A5065395637- Cardiovascular Issues in Pregnancy
- Cardiac Structural Anomalies and Repair
- Coronary Artery Anomalies
- Corporate Taxation and Avoidance
- Aortic Disease and Treatment Approaches
- Connective tissue disorders research
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Mechanical Circulatory Support Devices
- Renal and Vascular Pathologies
- Peptidase Inhibition and Analysis
- Metabolism, Diabetes, and Cancer
- Vascular Procedures and Complications
- Vascular anomalies and interventions
- Kawasaki Disease and Coronary Complications
- Cardiovascular Health and Disease Prevention
- Cardiomyopathy and Myosin Studies
- Infective Endocarditis Diagnosis and Management
- Viral Infections and Immunology Research
- Cardiac Health and Mental Health
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Organ Transplantation Techniques and Outcomes
- Cardiac Valve Diseases and Treatments
- Transplantation: Methods and Outcomes
- Cerebrovascular and Carotid Artery Diseases
Victor Chang Cardiac Research Institute
2021-2025
St Vincent's Hospital Sydney
2016-2025
UNSW Sydney
2018-2024
St Vincent's Health
2024
St Vincent's Clinic
2018-2023
St Vincent's Hospital
2020-2023
Spontaneous coronary artery dissection (SCAD) is an uncommon but serious condition presenting as acute syndrome (ACS) or cardiac arrest. The pathophysiology and outcomes are poorly understood. We investigated the characteristics of patients with SCAD.In a retrospective study large cohort SCAD, data were collected regarding clinical presentation, patient characteristics, vascular screening, involvement outcomes.40 SCAD (95% women, mean age 45±10 years) included. At least 1 traditional...
Spontaneous coronary artery dissection (SCAD) occurs when an epicardial is narrowed or occluded by intramural hematoma. SCAD mainly affects women and associated with pregnancy systemic arteriopathies, particularly fibromuscular dysplasia. Variants in several genes, such as those causing connective tissue disorders, have been implicated; however, the genetic architecture poorly understood. Here, we aim to better understand diagnostic yield of rare variant testing among a cohort survivors...
Spontaneous coronary artery dissection (SCAD) is a cause of acute syndrome that predominantly affects women. Its pathophysiology remains unclear but connective tissue disorders (CTD) and other vasculopathies have been observed in many SCAD patients. A genetic component for increasingly appreciated, although few genes robustly implicated. We sought to clarify the using targeted genome-wide methods cohort sporadic cases identify both common rare disease-associated variants.
Severe coronary tortuosity has previously been linked to low shear stresses at the luminal surface, yet this relationship is not fully understood. Several previous studies considered different metrics when exploring its impact of on wall stress (WSS), which likely contributed ambiguous findings in literature. Here, we aim analyze determine a benchmark for highest correlating metric with time-averaged WSS (TAWSS). Using Computed Tomography Coronary Angiogram (CTCA) data from 127 patients...
Studies have shown marked sex disparities in Coronary Artery Diseases (CAD) epidemiology, yet the underlying mechanisms remain unclear. We explored coronary anatomy and resulting haemodynamics patients with suspected but no significant CAD. Left Main (LM) bifurcations were 3D-reconstructed from 127 Computed Tomography Angiography images (42 males 85 females, aged 38-81). Shape parameters including bifurcation angles, curvature, diameters measured, before solving clinically relevant...
Spontaneous coronary artery dissection (SCAD) is an increasingly recognised cause of acute syndrome predominantly affecting women (>90% cases) that frequently associated with other arteriopathies, such as fibromuscular dysplasia (FMD) and migraine. We present a case multi-vessel SCAD in woman her 40s presenting myocardial infarction whom incidental widespread FMD was found, including massive right renal aneurysm requiring ex vivo resection, repair autotransplantation. The underscores the...
Mobile valvular masses are often considered pathognomonic for infective endocarditis. We present a case of young patient with mobile in the context myocarditis likely secondary to active ileal Crohn's disease. Cardiac magnetic resonance (CMR) imaging was crucial diagnosing and monitoring our patient.A 27-year-old woman presented pleuritic chest pain, dyspnoea, 3-day history fevers. She also reported 2-month intermittent visual loss her right eye. had histologically proven disease, diagnosed...
Abstract Background There is increasing evidence that patients with spontaneous coronary artery dissection (SCAD) have an underlying genetic susceptibility (Goel et al JAMA Intern Med175:821–826, 2015). Moreover, in a collaborative study involving 1,055 SCAD cases and 7,190 controls, we recently reported the first risk allele for SCAD, variant (rs9349379-A) PHACTR1/EDN1 locus (Adlam J Amer Coll Cardiol73:58–66, 2019). Purpose We sought to determine clinical characteristics initial data 11...
• Cardiac allograft vasculopathy is a leading cause of death after heart transplantation. Whilst CT coronary angiogram and stress echocardiography can provide useful information about the arterial lumen wall, invasive angiography with physiology studies remains gold standard. Ongoing investigation into non-invasive imaging required before it widely adopted as part cardiac screening program for transplantation patients.
Abstract Background Spontaneous coronary artery dissection (SCAD) affects mainly women with a mean age of 51 years.(1) Predicted damaging variants in connective tissue disease (CTD) genes have been found subset patients SCAD, however some cases the typical phenotype associated these conditions is lacking. Variants COL3A1 gene, on chromosome 2 encoding type III collagen, appear to be one most frequently reported SCAD. Mutations alter production and structure procollagen weaken tissues,...
Studies have shown marked sex disparities in Coronary Artery Diseases (CAD) epidemiology, yet the underlying mechanisms remain unclear. We explored coronary anatomy and resulting haemodynamics patients with suspected, but no significant CAD. Left Main (LM) bifurcations were reconstructed from CTCA images of 127 cases (42 males 85 females, aged 38 to 81). Detailed shape parameters measured for comparison, including bifurcation angles, curvature, diameters, before solving haemodynamic metrics...