 37 hospitals Brazil. Hospitalized patients participating were included. Cases hospital non-survivors and controls survivors, which matched by admission type date discharge. Exposure was defined as occurrence sepsis, antibiotic prescription plus...
RESUMO Contexto: Em estudos observacionais sobre a síndrome do desconforto respiratório agudo, sugeriu-se que driving pressure é o principal fator de lesão pulmonar induzida por ventilador e mortalidade. Não está claro se uma estratégia limitação da pode melhorar os desfechos clínicos. Objetivo: Descrever protocolo plano análise estatística serão usados para testar envolvendo titulação pressão positiva expiratória final acordo com melhor complacência respiratória redução volume corrente...
OBJECTIVE: To compare the lung mechanics and outcomes between COVID-19-associated acute respiratory distress syndrome non-COVID-19-associated syndrome. METHODS: We combined data from two randomized trials in syndrome, one including only COVID-19 patients other without COVID-19, to determine whether is associated with higher 28-day mortality than non-COVID-19 examine differences these types of RESULTS: A total 299 1,010 were included main analysis. The results showed that used positive...
Repurposed drugs are important in resource-limited settings because the interventions more rapidly available, have already been tested safely other populations and inexpensive. an effective solution, especially for emerging diseases such as COVID-19. The REVOLUTIOn trial has objective of evaluating three repurposed antiviral drugs, atazanavir, daclatasvir sofosbuvir, used HIV- hepatitis C virus-infected patients a randomized, placebo-controlled, adaptive, multiarm, multistage study. will be...
Repurposed drugs are important in resource-limited settings because the interventions more rapidly available, have already been tested safely other populations and inexpensive.Repurposed an effective solution, especially for emerging diseases such as COVID-19.The REVOLUTIOn trial has objective of evaluating three repurposed antiviral drugs, atazanavir, daclatasvir sofosbuvir, used HIV-and hepatitis C virus-infected patients a randomized, placebo-controlled, adaptive, multiarm, multistage...