Grégoire Rangé
A5016160566- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Cardiovascular Issues in Pregnancy
- Health Systems, Economic Evaluations, Quality of Life
- Peripheral Artery Disease Management
- Mechanical Circulatory Support Devices
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 and healthcare impacts
- Cardiac Health and Mental Health
- Healthcare cost, quality, practices
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Aortic aneurysm repair treatments
- Cardiac Arrest and Resuscitation
- Healthcare Systems and Practices
Les Hôpitaux de Chartres
2016-2025
Université Claude Bernard Lyon 1
2020-2024
Hôpital Xavier Arnozan
2024
Assistance Publique – Hôpitaux de Paris
2014-2024
Hôpital Européen Georges-Pompidou
2024
Université Paris Cité
2024
Inserm
2014-2024
Hôpital Lariboisière
2024
Hôpital Pasteur
2014-2023
University of Liverpool
2021-2022
Patients' responses to oral antiplatelet therapy are subject variation. Bedside monitoring offers the opportunity improve outcomes after coronary stenting by individualizing therapy.
Experimental and clinical evidence suggests that cyclosporine may attenuate reperfusion injury reduce myocardial infarct size. We aimed to test whether would improve outcomes prevent adverse left ventricular remodeling.In a multicenter, double-blind, randomized trial, we assigned 970 patients with an acute anterior ST-segment elevation infarction (STEMI) who were undergoing percutaneous coronary intervention (PCI) within 12 hours after symptom onset had complete occlusion of the culprit...
Angiography has limited value for identifying the causes of stent thrombosis (ST). We studied a large cohort patients by optical coherence tomography (OCT) to explore ST characteristics and mechanisms.A prospective multicentre registry was screened with confirmed ST. Optical performed after initial intervention culprit lesion (in 69% cases in deferred procedure). Stent classified as acute (AST), sub-acute (SAST), late (LST), very (VLST). records were analysed central core lab. The analysis...
In patients with ST-elevation myocardial infarction (STEMI) who have multivessel disease, percutaneous coronary intervention (PCI) for nonculprit lesions (complete revascularization) is superior to treatment of the culprit lesion alone. However, whether complete revascularization that guided by fractional flow reserve (FFR) an angiography-guided procedure unclear.
The appropriate duration of treatment with beta-blocker drugs after a myocardial infarction is unknown. Data are needed on the safety and efficacy interruption long-term to reduce side effects improve quality life in patients history uncomplicated infarction.
Background— Delayed stent implantation after restoration of normal epicardial flow by a minimalist immediate mechanical intervention aims to decrease the rate distal embolization and impaired myocardial reperfusion percutaneous coronary intervention. We sought confirm whether delayed stenting (DS) approach (24–48 hours) improves reperfusion, versus stenting, in patients with acute ST-segment–elevation infarction undergoing primary Methods Results— In prospective, randomized, open-label...
Gregoire Range, MD, Radwan Hakim, Pascal Motreff, PhD; Where have the STEMIs gone during COVID-19 lockdown?, European Heart Journal - Quality of Care a
Intravascular ultrasound (IVUS)-guided PCI improves the prognosis of left main stem (LMS) and is currently recommended by international guidelines. Although OCT resolution greater than that IVUS, this tool not yet in LMS angioplasty due to absence data.This pilot study aimed analyse feasibility, safety impact OCT-guided PCI.This prospective, multicentre trial investigated whether patients might benefit from for mid/distal according a pre-specified protocol. The primary endpoint was...
Spontaneous coronary artery dissection (SCAD) is an increasingly reported but poorly understood condition. Few European data are available.The aims of this study were to obtain on SCAD, determine the prevalence fibromuscular dysplasia (FMD) and enable genetic analyses in population.Data from a national French registry SCAD cases analysed prospectively retrospectively. Clinical angiographic management strategy collected. Major adverse cardiovascular events (MACE) after one year follow-up....
Background— Individualizing antiplatelet therapy after platelet function testing did not improve outcome coronary stenting in the Assessment by a Double Randomization of Conventional Antiplatelet Strategy Versus Monitoring-Guided for Drug-Eluting Stent Implantation and Treatment Interruption Continuation One Year After Stenting (ARCTIC) study. Whether results are different during phase secondary prevention starting hospital discharge, when periprocedural events have been excluded, is...
Morphine is commonly used to treat chest pain during myocardial infarction, but its effect on cardiovascular outcome has never been directly evaluated. The aim of this study was examine the and safety morphine in patients with acute anterior ST-segment elevation infarction followed up for 1 year.We database CIRCUS (Does Cyclosporine Improve Outcome ST Elevation Myocardial Infarction Patients) trial, which included 969 admitted primary percutaneous coronary intervention. Two groups were...
Chronic kidney disease (CKD) is one of the leading causes death worldwide, closely interrelated with cardiovascular diseases, ultimately to failure both organs - so-called "cardiorenal syndrome". Despite this burden, data related cardiogenic shock outcomes in CKD patients are scarce.
In patients with multivessel disease successful primary percutaneous coronary intervention for ST-segment-elevation myocardial infarction, the FLOWER-MI trial (Flow Evaluation to Guide Revascularization in Multivessel ST-Elevation Myocardial Infarction) showed that a fractional flow reserve (FFR)-guided strategy was not superior an angiography-guided treatment of noninfarct-related artery lesions regarding 1-year risk death from any cause, or unplanned hospitalization leading urgent...
The aim of this study was to assess the impact coronavirus disease 2019 (COVID-19) outbreak on incidence, delays, and outcomes ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PPCI) in France.We analyzed all PPCI <24 hours STEMI included prospective France PCI registry. 2 groups were compared mean monthly number patients, delays pathway care, in-hospital major adverse cardiac events (MACE: death, stent thrombosis, infarction,...