Muh Geot Wong
A5044094477- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Platelet Disorders and Treatments
- Diabetes Treatment and Management
- Erythropoietin and Anemia Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Health Systems, Economic Evaluations, Quality of Life
- Birth, Development, and Health
- Hemoglobinopathies and Related Disorders
- Central Venous Catheters and Hemodialysis
- Autoimmune Bullous Skin Diseases
- Blood Pressure and Hypertension Studies
- Microbial metabolism and enzyme function
- Renal and related cancers
- Chronic Lymphocytic Leukemia Research
- Cardiac Arrhythmias and Treatments
- Pregnancy and preeclampsia studies
- Muscle and Compartmental Disorders
- Renal and Vascular Pathologies
- Complement system in diseases
- Atrial Fibrillation Management and Outcomes
- Nitric Oxide and Endothelin Effects
- Renin-Angiotensin System Studies
- Pancreatic function and diabetes
The George Institute for Global Health
2016-2025
Concord Repatriation General Hospital
2022-2025
The University of Sydney
2016-2025
UNSW Sydney
2017-2025
Royal North Shore Hospital
2014-2024
Concord Hospital
2024
Hospital Selayang
2023
University of Leicester
2023
Westmead Hospital
2022-2023
Westmead Institute
2023
<h3>Importance</h3> Guidelines recommend corticosteroids in patients with IgA nephropathy and persistent proteinuria, but the effects remain uncertain. <h3>Objective</h3> To evaluate efficacy safety of at risk progression. <h3>Design, Setting, Participants</h3> The Therapeutic Evaluation Steroids Nephropathy Global (TESTING) study was a multicenter, double-blind, randomized clinical trial designed to recruit 750 participants (proteinuria greater than 1 g/d estimated glomerular filtration...
The Action in Diabetes and Vascular Disease: Preterax Diamicron MR Controlled Evaluation (ADVANCE) trial reported that intensive glucose control prevents end-stage kidney disease (ESKD) patients with type 2 diabetes, but uncertainty about the balance between risks benefits exists. Here, we examine long-term effects of on risk ESKD other outcomes.Survivors, previously randomized to or standard control, were invited participate post-trial follow-up. ESKD, defined as need for dialysis...
The effect of glucocorticoids on major kidney outcomes and adverse events in IgA nephropathy has been uncertain.To evaluate the efficacy effects methylprednisolone patients with at high risk function decline.An international, multicenter, double-blind, randomized clinical trial that enrolled 503 participants nephropathy, proteinuria greater than or equal to 1 g per day, estimated glomerular filtration rate (eGFR) 20 120 mL/min/1.73 m2 after least 3 months optimized background care from 67...
A proliferation-inducing ligand (APRIL) is implicated in the pathogenesis of IgA nephropathy. Sibeprenlimab a humanized IgG2 monoclonal antibody that binds to and neutralizes APRIL.
An unmet need exists for focal segmental glomerulosclerosis (FSGS) treatment. In an 8-week, phase 2 trial, sparsentan, a dual endothelin–angiotensin receptor antagonist, reduced proteinuria in patients with FSGS. The efficacy and safety of longer-term treatment sparsentan FSGS are unknown. Download PDF the Research Summary. this 3 we enrolled (without known secondary causes) who were 8 to 75 years age; randomly assigned receive or irbesartan (active control) 108 weeks. surrogate end point...
The very high educational attainments of Asian-Americans have roots in the pre- World War II era. Native-born Chinese- and Japanese-Americans reached parity with majority whites early decades twentieth century. In this paper, we present an analysis interpretation structural conditions that may favored progress spite considerable societal discrimination. Changes occupational structure Asian-American population a somewhat positive rate returns to education appear be plausible explanations for...
Multiple rodent models have been used to study diabetic kidney disease (DKD). The purpose of the present was compare diabetes and obesity-induced metabolic syndrome determine differences in renal outcomes. C57BL/6 male mice were fed either normal chow or high fat diet (HFD). At postnatal week 8, chow-fed randomly assigned low-dose streptozotocin (STZ, 55 mg/kg/day, five consecutive days) vehicle control, whereas HFD-fed given one high-dose STZ (100 mg/kg) control. Intraperitoneal glucose...
Sparsentan is a novel single-molecule dual endothelin angiotensin receptor antagonist with hemodynamic and anti-inflammatory properties not an immunosuppressant. The ongoing phase 3 PROTECT trial examines sparsentan in adults IgA nephropathy (IgAN).The (NCT03762850) multicenter, international, randomized, double-blind, parallel-group, active-controlled study. efficacy safety of versus the active control irbesartan being evaluated biopsy-proven IgAN proteinuria ≥1.0 g/d despite maximized...
Abstract Background Cystic fibrosis is a chronic, life‐threatening illness. Coping, vicarious hope and despair are constructs that may explain why some children parents adjust well to cystic fibrosis, while others poorly. Vicarious refers parent expectations desirable things will occur in their child's future, whereas undesirable future. The aims of this study were: (1) examine coping strategies associations with child adjustment fibrosis; (2) investigate the effects on coping, adjustment;...
<b><i>Background:</i></b> A new class of dialysis membrane, the mid cut-off (MCO) dialyzer, has been developed to improve clearance uremic toxins in hemodialysis (HD). The a tRial Evaluating Mid cut-Off Value membrane Albumin and Light chains HemoDialysis patients (REMOVAL-HD) study aimed determine if regular use MCO dialyzer was safe specifically did not result significant loss albumin. <b><i>Methods:</i></b> This investigator initiated,...
Abstract Background Several clinical trials have shown beneficial effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors on kidney disease progression and cardiovascular morbidity mortality in patients with chronic (CKD) without type diabetes mellitus. However, some subgroups CKD been excluded from participation these trials, such as severely impaired function, dialysis, transplant recipients. Methods The Renal Lifecycle trial (NCT05374291) is a pragmatic, international, multicenter,...