A5044818896- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Microbial Community Ecology and Physiology
- Renal Diseases and Glomerulopathies
- Mediterranean and Iberian flora and fauna
- Urinary and Genital Oncology Studies
- Bladder and Urothelial Cancer Treatments
- Genomics and Phylogenetic Studies
- Metastasis and carcinoma case studies
- Immune Cell Function and Interaction
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Pineapple and bromelain studies
- Polar Research and Ecology
- Medical Imaging and Pathology Studies
- Circadian rhythm and melatonin
- Hepatocellular Carcinoma Treatment and Prognosis
- Mycorrhizal Fungi and Plant Interactions
- Kidney Stones and Urolithiasis Treatments
- Management of metastatic bone disease
- Horticultural and Viticultural Research
- Zoonotic diseases and public health
- Ovarian cancer diagnosis and treatment
- Immunotherapy and Immune Responses
University of Messina
1966-2024
Agostino Gemelli University Polyclinic
2021-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2024
Ospedale di Rivoli
2023
Università Cattolica del Sacro Cuore
2012-2023
Società Italiana di Nefrologia
2023
Azienda Sanitaria Locale di Asti
2023
Ospedale Policlinico San Martino
2023
Istituti Ospitalieri di Cremona
2022
Vall d'Hebron Institut de Recerca
2022
BackgroundAngiosarcoma is a highly aggressive soft tissue sarcoma. Responses to anthracyclines plus/minus ifosfamide, and taxanes alone or in combination with gemcitabine are well documented. Very few data available on as single agent.Patients methodsWe retrospectively reviewed all cases of advanced progressive angiosarcoma treated agent (1000 mg/m2 i.v. every week for 3 weeks 4 weeks), at Istituto Nazionale Tumori within the Italian Rare Cancers Network from January 2008 November...
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The novel multi-million read generating sequencing technologies are very promising for resolving the immense soil 16S rRNA gene bacterial diversity. Yet they have a limited maximum sequence length screening ability, restricting studies in DNA stretches of single hypervariable (V) regions. aim present study was to assess effects properties four consecutive V regions (V3-6) on commonly applied analytical methodologies ecology studies. Using an silico approach, performance each region compared...
Background: Circadian and sleep disturbances are associated with increased risk of mild cognitive impairment (MCI) Alzheimer’s disease (AD). Wearable activity trackers could provide a new approach in diagnosis prevention. Objective: To evaluate circadian rhythm parameters, through wearable trackers, MCI AD patients as compared to controls, focusing on sex dissimilarities. Methods: Based minute level data from consumer devices, we analyzed actigraphic parameters by applying an electromedical...
Background. Based on the excellent results with combination chemotherapy such as M-VAC (methotrexate, vinblastine, doxorubicin, and cisplatin) in patients advanced disease, neoadjuvant has been advocated to improve survival some cases permit bladder conservation. Methods. A Phase II study of was performed T2-T4N0M0 tumors. After clinical staging, three cycles were given. underwent postchemotherapy restaging, pathologic restaging (partial or radical cystectomy) planned. Results. Forty-six are...
The Po river plain lowland springs represent unique paradigms of managed environments. Their current locations used to be swamps that were drained 6-7 centuries ago, and they have been in constant use ever since. Our aims identify the effects land on microbial communities these soils, look for associated diversity drivers, assess applicability ecology theories with respect identified patterns. We screened across a transect via high-throughput sequencing partial 16S rrRNA gene amplicons. Land...
Many physiological processes in the human body follow a 24-h circadian rhythm controlled by clock system. Light, sensed retina, is predominant "zeitgeber" able to synchronize rhythms light-dark cycles. Circadian dysfunction and sleep disorders have been associated with aging neurodegenerative diseases including mild cognitive impairment (MCI) Alzheimer's disease (AD). In present study, we aimed at investigating genetic variability of genes AD patients compared healthy controls from Italy. We...
This phase II study was designed to evaluate the activity and safety of a combination epirubicin, oxaliplatin docetaxel in metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma. Forty patients with measurable distant metastases received epirubicin 50 mg/m2, 60 mg/m2 followed by 100 on day 1 each 21-day cycle. Primary end point response rates (RR). All were evaluable. The overall RR 47.5% (95% confidence interval (CI) 32–63). disease control 80%. Median time for 6 weeks....
Currently, no clearly superior management strategy exists for recurrent, platinum-resistant ovarian cancer. We tested the efficacy and safety of gemcitabine combined with oxaliplatin (GEMOX) in a multicentre phase II clinical trial. Forty one patients cancer were enrolled. Prior to study entry, all participants had received at least platinum-based regimen. Gemcitabine was administered 1000 mg/m2 as protracted infusion (100 min) on day 1, dose 100 2 hour infusion. Cycles repeated every two...
Abstract In this study, we report a novel connexin 32 ( CX32 ) mutation associated with cognitive impairment and differential degree of peripheral nerve involvement. We present clinical, electrophysiological, neuroimaging data on family X‐linked Charcot‐Marie‐Tooth disease caused by 41A >G the gap junction protein beta 1 GJB1 gene. The proband her sister presented severe neuropathy subclinical impairment; proband's brother showed mild neuropathy. This confirms that type X is clinically...
This phase II study was designed to evaluate the activity and safety of a combination irinotecan, docetaxel oxaliplatin in metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma. Forty patients with measurable distant metastasis received irinotecan 150 mg m−2 60 on day 1, 85 2. Cycles were repeated every 3 weeks. The primary end point demonstrate 50% improvement time-to-progression (TTP) over historical controls. All evaluable. Median TTP 6.5 months (95% confidence interval...