A5017722452- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Aortic Disease and Treatment Approaches
- Cardiovascular Function and Risk Factors
- Venous Thromboembolism Diagnosis and Management
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Viral Infections and Immunology Research
- Cardiac Ischemia and Reperfusion
- Advanced MRI Techniques and Applications
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Congenital Heart Disease Studies
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Arrest and Resuscitation
- Peripheral Artery Disease Management
- Healthcare Systems and Practices
- Cardiac, Anesthesia and Surgical Outcomes
- Transplantation: Methods and Outcomes
- Advanced X-ray and CT Imaging
Université de Rouen Normandie
2016-2025
Inserm
2013-2025
Centre Hospitalier Universitaire de Lille
2024
Centre Hospitalier Intercommunal André Grégoire Montreuil
2024
Université de Limoges
2024
Institut Pasteur de Lille
2024
Normandie Université
2017-2023
Centre Hospitalier Universitaire de Rouen
2010-2022
Hôpital Charles-Nicolle
2021
Endothélium, valvulopathies et insuffisance cardiaque
2020
Background— The design of a percutaneous implantable prosthetic heart valve has become an important area for investigation. A percutaneously implanted (PHV) composed 3 bovine pericardial leaflets mounted within balloon-expandable stent was developed. After ex vivo testing and animal implantation studies, the first human performed in 57-year-old man with calcific aortic stenosis, cardiogenic shock, subacute leg ischemia, other associated noncardiac diseases. Valve replacement had been...
Experimental and clinical evidence suggests that cyclosporine may attenuate reperfusion injury reduce myocardial infarct size. We aimed to test whether would improve outcomes prevent adverse left ventricular remodeling.In a multicenter, double-blind, randomized trial, we assigned 970 patients with an acute anterior ST-segment elevation infarction (STEMI) who were undergoing percutaneous coronary intervention (PCI) within 12 hours after symptom onset had complete occlusion of the culprit...
Repetitive, brief periods of ischemia and reperfusion ("preconditioning") increase the resistance myocardial tissue to subsequent prolonged ischemic episodes limit infarct size. We investigated whether preconditioning also protects against coronary endothelial dysfunction induced by reperfusion.Experiments were performed in four groups rats (n = 8 each group): group 1 underwent sham surgery, 2 subjected 20 minutes left artery occlusion without reperfusion, 3 followed hour 4 (preconditioning...
There is currently no consensus on the duration of hospitalization required after transfemoral transcatheter aortic valve implantation (TAVI). We report feasibility and safety early discharge TAVI with Edwards SAPIEN-XT prosthesis. From 2009 to 2013, 337 patients underwent prosthesis using local anesthesia were discharged home either (≤3 days, Early Discharge group, n = 121) or 3 days (Late 216). The primary end point study combined death rehospitalization from 30-day follow-up. Patients in...
The newly developed percutaneous heart valve (PHV) implantation technique decreases transaortic pressure gradient in patients with aortic stenosis. PHV replacement effects on left ventricular (LV) global and regional systolic function are currently unknown.Eight severe stenosis had 2D echocardiography at baseline 24 hours after to evaluate changes LV volume ejection fraction. Regional function, ie, both peak anterior posterior wall tissue velocity, as well strain rate imaging, were measured...
<h3>Objectives</h3> To evaluate the incidence, predictors and impact of bleeding after transcatheter aortic valve implantation (TAVI). <h3>Design</h3> Single-centre prospective observational study. <h3>Setting</h3> Charles Nicolle University Hospital, Rouen, France. <h3>Interventions</h3> We included 250 consecutive patients who underwent TAVI between May 2006 October 2011. All procedures were performed using Edwards SAPIEN XT valves via transfemoral (TF) transapical (TA) routes. Surgical...
Durability of transcatheter aortic bioprosthetic valves remains a major issue. Standardised definitions deterioration and failure have recently been proposed. The aim this study was to assess structural valve (SVD) (BVF) using these new definitions.All TAVI patients implanted up September 2012 with minimal theoretical five-year follow-up were included. Systematic clinical echocardiographic performed annually. New standardised used durability valves. From 2002 2012, 378 Mean age logistic...
Background: The durability of transcatheter aortic bioprosthetic valves is a crucial issue, but data are scarce, especially beyond 5 years follow-up. We aimed to assess long-term (7 years) structural valve deterioration (SVD) and failure valves. Methods Results: Consecutive patients with at least 5-year follow-up available undergoing implantation from April 2002 December 2011 in French centers were included. Incidence SVD defined according newly standardized criteria the European Association...
Background The rheolytic thrombectomy catheter has been specially designed to remove intravascular thrombus from coronary and peripheral arteries. It demonstrates a practical application of Bernoulli’s principle relating low-pressure zone in the region high-velocity jet. In this device, effect is created by direct high-pressure saline jets located at tip. Thrombus drawn into and, because large pressure difference, undergoes mechanical thrombolysis due powerful mixing forces. resulting...
Transcatheter aortic valve replacement (TAVR) is a promising therapeutic option for patients with severe stenosis (AS) considered at too high risk conventional replacement. The balloon-expandable Edwards can be implanted using either the transfemoral or transapical routes, depending on arterial ilio-femoral suitability. aim of study was to evaluate usefulness angiography as an initial screening tool TAVR approach SAPIEN valve.Aortography bilateral run-off assessed in antero-posterior...
Morphine is commonly used to treat chest pain during myocardial infarction, but its effect on cardiovascular outcome has never been directly evaluated. The aim of this study was examine the and safety morphine in patients with acute anterior ST-segment elevation infarction followed up for 1 year.We database CIRCUS (Does Cyclosporine Improve Outcome ST Elevation Myocardial Infarction Patients) trial, which included 969 admitted primary percutaneous coronary intervention. Two groups were...
Abstract Background/Objective Prostar XL (PS) and ProGlide (PG) are common vascular closure devices (VCD) used in TAVR via transfemoral approach. The impact of these VCD on bleeding complications remains unclear. Methods BRAVO‐3 trial randomized 802 patients undergoing TAVR. We stratified according to type examined the 30‐day incidence major or minor complications, (BARC ≥3b), AKI adverse cardiac cerebrovascular events (MACCE; death, myocardial infarction stroke). Results A total 746 (93%)...