A5088993986- Acute Kidney Injury Research
- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Muscle and Compartmental Disorders
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Renal and Vascular Pathologies
- Bone and Joint Diseases
- Chemotherapy-induced organ toxicity mitigation
- Renal function and acid-base balance
- Liver Disease and Transplantation
- Cytomegalovirus and herpesvirus research
- Liver Disease Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Neurological Complications and Syndromes
- Cell death mechanisms and regulation
- Blood donation and transfusion practices
- Cardiac Ischemia and Reperfusion
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Bone health and treatments
- Listeria monocytogenes in Food Safety
Universidade Federal de São Paulo
2012-2025
Hospital Israelita Albert Einstein
2013-2024
Hospital São Paulo
2010-2022
Union des Industries Ferroviaires Européennes
2019
Hospital do Rim e Hipertensão
2010
Abstract Collapsing glomerulopathy (CG) has a severe course typically associated with viral infections, especially HIV and parvovirus B19, systemic lupus erythematosus (SLE), among other etiologies. A 35-year-old woman recent use of JAK inhibitor due to rheumatoid arthritis presented 2-week history fever, cervical adenopathy, facial erythema. After admission, anemia, hypoalbuminemia, proteinuria, acute kidney injury were noted. SLE was diagnosed B19 DNA detected in serum samples. Kidney...
<b><i>Background:</i></b> Critically ill patients with COVID-19 may develop multiple organ dysfunction syndrome, including acute kidney injury (AKI). We report the incidence, risk factors, associations, and outcomes of AKI renal replacement therapy (RRT) in critically patients. <b><i>Methods:</i></b> performed a retrospective cohort study adult diagnosis admitted to intensive care unit (ICU) between March 2020 May 2020. Multivariable logistic...
Resumo A glomerulopatia colapsante (GC) apresenta um curso grave, tipicamente associado a infecções virais, especialmente HIV e parvovírus B19, lúpus eritematoso sistêmico (LES), entre outras etiologias. Uma mulher de 35 anos, com uso recente inibidor JAK devido à artrite reumatoide, apresentou histórico duas semanas febre, adenopatia cervical eritema facial. Após admissão, observou-se anemia, hipoalbuminemia, proteinúria injúria renal aguda grave. Foi diagnosticado LES o DNA do B19 foi...
Background/aims: Necrostatin-1 (Nec-1) inhibits necroptosis, a nonapoptotic cell death pathway. Acute kidney injury (AKI) is clinical problem of high incidence and mortality. It involves several mechanisms death. We aim to evaluate the effect Nec-1 in toxic model by cisplatin. Methods: analyzed AKI cisplatin human proximal tubule cells flow cytometry. Results: Our results show that has no on apoptosis renal tubular epithelial (Nec-1 + Cis group 13.4 ± 1.7% vs. 14.6 1.4%) (p > 0.05). But,...
Introduction Multicenter studies involving patients with acute kidney injury (AKI) associated the disease caused by new coronavirus (COVID-19) and treated renal replacement therapy (RRT) in developing countries are scarce. The objectives of this study were to evaluate demographic profile, clinical picture, risk factors for mortality, outcomes critically ill AKI requiring dialysis (AKI-RRT) COVID-19 megalopolis São Paulo, Brazil. Methods This multicenter, retrospective, observational was...
The incidence and outcomes of acute kidney injury (AKI) in transplantation are poorly known. Retrospective cohort analysis was performed on the data all patients (≥3 months after ≥16 years age) admitted to hospital due medical or surgical complications from 2007 2010. We analyzed 458 transplant recipients, 55.2% men, median age 49 (IQR, 36-58) years, 12.5 3-35) transplantation; complications. Most received a deceased donor (62.2%), primary cause for admission infection (60.7%) 57 (12.4%)...
The objective of this study was to show the morphologic characteristics allograft renal biopsies in transplant patients with stable function, which can potentially be early markers dysfunction, after 5 years follow-up. Forty-nine function were submitted and simultaneous measurement serum creatinine (Cr). Histology evaluated using Banff scores, determination interstitial fibrosis by Sirius red staining immunohistochemical proximal tubule compartment (using cytokeratin, vimentin,...
Background. In acute renal failure (ARF) tubular cell death and detachment can be induced by necrotic apoptotic mechanisms. Several studies have demonstrated some benefits of the use growth factors in experimental models ARF. Methods. MDCK cells were cultured a glucose-free medium for 24 h submitted to hypoxia (pO2 around 35 mmHg) additional h. To evaluate possible protective role factors, EGF, IGF-I or HGF added (20 ng mL). LDH release, viability (acridine orange ethidium bromide dyes)...
Background Several factors influence the outcomes in acute kidney injury (AKI), especially intensive care unit (ICU) patients. In this scenario, continuous renal replacement therapies (CRRT) are used to control metabolic derangements and blood volume. Knowing fact, it may be possible change course of disease decrease high mortality rate observed. Thus, we aimed evaluate main risk for death AKI patients needing CRRT. Results This was a prospective, observational cohort study ICU (N = 183)...
Genetic variations in TGF- β and IFN- γ may interfere with proinflammatory cytokine production and, consequently, be involved inflammatory diseases, as acute kidney injury (AKI). We considered that genetic polymorphisms of these cytokines have a crucial role the outcome critically ill patients. To investigate whether rs1800470 (codon 10 T/C), rs1800471 25 C/G) from , rs2430561 (+874 T/A) risk factor for ICU patients to development AKI and/or death. In prospective nested case-control study,...
Performing a kidney biopsy is necessary to accurately diagnose diseases such as glomerulonephritis and tubulointerstitial nephritis, among other conditions. These conditions predispose patients chronic disease, well acute injury (AKI). Notably, most epidemiological studies describing AKI have not investigated this patient population. Included admitted the nephrology ward of tertiary hospital who underwent percutaneous biopsy. was diagnosed based on Kidney Disease: Improving Global Outcomes...
Abstract The use of regional citrate anticoagulation (RCA) in liver failure (LF) patients can lead to accumulation. We aimed evaluate serum levels and correlate them with function markers the Cat/Cai under intensive care undergoing continuous venovenous hemodiafiltration (CVVHDF-RCA). A prospective cohort study an unit was conducted. compared survival, clinical, laboratorial dialysis data between without LF. Citrate measured daily. evaluated 200 patients, 62 (31%) significantly higher LF...
Anemia is a common feature in critically ill patients. Serum soluble-Fas (sFas) levels are associated with anemia chronic kidney disease. It possible that sFas also acute injury (AKI) The study aims to investigate the relationship between serum of sFas, erythropoietin (Epo), inflammatory cytokines, and hemoglobin (Hb) concentration patients AKI. We studied 72 AKI (AKI group; n = 53) or without (non-AKI 19), 18 healthy volunteers. Epo, tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6,...
Introduction . Cystatin C has been used in the critical care setting to evaluate renal function. Nevertheless, it also found correlate with mortality, but is not clear whether this association due acute kidney injury (AKI) or other mechanism. Objective To serum cystatin at intensive unit (ICU) entry predicts AKI and mortality elderly patients. Materials Methods It was a prospective study of ICU patients without admission. We evaluated 400 based on normality for entry, whom 234 (58%) were...
Many controversies exist regarding the management of dialysis-requiring acute kidney injury (D-AKI). No clear evidence has shown that choice dialysis modality can change survival rate or function recovery critically ill patients with D-AKI.We conducted a retrospective study investigating (≥16 years old) admitted to an intensive care unit D-AKI from 1999 2012. We analyzed incidence, and outcomes, as well most commonly used over time. Outcomes were based on hospital mortality, renal (estimated...
Sepsis is the main cause of acute kidney injury (AKI) among individuals hospitalized in intensive care units. Acute an independent risk factor for mortality, and its occurrence increases complexity cost treatment. However, pathophysiological mechanisms AKI remain unclear. Hemodynamic, vascular, tubular, cellular, inflammatory, oxidative processes are involved. Individuals with generally have various comorbidities elderly hypercatabolic on vasopressors mechanical ventilation. Dialysis...
Infectious complications are common in systemic lupus erythematosus. Although uncommon, central nervous system infections do occur and have significant lethality, with several etiological agents.
Introduction Brazil is the largest Latin American country with a population of 211.75 million inhabitants as March 2020. São Paulo, capital city Paulo State, most economically developed and populous (12.25 inhabitants), it located in southeastern region (1). There unified public health system all over that has been implemented since 1993, provides care to about 80% relatively well organized, although insufficient, network basic primary units hospitals for higher-complexity cases. On other...
Metabolic acid–base disorders, especially metabolic acidosis, are common in critically ill patients who require renal replacement therapy. Continuous veno-venous hemodiafiltration (CVVHDF) achieves profound changes status, but acidosis can remain unchanged or even deteriorate some patients. The objective of this study is to understand the variables with septic associated acute kidney injury (SA-AKI) during CVVHDF and determine how they relate clinical outcome. Observational 200 subjects...