A5050116475- Cardiovascular Issues in Pregnancy
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Coronary Artery Anomalies
- Cardiac Health and Mental Health
- Heart Failure Treatment and Management
- Vascular Procedures and Complications
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Arrest and Resuscitation
- Infective Endocarditis Diagnosis and Management
- Diversity and Career in Medicine
- Australian History and Society
- Central Venous Catheters and Hemodialysis
- Respiratory Support and Mechanisms
- Infectious Aortic and Vascular Conditions
- Healthcare professionals’ stress and burnout
- Cardiac, Anesthesia and Surgical Outcomes
- Pericarditis and Cardiac Tamponade
- Cardiovascular Effects of Exercise
- Corporate Taxation and Avoidance
- Abdominal vascular conditions and treatments
- Connective tissue disorders research
- Atherosclerosis and Cardiovascular Diseases
- Opioid Use Disorder Treatment
University of Leicester
2017-2024
University Hospitals of Leicester NHS Trust
2014-2024
Glenfield Hospital
2011-2023
NIHR Leicester Biomedical Research Centre
2019-2022
National Institute for Health Research
2019-2022
Canberra Hospital
2016
Google (United States)
2016
WellStar Kennestone Hospital
2012
Norfolk and Norwich University Hospital
2010
University Hospital of Geneva
2005-2007
Spontaneous coronary artery dissection (SCAD) occurs when an epicardial is narrowed or occluded by intramural hematoma. SCAD mainly affects women and associated with pregnancy systemic arteriopathies, particularly fibromuscular dysplasia. Variants in several genes, such as those causing connective tissue disorders, have been implicated; however, the genetic architecture poorly understood. Here, we aim to better understand diagnostic yield of rare variant testing among a cohort survivors...
To investigate percutaneous coronary intervention (PCI) practice in an international cohort of patients with spontaneous artery dissection (SCAD). explore factors associated complications and study angiographic longer term outcomes.SCAD (n=215, 94% female) who underwent PCI from three national studies were investigated compared a matched conservatively managed SCAD (n=221).SCAD-PCI high risk at presentation only 8.8% undergoing outside the context ST-elevation myocardial infarction/cardiac...
To report the extent and distribution of myocardial injury its impact on left ventricular systolic function with cardiac magnetic resonance imaging (CMR) following spontaneous coronary artery dissection (SCAD) to investigate predictors injury.One hundred fifty-eight angiographically confirmed SCAD-survivors (98% female) were phenotyped by CMR compared in a case-control study 59 (97% healthy controls (44.5 ± 8.4 vs. 45.0 9.1 years). Spontaneous presentation was non-ST-elevation infarction 95...
Abstract Aims Women’s participation is steadily growing in medical schools, but they are still not sufficiently represented cardiology, particularly cardiology leadership positions. We present the contemporary distribution of women leaders departments World Health Organization European region. Methods and results Between August December 2020, we applied purposive sampling to collect data analyse gender heads department university/third level hospitals 23 countries: Austria, Azerbaijan,...
In Brief We present the case of a 66-yr-old woman who was admitted to surgical intensive care unit with life-threatening rectal bleeding. Despite use angiography and repeated computed tomography scans, diagnosis primary aortoduodenal fistula secondary an abdominal aortic aneurysm not made, leading delay in until time surgery. The reliability radiological investigations importance being alert possibility this extremely rare condition are discussed. IMPLICATIONS: describe delayed related...
Although the lungs are potentially highly susceptible to post-cardiac arrest syndrome injury, issue of acute respiratory failure after out-of-hospital cardiac has not been investigated. The objectives this analysis were determine prevalence arrest, its association with inflammatory response and clarify importance for early mortality.The Post-Cardiac Arrest Syndrome (PCAS) pilot study was a prospective, observational, six-centre project (Poland 2, Denmark 1, Spain Italy UK 1), studying...
Although infective endocarditis (IE) represents a unique model of thrombo-inflammatory disease, the most frequent early complications surgical valve replacement (SVR) in IE population are coagulopathy and bleeding. The hemostatic capacity procedure-related coagulation disorders patients undergoing SVR unknown. aims this study were to test periprocedural hemostasis urgent SVR, assess association between bleeding as well with thromboembolic events.A prospective, two-center, hypothesis...
Abstract Aims The non-coding locus at 6p24 located in Intron 3 of PHACTR1 has consistently been implicated as a risk allele myocardial infarction and multiple other vascular diseases. Recent murine studies have identified role for Phactr1 the development atherosclerosis. However, tone vivo remodelling yet to be established. aim this study was investigate function. Methods results Prospectively recruited coronary artery disease (CAD) patients undergoing bypass surgery retrospectively...
Abstract Perforation and disruption of the artery used for access is a recognized complication coronary angiography. There an increasing trend toward use radial angiography angioplasty, particularly in primary angioplasty setting, because reduced risk hemorrhagic complications. On rare occasions when perforation occurs, operators have had tendency to switch second arterial route. This article describes technique managing peri‐procedural which does not require access. We show two cases where...
A 37-year-old woman was admitted into the coronary care unit following chest pain after using cocaine. She found to have significant myocardial ischaemia on blood and ECG investigations despite a recent angiogram that had not demonstrated flow-limiting disease. This case report summarises risks of and/or infarction for patients taking cocaine pathophysiology behind it, focusing in particular delayed reaction some time ingestion.
Abstract Background Dilated cardiomyopathy (DCM) has a poor prognosis. Aerobic exercise capacity (peak VO2) is an independent predictor of mortality but the central mechanisms contributing to intolerance in DCM are unknown. Purpose To characterise myocardial perfusion reserve (MPR) and determine if cardiovascular magnetic resonance (CMR) measures structure, function microvascular associated with aerobic DCM. Methods Single centre, prospective, case-control comparison adults matched controls....
Women remain under-represented in cardiology and one frequently cited concern is that of radiation exposure pregnancy.1 This article aims to clarify the actual risks pregnant cardiologists describe how these can be mitigated. X-rays are at short-wave end electromagnetic spectrum produce high-frequency energy which ionise atoms. The effective dose measured Sievert, defined as whole-body weighted by organ sensitivity. In pregnancy, there concerns about risk fetus also less recognised...
Abstract Background/Introduction SCAD is a rare cause of acute coronary syndrome. Approximately 90% patients are women, and factors such as the hormonal changes menstrual cycle thought to be relevant. It therefore interesting consider why without exposure may affected. in men remains poorly understood. Purpose To study clinical features natural history see how it differs from women. Methods Patients with were recruited by self-referral clinician referral across UK. Angiograms reviewed two...