A5011923349- Amyloidosis: Diagnosis, Treatment, Outcomes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Peptidase Inhibition and Analysis
- Chronic Myeloid Leukemia Treatments
- Antioxidant Activity and Oxidative Stress
- Acute Myeloid Leukemia Research
- Cell Adhesion Molecules Research
- Innovative Approaches in Technology and Social Development
- Trace Elements in Health
- Lipid Membrane Structure and Behavior
- Infection Control in Healthcare
- Infection Control and Ventilation
- Cardiac, Anesthesia and Surgical Outcomes
- Fatty Acid Research and Health
- Sphingolipid Metabolism and Signaling
- Immune Cell Function and Interaction
- Electrospun Nanofibers in Biomedical Applications
- Lipid metabolism and biosynthesis
- Protein Kinase Regulation and GTPase Signaling
- Delphi Technique in Research
- Tissue Engineering and Regenerative Medicine
- Glutathione Transferases and Polymorphisms
- Mobile Health and mHealth Applications
- Skin and Cellular Biology Research
- Nosocomial Infections in ICU
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2023-2024
Centro Tecnológico das Indústrias Têxtil e do Vestuário de Portugal
2024
Hospital São Paulo
2022
Universidade Federal de São Paulo
2022
University of Aveiro
2017
Universidade do Porto
2004-2012
Instituto de Biologia Molecular e Celular
2007-2012
Institut de Biologie Moléculaire et Cellulaire
2012
Institute for Biotechnology and Bioengineering
2010
Rede de Química e Tecnologia
2001
Alterations of phospholipid (PL) profiles have been associated to disease and specific lipids may be involved in the onset evolution cancer; yet, analysis PL using mass spectrometry (MS) breast cancer cells is a novel approach. Previously, we reported lipidomic PLs from mouse mammary epithelial off-line thin layer chromatography (TLC)-MS, where several changes profile were found with degree malignancy cells. In present study, has extended human cell lines (MCF10A, T47-D, MDA-MB-231), TLC-MS,...
In familial amyloidotic polyneuropathy, TTR (transthyretin) variants are deposited as amyloid fibrils. It is thought that this process involves tetramer dissociation, which leads to partially unfolded monomers aggregate and polymerize into This can be counteracted by stabilization of the tetramer. Several small compounds, such diclofenac, diflunisal flufenamic acid, have been reported bind in vitro, T4 (thyroxine) binding channel runs through tetramer, consequently considered stabilize TTR....
The identification of specific biomarkers provides opportunities to develop early diagnostic parameters, monitor disease progression, and test drug efficiency in clinical trials. We previously demonstrated that familial amyloidotic polyneuropathy (FAP) related the abnormal extracellular tissue deposition mutant transthyretin (TTR), inflammatory apoptotic pathways are triggered presymptomatic stages disease, when nonfibrillar TTR deposits present. In present work, better define for future...
Abstract Background Nosocomial sepsis is a major healthcare issue, but there are few data on estimates of its attributable mortality. We aimed to estimate mortality fraction (AF) due nosocomial sepsis. Methods Matched 1:1 case–control study in 37 hospitals Brazil. Hospitalized patients participating were included. Cases hospital non-survivors and controls survivors, which matched by admission type date discharge. Exposure was defined as occurrence sepsis, antibiotic prescription plus...
Living Labs, experiencing a global surge in popularity over the past years, demands standardized guidance through development of widely accepted good practices. While challenging due to complex and evolving nature this task remains essential. These knowledge innovation ecosystems facilitate diverse array interconnected interacting end-users stakeholder partners who engage collaboratively co-create, embed, and/or leverage end-user-centric breakthroughs at one or more phases within real-world...
Este artigo revisa a literatura atual sobre eficácia das terapias intraoperatórias no controle de metástases em cirurgias oncológicas. A seleção dos artigos foi realizada utilizando base dados PubMed e os termos “Oncologic Surgery”, “Intraoperative Therapies”, “Metastasis Control”. revisão abrange estudos recentes que investigam intervenções intraoperatórias, como radioterapia intraoperatória (IORT), ablação térmica lavagem peritoneal extensiva, com foco na sua reduzir recidiva melhorar...
Este estudo explora o potencial terapêutico das células-tronco na regeneração miocárdica após infarto agudo do miocárdio, com ênfase nos desfechos clínicos e funcionais observados em pacientes afetados. A terapia células-tronco, especial as derivadas da medula óssea cardíacas, emerge como uma alternativa promissora recuperação tecido cardíaco danificado. No entanto, a variabilidade resultados falta de uniformidade protocolos terapêuticos revelam necessidade estudos adicionais que aprofundem...
The paediatric oncology field still faces significant challenges, despite the substantial progress in childhood cancer diagnosis and treatment. Not only terms of incidence mortality rate reduction but also patients, their support system (e.g. family, school staff) survivors’ well-being. use innovation has provided new forms to community. As these solutions continue emerge it is necessary test validate them based on end-users’ specific needs. In this context, article shares ongoing work...
Aim: The aim of the study is to evaluate expression aldehyde dehydrogenase (ALDH) in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) verify their potential as a marker for diagnosis and/or prognosis these diseases. Introduction: ALDH superfamily group 19 enzymes critical protection against toxic aldehydes, have been associated multiple diseases, namely cancer. MDS are characterized by ineffective hematopoiesis progressive peripheral blood cytopenias,...