A5078622719- Renal Diseases and Glomerulopathies
- Systemic Lupus Erythematosus Research
- Chronic Kidney Disease and Diabetes
- Vasculitis and related conditions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Biomedical Research and Pathophysiology
- Complement system in diseases
- Liver Diseases and Immunity
- Public Health in Brazil
- Renal and Vascular Pathologies
- Blood groups and transfusion
- Autoimmune Bullous Skin Diseases
- Systemic Sclerosis and Related Diseases
- Blood Pressure and Hypertension Studies
- Diabetes and associated disorders
- Dialysis and Renal Disease Management
- Platelet Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Male Reproductive Health Studies
- Parathyroid Disorders and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Birth, Development, and Health
- Celiac Disease Research and Management
- Reproductive System and Pregnancy
- Skin Diseases and Diabetes
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2006-2025
Universidade de São Paulo
2013-2024
Universidade Brasil
2011-2022
Pediatric Nephrology of Alabama
2017
Fundação Faculdade de Medicina
2015
Universidade do Vale do Sapucaí
2012
Associação Fundo de Incentivo à Pesquisa
2010
Universidade Federal de São Paulo
2006
Faculdade de Ciências Médicas da Santa Casa de São Paulo
2006
Universidade do Oeste Paulista
2006
Background. The Paulista Registry of Glomerulopathies was created in May 1999 and comprises several centres São Paulo, the most populous Brazilian State, that concentrates people from all regions country who look for health care. Methods. This report includes data 2086 patients Brazil submitted to renal biopsy due presumed diagnosis glomerular diseases, registered prospectively since until January 2005. Data were collected by integrants 11 involved, utilizing a standardized questionnaire....
Objective: To evaluate clinicopathological features and treatment response in patients with lupus nephritis (LN), comparing the childhood- late-onset forms of disease. Methods: We retrospectively analyzed clinical presentation, evolution diagnosed LN by renal biopsy between 1999 2008. Patients were grouped age—≤18 years ( n = 23); ≥50 13)—and followed for first year treatment. Results: The baseline groups, respectively, as follows: mean age, 15 ± 2 54 5 years; female gender, 87% 92%;...
Introduction: Focal segmental glomerulosclerosis (FSGS) is a pattern of kidney injury with diverse causes and pathogeneses, resulting in podocyte depletion. It can be classified as primary, genetic, or secondary. Because FSGS classically has worse prognosis patients nephrotic syndrome, most studies have focused on the treatment evolution these patients, lack data related to without syndrome. The objective this study was establish main etiologies, characteristics, renal disease non-nephrotic...
Acute renal failure (ARF) has been frequently reported after bites from the Viperidae snake family. The lack of a reproducible animal model hampered study damage mechanisms. Intravenous injection rats with 0.4 mg/kg Bothrops jararaca venom produced functional and morphologic changes similar to those observed in human snakebite-induced ARF. There was an acute significant decrease glomerular filtration rate, diuresis, plasma flow. Serum fibrinogen levels decreased significantly. intravascular...
ABSTRACT Objective An imbalance between angiogenic and antiangiogenic factors has been implicated in the pathogenesis severity of preeclampsia. In this study, we evaluated serum levels an factor – placental growth (PlGF) soluble fms‐like tyrosine kinase 1 (sFlt‐1), respectively pregnant women with preeclampsia, as well evaluating impact those on maternal fetal outcomes. Method We studied 44 diagnosed preeclampsia admitted to intensive care unit (ICU). The was classified (by weeks gestation...
Progression and long-term renal outcome of lupus nephritis (LN) in male patients is a controversial subject the literature. The aim this study was to evaluate influence gender on LN.All (M) LN who fulfilled American College Rheumatology criteria were referred for kidney biopsy from 1999 2009 enrolled study. Subjects with end-stage disease at baseline, or follow-up time below 6 months, excluded. Cases randomly matched female (F) according class LN, baseline estimated glomerular filtration...
MYH9 polymorphisms have been described to be associated with the risk of CKD in non-diabetic nephropathy, HIV nephropathy and FSGS. Predominating black descendants, MHY9 genetic variants could partially explain excess African ancestry. However, recent data suggests that APOL1 gene co-segregate MYH9, truly risk. In this study, we evaluated role Brazilian patients lupus nephritis (LN). A retrospective analysis 196 LN was done. rs4821480, rs2032487, rs4821481 rs3752462, APOL 1rs73885319,...
Aims: Thioredoxin interacting protein (TXNIP), an inhibitor of antioxidant thioredoxin (Trx), is upregulated by hyperglycemia and implicated in pathogenesis diabetes complications. We evaluated mRNA expressions genes encoding TXNIP Trx (TXN) urinary sediment peripheral blood mononuclear cells (PBMC) type 1 (T1D) patients with different degrees chronic Methods: qPCR was employed to quantify target (n = 55) PBMC 161) from sorted presence or absence diabetic nephropathy (DN), retinopathy,...
IgA nephropathy (IgAN) is the most common primary glomerulopathy worldwide. According to Oxford Classification, changes in kidney vascular compartment are not related with worse outcomes. This paper aims assess impact of thrombotic microangiopathy (TMA) outcomes Brazilian patients IgAN.Analysis clinical data and biopsy findings from IgAN TMA on renal outcomes.The majority 118 included were females (54.3%); mean age 33 years (25;43); hypertension hematuria observed 67.8% 89.8%, respectively....
Objective. To evaluate whether the A/G polymorphism at position −2518 in regulatory region of monocyte chemoattractant protein-1 (MCP-1) or V/I −64 receptor, CCR2, are associated with lupus nephritis (LN) any clinical characteristics disease renal survival a patient population. Methods. We selected 197 patients and 220 matched healthy controls for study. MCP-1 CCR2 genotyping was performed by polymerase chain reaction. Clinical laboratory data were compiled from patients’ charts over...
Focal segmental glomerulosclerosis (FSGS) is the most prevalent primary glomerulopathy in Brazil and its incidence increasing worldwide. Pathogenesis related to podocyte injury, which may be due several factors including viruses, drugs, immunology. In 2004, Columbia classification of FSGS identified five histologic variants disease: collapsing (COL), usual (not otherwise specified, NOS), tip lesion (TIP), perihilar (PHI) cellular variant (CEL). Several studies have demonstrated molecular...
Fc gamma RIIa is a low affinity receptor that has two co-dominantly expressed alleles, R131 and H131, which differ in their ability to bind immunoglobulin G (IgG) subclasses. Cells expressing H131 more efficiently complexed IgG2 IgG3 than those the variant. The polymorphism been shown be associated with lupus nephritis. Here we evaluated relevance of gene development immune complex (IC)-mediated nephritis by comparing genotype allelic distribution this ethnically matched healthy controls...
Introduction: Urinary CD80 has been shown to have good specificity for minimal change disease (MCD) in children. However, the investigation of circulating factors such as soluble urokinase plasminogen activator receptor (suPAR) biomarkers focal segmental glomerulosclerosis (FSGS) is quite controversial. The objective this study was determine whether urinary and serum suPAR can be used diagnosis MCD FSGS, respectively, adult population Brazil. We also attempted those assess response...
In Brazil, schistosomiasis is caused only by Schistosoma mansoni, occurring in the northeastern and southeastern regions. Schistosomiasis primarily affects liver gastrointestinal tract, although kidneys can also be affected, mainly form of glomerulopathies. Here, we describe characteristics patients with schistosomiasis-associated glomerulopathies, including treatment renal outcomes.This was a retrospective analysis diagnosed glomerulopathy between 2002 2017. Clinical, biochemical,...
In the present study we examined whether chronic intracerebroventricular (ICV) leptin administration protects against ischemia/reperfusion (I/R)-induced acute kidney injury (AKI). Twelve-week-old male rats were implanted with an ICV cannula into right lateral ventricle and 8-10 days after surgery, (0.021 mg/hr, n=8) or saline vehicle (0.5 ml/h, was infused via osmotic minipump connected to for 12 days. On day 8 of infusion, submitted unilateral (UIR) by clamping left pedicle 30 min. To...
Glomerular crescents were analyzed as a prognostic factor in retrospectively reviewed data from 144 patients with biopsy-proven IgA nephropathy. Crescents found 26 (18%) patients, and detected 2 to 100% of glomeruli each specimen. In 5% the more than 50% affected. Thirty nephropathy without studied control group. Mean age was 30.3 ± 9.4 30.2 12.0 years for crescents, respectively, males prevailed both groups. The length follow-up 23.2 41.6 months 29.3 35.3 crescents. Eighty percent...
Collapsing glomerulopathy (CG) is a severe form of nephrotic syndrome and has been mostly associated with human immunodeficiency virus (HIV) infection. Treatment response poor, the disease frequently leads to end-stage renal disease. More recently, CG described in association other conditions, such as drug exposure infections, but prognosis remains unfavorable. This paper reports an interesting case HIV-negative patient tuberculosis-related who needed dialysis for five months presented full...