A5084472384- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Mechanical Circulatory Support Devices
- Lipoproteins and Cardiovascular Health
- Cardiac Arrest and Resuscitation
- Cardiac Valve Diseases and Treatments
- Takotsubo Cardiomyopathy and Associated Phenomena
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular and Diving-Related Complications
- Coronary Interventions and Diagnostics
- Transplantation: Methods and Outcomes
- Inflammasome and immune disorders
- Atrial Fibrillation Management and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac pacing and defibrillation studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Health and Mental Health
- Cardiovascular and exercise physiology
- Cardiac electrophysiology and arrhythmias
Sorbonne Université
2019-2025
Inserm
2019-2025
Assistance Publique – Hôpitaux de Paris
2019-2025
Fondation pour l’innovation en Cadiométabolisme et Nutrition
2019-2024
Unité de recherche sur les maladies cardiovasculaires et métaboliques
2019-2024
Hôpital Européen Georges-Pompidou
2024
Université Paris Cité
2024
Hôpital Lariboisière
2024
Pitié-Salpêtrière Hospital
2019-2024
Université Paris 1 Panthéon-Sorbonne
2020-2024
The appropriate duration of treatment with beta-blocker drugs after a myocardial infarction is unknown. Data are needed on the safety and efficacy interruption long-term to reduce side effects improve quality life in patients history uncomplicated infarction.
Abstract Aims Epicardial adipose tissue (EAT) could contribute to the specific atherosclerosis profile observed in premature coronary artery disease (pCAD) characterized by accelerated plaque burden (calcified and non-calcified), high-risk (HRP) features, ischaemic recurrence. Our aims were describe EAT volume density pCAD compared with asymptomatic individuals matched on cardiovascular risk factors study their relationship severity extension vulnerability. Methods results Two hundred eight...
Abstract Background Current guidelines fail to adequately identify and prevent cardiovascular prevention in young adults, even when a family history of disease (CVD) is known. Purpose We aim assess the feasibility acceptability routine family-based risk assessment first-degree relatives individuals with premature coronary artery (CAD). Methods Patients CAD were prospectively asked about pre-existing CVD cases previous check-ups among their relatives. They then encouraged invite healthy naïve...
Abstract Background There are currently no data regarding pre-treatment with P2Y12 inhibitors in patients acute myocardial infarction complicated cardiogenic shock (AMI-CS). This study investigates the effectiveness and safety of AMI-CS. Methods Results Using ACTION-SHOCK cohort, we included consecutive hospitalized between 2012 2023 AMI-CS admitted for coronary angiography within 24 hours admission. Pre-treatment was defined by administration before an oral loading dose a inhibitor. We...
The European Society of Cardiology (ESC) has released three consecutive guidelines within 5 years addressing cardiovascular prevention, risk scores, and cholesterol treatment. This study aims to evaluate whether the 2021 ESC improved eligibility individuals for primary prevention statin therapy before their first ST-segment elevation myocardial infarction (STEMI), intensive lipid-lowering treatments in secondary prevention.The category 2757 admitted a STEMI was evaluated assess they would...
Abstract Aims Premature coronary artery disease (CAD) is an aggressive with multiple recurrences mostly related to new lesions. This study aimed compare plaque characteristics of individuals premature CAD those incidental plaques found in matched free overt cardiovascular disease, using computed tomography angiography (CCTA). Methods and results Of 1552 consecutive who underwent CCTA, 106 history acute or stable obstructive ≤45 years were by age, sex, smoking status, heredity, dyslipidaemia...
Abstract Aims Low cholesterol efflux capacity (CEC) and elevated levels of interleukin-1ß (IL-1ß) are both associated with residual cardiovascular risk in patients acute myocardial infarction (MI) may be used as new biomarkers to identify at higher risk. Methods results We evaluated potential synergetic effect CEC IL-1ß on recurrent major adverse events (MACE) 1 year 2012 ST-segment elevation MI who underwent primary percutaneous coronary intervention. In addition, we the contribution HDL...
Abstract Patients’ prognostication around cardiac surgery is key to better assess risk–benefit balance. Preoperative brain natriuretic peptide (BNP) biomarker has been associated with mortality after surgery, but its added value EuroScore 2 remains be confirmed. In a prospective registry cohort of 4,980 patients undergoing the prognostic performance and preoperative BNP was assessed regarding postoperative in-hospital mortality. Discrimination feature evaluated using...
To determine if the changes in European Society Cardiology/European Atherosclerotic (ESC/EAS) guidelines improved identification for primary prevention therapy young adults at risk of a premature myocardial infarction.Patients admitted first ST-segment elevation infarction (STEMI) ePARIS registry (n=2757) between 2010 and 2018 were classified by age: <55, 55-65 >65 years old. Using Systematic Coronary Risk Estimation 2, we evaluated whether patients would have been detected treated with...
Abstract Background Higher rates of thrombotic events have been reported in myocardial infarction (MI) patients requiring blood transfusion. The impact transfusion strategy on thrombosis and inflammation is still unknown. Objective To compare the a liberal vs. restrictive P2Y12 platelet reactivity biomarkers multicentric randomized REALITY trial. Methods Patients to (hemoglobin ≤10 g/dL) or ≤8 had VASP-PRI measured centrally blinded fashion unit (PRU) locally using encrypted VerifyNow; at...
Abstract Background Coronary microvascular dysfunction is an heterogenous entity with structural present in about 60% of cases. Although Flow Reserve (CFR) commonly used for diagnosis, this index nonspecific to the microvasculature. The effectiveness recently introduced Microvascular Resistance (MRR) and absolute resistance (Rµ) identifying endotypes remains uncertain. Objective To evaluate whether MRR hyperemic Rµ assessment are effective dichotomizing functional as compared coronary blood...
Abstract BACKGOUND Patients with Angina and Non-Obstructive Coronary Artery disease (ANOCA) face misdiagnosis inadequate treatment. A new continuous thermodilution method enables assessment of absolute coronary blood flow (Q) microvascular resistance (Rµ). The effectiveness saline-induced hyperemia in capturing exercise-induced regulation remains unknown. OBJECTIVE To describe Q Rµ adaptation during exercise to explore the correlation between Flow Reserve (CFR) derived from saline hyperemia,...