A5064339436- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Systemic Lupus Erythematosus Research
- Pregnancy and preeclampsia studies
- Public Health in Brazil
- Renal Transplantation Outcomes and Treatments
- Renal and Vascular Pathologies
- Vasculitis and related conditions
- Pregnancy and Medication Impact
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Lysosomal Storage Disorders Research
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Biomedical Research and Pathophysiology
- Autoimmune Bullous Skin Diseases
- Muscle and Compartmental Disorders
- Healthcare Systems and Reforms
- Acute Kidney Injury Research
- Blood Pressure and Hypertension Studies
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- Glycogen Storage Diseases and Myoclonus
- Healthcare cost, quality, practices
- Muscle metabolism and nutrition
Universidade Federal de São Paulo
2016-2025
Universidade Federal do Rio de Janeiro
2024
Sociedade de Nefrologia do Estado de São Paulo
2012-2024
Hospital São Paulo
2023
Sociedad Española de Nefrología
2021
Sociedad Española de Reumatología
2021
Mettler-Toledo (United Kingdom)
2021
Maestro (Sweden)
2021
Hospital do Rim e Hipertensão
2011-2020
Union des Industries Ferroviaires Européennes
2011-2020
For addressing the influence of muscle mass on serum and urinary creatinine cystatin C, body composition was assessed by skinfold thickness measurement bioelectrical impedance analyses.A total 170 healthy individuals (92 women, 78 men) were classified as sedentary or with mild moderate/intense physical activity. Blood, 24-h urine samples, food recall obtained from all individuals.Serum correlated significantly weight, but level correlation lean even greater. There no significant between...
Background and objectives FSGS recurrence after kidney transplantation is a major risk factor for graft loss. However, the natural history, clinical predictors, response to treatment remain unclear because of small sample sizes poor generalizability single-center studies, disease misclassification in registry-based studies. We therefore aimed determine incidence, recurrent large cohort transplant recipients. Design, setting, participants, & measurements The Post-Transplant Glomerular...
An unmet need exists for focal segmental glomerulosclerosis (FSGS) treatment. In an 8-week, phase 2 trial, sparsentan, a dual endothelin–angiotensin receptor antagonist, reduced proteinuria in patients with FSGS. The efficacy and safety of longer-term treatment sparsentan FSGS are unknown. Download PDF the Research Summary. this 3 we enrolled (without known secondary causes) who were 8 to 75 years age; randomly assigned receive or irbesartan (active control) 108 weeks. surrogate end point...
Abstract Introduction: Glomerular diseases can be associated with solid or hematopoietic malignancies. The prevalence of these associations varies according to the studied glomerular disease. This study aimed evaluate frequency and type neoplasms in patients as well their clinical, laboratory, histopathological features relationship immunosuppressive therapy. Methods: was a retrospective, descriptive, observational, longitudinal that reviewed 4,820 medical records included 95 disease...
At present, chronic kidney disease (CKD) is broadly defined on the basis of changes in glomerular filtration rate and/or presence parenchymal damage present for at least 3 months. Although diagnosis CKD now quite straightforward, proportion patients with end-stage renal seen by a nephrologist first time immediately before initiation dialysis still unacceptable. Early and immediate nephrology referral are key steps management because enable predialysis education, allow implementation...
Background. Studies about the prevalence of renal and particularly glomerular diseases in Brazil are still scarce. Methods. We evaluated retrospectively reports 9,617 biopsies, analyzed by same pathologist, from January 1993 to December 2007. Results. The biopsies performed subjects all ages native kidneys. 4,619 were primary glomerulopathies (GN), most frequent was focal segmental glomerulosclerosis (FSGS, 24.6%), followed membranous nephropathy (MN, 20.7%), IgA (IgAN, 20.1%), minimal...
Background and objectives In patients with kidney failure due to IgA nephropathy, deposits can recur in a subsequent transplant. The incidence, effect, risk factors of nephropathy recurrence is unclear, because most studies have been single center sample sizes are relatively small. Design, setting, participants, & measurements We performed multicenter, international, retrospective study determine the factors, treatment response recurrent after transplantation. Data were collected from...
Abstract Collapsing glomerulopathy (CG) has a severe course typically associated with viral infections, especially HIV and parvovirus B19, systemic lupus erythematosus (SLE), among other etiologies. A 35-year-old woman recent use of JAK inhibitor due to rheumatoid arthritis presented 2-week history fever, cervical adenopathy, facial erythema. After admission, anemia, hypoalbuminemia, proteinuria, acute kidney injury were noted. SLE was diagnosed B19 DNA detected in serum samples. Kidney...
Background. The Paulista Registry of Glomerulopathies was created in May 1999 and comprises several centres São Paulo, the most populous Brazilian State, that concentrates people from all regions country who look for health care. Methods. This report includes data 2086 patients Brazil submitted to renal biopsy due presumed diagnosis glomerular diseases, registered prospectively since until January 2005. Data were collected by integrants 11 involved, utilizing a standardized questionnaire....
Abstract Background Equations to estimate GFR have not been well validated in the elderly and may misclassify persons with chronic kidney disease (CKD). We measured compared performance of Modification Diet Renal Disease (MDRD), Chronic Kidney Disease-Epidemiology Collaboration (CKD-Epi) Berlin Initiative Study (BIS) equations based on creatinine and/or cystatin C octogenarians nonagenarians. Methods Using cross-sectional analysis we assessed 95 very (mean 85 years) living community. was by...
ABSTRACT Introduction: The prevalence of chronic kidney disease (CKD) is increasing worldwide, with costs that can be impeditive. Objective: To establish the expenses Brazilian Public Healthcare System (SUS), hospitalizations due to CKD and related diseases; evaluating renal replacement therapy (RRT). Methods: We have assessed values paid by SUS in triennium 2013-2015, for estimating annual treatment hospitalization, associated diseases, exams. Results: There was an increase hospitalization...
<b><i>Background:</i></b> Estimated glomerular filtration rate (eGFR) is very important in clinical practice, although it not adequately tested different populations. We aimed at establishing the best eGFR formulas for a Brazilian population with emphasis on need race correction. <b><i>Methods:</i></b> evaluated 202 individuals chronic kidney disease (CKD) and 42 without previously known renal lesions that were additionally screened by...
Resumo A glomerulopatia colapsante (GC) apresenta um curso grave, tipicamente associado a infecções virais, especialmente HIV e parvovírus B19, lúpus eritematoso sistêmico (LES), entre outras etiologias. Uma mulher de 35 anos, com uso recente inibidor JAK devido à artrite reumatoide, apresentou histórico duas semanas febre, adenopatia cervical eritema facial. Após admissão, observou-se anemia, hipoalbuminemia, proteinúria injúria renal aguda grave. Foi diagnosticado LES o DNA do B19 foi...
Resumo Introdução: Doenças glomerulares podem estar associadas a malignidades sólidas ou hematopoiéticas. A prevalência dessas associações varia conforme doença glomerular estudada. O objetivo deste estudo foi avaliar frequência e tipo de neoplasias em pacientes com doenças glomerulares, bem como suas características clínicas, laboratoriais histopatológicas relação terapia imunossupressora. Métodos: Estudo retrospectivo, descritivo, observacional longitudinal que analisou 4.820 prontuários...
Exertional rhabdomyolysis (ER) is one of the severe complications attributable to prolonged and repeated muscle exercises most commonly seen in military personnel elite athletes. In personnel, ER usually results from long strenuous nature training may sometimes result outcomes, such as acute kidney injury (AKI) cardiac arrhythmias. Besides, tissue injuries impair physical function, decreasing strength flexibility delaying soreness inflammation. The existing literature has studied genetic...
Membranous nephropathy (MN) is a leading cause of kidney failure worldwide, and frequently recurs after transplant. Available data originated from small retrospective cohort studies or registry analyses. Therefore, uncertainties remain on risk factors for MN recurrence response to therapy. Within the Post-Transplant Glomerular Disease (TANGO) Consortium, we conducted multicenter study examining rate, factors, treatment. This screened 22,921 patients across three continents included 194 who...
Abstract Background Although approximately 25% of Brazilians have private health coverage (PHC), studies on the surveillance chronic kidney disease (CKD) in this population are scarce. The objective study was to estimate prevalence CKD individuals under two PHC regimes Brazil, who total 8,335,724 beneficiaries. Methods Outpatient serum creatinine and proteinuria results from all five regions ≥ 18 years age, performed between 10/01/2021 10/31/2022, were analyzed through own laboratory network...
We carried out a prospective randomized trial comparing pulse cyclophosphamide and methylprednisolone in 29 patients with severe lupus nephritis activity. Patients were assigned to one of two regimens: monthly (0.5-1.0 g/m 2 body surface area) for 4 months, followed by bimonthly doses months quarterly 6 (14 patients) or (10-20 mg/kg weight) initially 3 consecutive days thereafter the same intervals as alternative regimen (15 patients). The mean follow-up was 15 months. Two group three died....
The objective of this study was to evaluate the frequency CD4+ T cell subsets in peripheral blood mononuclear cells (PBMC), urine and renal tissue from patients with lupus nephritis (LN). PBMC urinary were collected 17 active LN, 20 disease controls (DC) primary glomerulonephritis 10 healthy (HC) analysed by flow cytometry markers for helper type 1 (Th1), Th2, Th17 regulatory (Treg ) cells. assessed immunohistochemistry LN biopsy specimens 12 patients. subtypes re-evaluated at 6 months...