A5005179367- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- Organ Donation and Transplantation
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Pregnancy-related medical research
- Bone health and osteoporosis research
- Pregnancy and Medication Impact
- Bone health and treatments
- Chronic Kidney Disease and Diabetes
- Polyomavirus and related diseases
- Organ Transplantation Techniques and Outcomes
- Clinical Nutrition and Gastroenterology
- Complement system in diseases
- Acute Kidney Injury Research
- Viral-associated cancers and disorders
- Central Venous Catheters and Hemodialysis
- Transplantation: Methods and Outcomes
- Neurological Complications and Syndromes
- Pelvic and Acetabular Injuries
- Bone and Joint Diseases
- Endometriosis Research and Treatment
- Palliative Care and End-of-Life Issues
- Nutrition and Health in Aging
The Royal Melbourne Hospital
2012-2025
The University of Melbourne
2005-2025
Monash University
2023
The University of Sydney
2012-2023
Monash Health
2023
Agriculture Victoria Services (Australia)
2023
Taranaki Base Hospital
2023
Cappagh National Orthopaedic Hospital
2006-2022
The Alfred Hospital
2018
In-Q-Tel
2014
The effect of glucocorticoids on major kidney outcomes and adverse events in IgA nephropathy has been uncertain.To evaluate the efficacy effects methylprednisolone patients with at high risk function decline.An international, multicenter, double-blind, randomized clinical trial that enrolled 503 participants nephropathy, proteinuria greater than or equal to 1 g per day, estimated glomerular filtration rate (eGFR) 20 120 mL/min/1.73 m2 after least 3 months optimized background care from 67...
<h3>Background:</h3> For every patient with chronic kidney disease who undergoes renal-replacement therapy, there is one conservative management of their disease. We aimed to determine the most important characteristics dialysis and trade-offs patients were willing make in choosing instead care. <h3>Methods:</h3> conducted a discrete choice experiment involving adults stage 3–5 from eight renal clinics Australia. assessed influence treatment (life expectancy, number visits hospital per week,...
ABO incompatible living donor renal transplantation (ABOi) can achieve outcomes comparable to compatible (ABOc). However, with the exception of blood group A2 kidneys transplanted into recipients low titer anti-A antibody, regimens generally include antibody removal, intensified immunosuppression and splenectomy or rituximab. We now report a series 20 successful transplants across range incompatibilities using conventional alone in baseline anti-blood (ABGAb) titers. Incompatibilities were...
Renal fibroblasts are important effector cells in tubulointerstitial fibrosis, with experimental antifibrotic strategies focusing on the functional down-regulation of these cells. Several models fibrosis have provided evidence for effectiveness polypeptide hormone relaxin as a potential agent. This study was conducted to further elucidate mechanisms renal vitro.Rat cortical were obtained from outgrowth culture tissue isolated kidneys 3 days post-unilateral ureteric obstruction and...
The latest Caring for Australians with Renal Impairment (CARI) guideline detailing renal transplant care, developed as a local modification of the Kidney Disease Improving Global Outcomes (KDIGO) guidelines.
<b><i>Background:</i></b> Cortical bone is a significant determinant of strength and its deterioration contributes to fragility. Thin cortices increased cortical porosity have been noted in patients with chronic kidney disease (CKD), but the “Turnover Mineralization Volume” classification renal osteodystrophy does not emphasize as key parameter. We aimed assess trabecular microarchitecture by histomorphometry micro-CT CKD G5 5D (dialysis)....
Abstract Background Several clinical trials have shown beneficial effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors on kidney disease progression and cardiovascular morbidity mortality in patients with chronic (CKD) without type diabetes mellitus. However, some subgroups CKD been excluded from participation these trials, such as severely impaired function, dialysis, transplant recipients. Methods The Renal Lifecycle trial (NCT05374291) is a pragmatic, international, multicenter,...
Please cite this paper as: Baweja S, Kent A, Masterson R, Roberts McMahon L. Prediction of pre-eclampsia in early pregnancy by estimating the spot urinary albumin: creatinine ratio using high-performance liquid chromatography. BJOG 2011;118:1126–1132. Objective To establish whether a (ACR) measured before 20 weeks gestation can predict subsequent when albumin is chromatography (HPLC). Design Prospective exploratory study. Setting Antenatal clinic tertiary teaching hospital, Victoria,...
Relaxin is a naturally occurring regulator of collagen turnover. In this study, we determined the role endogenous relaxin in pathogenesis primary tubulointerstitial fibrosis after unilateral ureteric obstruction (UUO). Four- to 6-wk-old (RLX) gene-knockout (RLX(-/-)) and age-matched wild-type (RLX(+/+)) mice, with equivalent baseline levels, were subjected UUO. Obstructed contralateral kidneys collected at d 0, 3, 10 surgery analyzed for changes inflammatory fibrosis-related markers. UUO was...
Background. Statins are antilipidemic agents that exhibit a variety of cellular effects independent their lipid-lowering action. A retrospective study was undertaken to establish the impact statins on graft outcome in first year posttransplantation. Methods. Data from patients with uniform immunosuppression (cyclosporine, mycophenolate mofetil, and prednisolone) who underwent transplantation at authors' unit 1997 2002 were reviewed. Patients prescribed compared those not statin. Mean change...
The management of chronic kidney disease is complex. With being the responsibility parents in paediatric renal clinic, gradually shifted to adolescents and young adults during transition adult care. This multi-perspective qualitative study aimed explore experiences adults, their health professionals gain an insight into transitional Focussing on process transfer care, 18 eight mothers participated individual semi-structured interviews. Additionally, three focus groups were conducted with 20...
Excellent short-term results have been reported in ABO-incompatible (ABOi) renal transplant recipients managed solely with antibody removal and conventional immunosuppression. However, long-term clinical outcomes this regimen predictive information from protocol biopsies are lacking.We compared outcome data ABOi ABO-compatible (ABOc) receiving approximately 4 years posttransplant, histology 12 months posttransplant.Patient graft survivals among 54 were 98.1% 90.7%, respectively, at years....
Choice of immunosuppression may modify the risk cancer after kidney transplantation, however, long-term data are lacking. Using Australian and New Zealand Dialysis Transplant Registry, we compared 9-year incident cancer, non-melanoma skin (NMSC), death attributed to among participants from Australia in four randomized-controlled trials which de novo or early switch an everolimus-containing regimen with calcineurin-inhibitor-based triple therapy. An adjusted Cox-model random effects was used...
New onset diabetes after transplantation (NODAT) is a common adverse outcome of organ that increases the risk cardiovascular disease, infection and graft rejection. In kidney transplantation, apart from traditional factors, autosomal dominant polycystic disease (ADPKD) has also been reported by several authors as predisposing factor to development NODAT, but any rationale for an association between ADPKD NODAT unclear. We examined cumulative incidence in or own transplant population...
Cinacalcet is effective in reducing parathyroid hormone (PTH) patients on dialysis. Reports of biochemical profiles and other clinical outcomes discontinuing cinacalcet at time renal transplantation are limited.A retrospective study assessing markers mineral metabolism, graft patient transplant recipients to determine differences (C+) compared with not treated (C-) transplantation. To allow for between groups pre-transplant parameters, we also analysed a matched cohort C- C+ (2:1), age,...