A5027342936- Acute Kidney Injury Research
- Erythropoietin and Anemia Treatment
- Muscle and Compartmental Disorders
- Hemoglobinopathies and Related Disorders
- Dialysis and Renal Disease Management
- COVID-19 Clinical Research Studies
- Cardiac Arrest and Resuscitation
- Iron Metabolism and Disorders
- Peripheral Artery Disease Management
- Erythrocyte Function and Pathophysiology
- Central Venous Catheters and Hemodialysis
- Blood properties and coagulation
- Glaucoma and retinal disorders
- Organ Donation and Transplantation
- Cardiac Imaging and Diagnostics
- Sepsis Diagnosis and Treatment
- Blood transfusion and management
- Cardiac, Anesthesia and Surgical Outcomes
- Renal and Vascular Pathologies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Artificial Intelligence in Healthcare
- Renal function and acid-base balance
- Abdominal Surgery and Complications
- Kruppel-like factors research
- Advanced Glycation End Products research
University of Beira Interior
2025
Hospital Israelita Albert Einstein
2019-2024
Universidade Federal de São Paulo
2010-2024
Universidade Federal de Sergipe
2023
Sorbonne Université
2022
Hospital do Rim e Hipertensão
2015-2022
Wake Forest University
2020
Forest Institute
2020
University Hospital of Bern
2019
Background COVID-19 is a multisystemic disorder that frequently causes acute kidney injury (AKI). However, the precise clinical and biochemical variables associated with AKI progression in patients severe remain unclear. Methods We performed retrospective study on 278 hospitalized who were admitted to ward intensive care unit (ICU) between March 2020 June 2020, at University Hospital, São Paulo, Brazil. Patients aged ≥ 18 years confirmed RT-PCR included. was defined according Kidney Disease...
Introduction Multicenter studies involving patients with acute kidney injury (AKI) associated the disease caused by new coronavirus (COVID-19) and treated renal replacement therapy (RRT) in developing countries are scarce. The objectives of this study were to evaluate demographic profile, clinical picture, risk factors for mortality, outcomes critically ill AKI requiring dialysis (AKI-RRT) COVID-19 megalopolis São Paulo, Brazil. Methods This multicenter, retrospective, observational was...
To evaluate the intraocular pressure and ocular perfusion during a hemodialysis.Sixty-seven eyes from thirty-five patients were evaluated at beggining of hemodialysis, 2 hours 4 after initiation. Intraocular was using Tonopen. Systolic diastolic arterial pressures measured with manual sphygmomanometer. The estimated by measuring difference between 2/3 mean values. Generalized estimating equations used to repeated measurements appropriate correction for inter-eye dependency.There no...
SUMMARY: Background: Nitric oxide (NO) released from endothelial cells is related to the maintenance of physiological vascular tone. The impairment NO generation brought about by gene polymorphism considered one deterioration factors in progressive renal disease. In nitric synthase (eNOS) intron 4 polymorphism, presence aa genotype has been associated with cardiovascular and aim this study was investigate eNOS patients end‐stage disease (ESRD). Methods: A total 114 94 controls were studied....
The objective of the present study is to evaluate association red blood cell distribution width with acute kidney injury in sepsis.This a retrospective 849 critically ill patients sepsis intensive care unit. Demographic data, renal function, inflammation, complete count, and acid-base parameters were compared between non-acute groups. Therefore, multivariate analysis was performed observe independent predictive factors.Comparatively, higher levels C-reactive protein, lactate, width,...
Abstract Aims In Europe, global data on guideline adherence, geographic variations, and determinants of clinical events in patients with chronic coronary syndrome (CCS) remain suboptimal. The European Society Cardiology (ESC) EURObservational Research Programme (EORP) Chronic Ischemic Cardiovascular Disease Long-Term (CICD-LT) registry is a prospective registry, was designed to describe the profile, management, outcomes CCS across ESC countries. Methods results We aimed investigate at 1-year...
Abstract Polymorphonuclear leukocytes (PMNs) from chronic kidney disease (CKD) patients display accelerated apoptosis and dysfunction, which may predispose CKD to infections. In this study, we investigated the effect of spermidine p‐cresol on function PMN healthy subjects. We measured apoptosis, ROS production unstimulated stimulated ( S. aureus PMA) expression CD95, caspase 3, CD11b PMN. After incubation with spermidine, did not observe any changes in viability or 3 CD95 incubated for 10...
Soluble Fas levels (sFas) are increased in the serum of uremic patients and associated with presence anemia recombinant human EPO (rHuEPO) dosage dialysis patients. It is possible that sFas an need for erythropoietin (Epo) chronic kidney disease order to maintain hematocrit (Hct) levels.To investigate relationship between levels, Epo ratio Hct patients.We studied 52 predialysis (CKD; 33 M, 57 +/- 12 years, = 37 7%), 29 peritoneal (PD; 54 14 36 hemodialysis (HD; 19 47 5%) healthy volunteers...
Anemia is a common feature in critically ill patients. Serum soluble-Fas (sFas) levels are associated with anemia chronic kidney disease. It possible that sFas also acute injury (AKI) The study aims to investigate the relationship between serum of sFas, erythropoietin (Epo), inflammatory cytokines, and hemoglobin (Hb) concentration patients AKI. We studied 72 AKI (AKI group; n = 53) or without (non-AKI 19), 18 healthy volunteers. Epo, tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6,...
Exacerbation of chronic glaucoma or acute is occasionally observed in patients undergoing hemodialysis (HD) because anterior chamber depth changes during this therapy.To evaluate and axial length HD sessions.A total 67 eyes 35 were prospectively enrolled. Axial measured using ultrasonic biometry, these measures evaluated at three different times sessions. Body weight blood pressure pre- post-HD also measured.There was no difference the between measurements (P = 0.241). We a significantly...
Purpose This study aimed to morphological and renal structural changes in relation different ischemic times types of vascular pedicle clamping. Methods Sixteen pigs were divided into two groups (n = 8): Group AV - unilateral clamping the artery vein A only, both with contralateral kidney used as control. Serial biopsies performed at 0, 10, 20, 30, 40, 50, 60, 70, 80, 90 minutes after Results there is a correlation between occurrence damage function time (p <0.001), higher frequency lesions...
Intestinal obstruction has a high mortality rate when therapeutic treatment is delayed. Resuscitation in intestinal requires large volume of fluid, and fluid combinations have been studied. Therefore, we evaluated the effects hypertonic saline solution (HS) with pentoxifylline (PTX) on apoptosis, oxidative stress survival rate.Wistar rats were subjected to ischemia through closed loop ligation terminal ileum its vessels. After 24 hours, necrotic bowel segment was resected, animals randomized...
Serum soluble Fas (sFas) levels are associated with erythropoietin (Epo) hyporesponsiveness in patients chronic kidney disease (CKD). Whether sFas could predict the need for erythropoiesis-stimulating agent (ESA) usage and its influence erythropoiesis remain unclear. We evaluated relation between ESA therapy CKD anemia effect on vitro. First, we performed a retrospective cohort study 77 anemic nondialysis CKD. vitro experiments to investigate whether interfere behavior of hematopoietic stem...
We observed a case of recombinant human erythropoietin resistance caused by Gastric Antral Vascular Ectasia in 40-year-old female with ESRD on hemodialysis. Some associated factors such as autoimmune disease, hemolysis, heart and liver disease were discarded physical examination complementary tests. The diagnosis is based the clinical history endoscopic appearance watermelon stomach. histologic findings are fibromuscular proliferation capillary ectasia microvascular thrombosis lamina...
This study aimed to compare the characteristics and outcomes of critically ill patients with COVID-19-associated acute kidney injury (AKI) who were treated replacement therapy (KRT) in first second waves pandemic megalopolis Sao Paulo, Brazil.A multicenter retrospective was conducted 10 intensive care units (ICUs). Patients aged ≥18 years, KRT due AKI included. We compared demographic, laboratory clinical data, parameters patient COVID-19 waves.We assessed 656 (327 wave 329 one). Second-wave...
Purpose Increased serum concentrations of soluble Fas (sFas) have been reported in patients with chronic kidney disease (CKD). However, little is known about the renal clearance sFas, whether sFas reabsorbed tubules, or behavior synthesis CKD. Materials and Methods We studied 69 CKD (60±15 years old, creatinine 37+19 ml/min/1.73 m 2 ) 14 healthy subjects (61±17 years, 79±24 ). ELISA was used to measure levels (pg/mL) retinol binding protein (RBP - mg/L). RT-PCR quantify sFasmRNA leukocytes....
Patients with chronic kidney disease (CKD) stage 5D suffer from the accumulation of uremic toxins. The treatment hemodiafiltration (HDF) demonstrates highest capacity for removing solutes small and middle molecular weight, as well improving mortality. While exercise has been proven an adjunct therapy in patients on maintenance hemodialysis, little is known about influence HDF programs. Objectives: Assess impact physical performance patient-reported outcomes regimen.
Abstract Background and Aims Individuals with chronic kidney disease (CKD) stage 5D face challenges due to the accumulation of uremic toxins. Hemodiafiltration (HDF) stands out for its efficacy in removing solutes various molecular weights, offering mortality benefits. Although exercise rehabilitation is established as a beneficial adjunct therapy patients on maintenance hemodialysis, impact HDF programs remains understudied. The primary aim was evaluate safety undergoing HDF. secondary...
RESUMO Introdução: A anemia é frequente em pacientes submetidos à terapia substitutiva para insuficiência renal. nos períodos pré e pós-transplante pode estar relacionada aos desfechos do transplante Portanto, o presente estudo buscou avaliar a relação entre anemia, função retardada enxerto (FRE), disfunção crônica renal (DCE) óbito por qualquer causa após de doador falecido. Métodos: Este foi um retrospectivo com 206 transplantados renais doadores falecidos. Analisamos dados demográficos...
ABSTRACT Introduction: Anemia is frequent in patients undergoing replacement therapy for kidney failure. the pre- and post-transplantation period might be related to transplant outcomes. The current study therefore sought assess relationship between anemia, delayed allograft function (DGF), chronic dysfunction (CAD), death from any cause following transplantation a deceased donor. Methods: This was retrospective with 206 of donors. We analyzed donors’ patients’ demographic data. Moreover, we...