A5065063119- Food Allergy and Anaphylaxis Research
- Ovarian cancer diagnosis and treatment
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Eosinophilic Esophagitis
- Respiratory and Cough-Related Research
- Viral gastroenteritis research and epidemiology
- Epigenetics and DNA Methylation
- Advanced Biosensing Techniques and Applications
- Cancer Genomics and Diagnostics
- Respiratory viral infections research
- IL-33, ST2, and ILC Pathways
- Enterobacteriaceae and Cronobacter Research
- Transgenic Plants and Applications
- Genetically Modified Organisms Research
- Gene expression and cancer classification
- Chromatin Remodeling and Cancer
- Congenital Diaphragmatic Hernia Studies
- Renal Diseases and Glomerulopathies
- Infant Health and Development
- Chronic Kidney Disease and Diabetes
- Platelet Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Biomedical Ethics and Regulation
- Celiac Disease Research and Management
Murdoch Children's Research Institute
2014-2025
The University of Melbourne
2016-2024
Royal Children's Hospital
2015-2024
Monash Children’s Hospital
2024
Duke University
2024
Clinical Research Institute
2024
University of Chicago
2021-2023
University of Kentucky
2021
Hudson Institute of Medical Research
2016-2018
Max Delbrück Center
2018
Folate intake during pregnancy may affect the regulation of DNA methylation fetal development. The genomic regions in offspring that be sensitive to folate exposure utero development have not been characterized. Using genome-scale profiling, we investigated 2 immune cell types (CD4+ and antigen-presenting cells) isolated from neonatal cord blood, selected on basis exposure. High-folate (HF; n=11) low-folate (LF; n=12) groups were opposite extremes maternal serum levels measured last...
Abstract Background A defective skin barrier is hypothesized to be an important route of sensitization dietary antigens and may lead food allergy in some children. Missense mutations the serine peptidase inhibitor Kazal type 5 ( SPINK ) gene have previously been associated with allergic conditions. Objective To determine whether genetic variants around are IgE‐mediated allergy. Method We genotyped 71 “tag” single nucleotide polymorphisms (tag‐ SNP s) within a region spanning ~263 kb...
Genetic variants for IgE-mediated peanut allergy are yet to be fully characterized and date only one genomewide association study (GWAS) has been published.To identify genetic associated with challenge-proven allergy.We carried out a GWAS comparing 73 infants against 148 non-allergic (all ~ 1 year old). We tested total of 3.8 million single nucleotide polymorphisms, as well imputed HLA alleles amino acids. Replication was assessed by de novo genotyping in panel additional 117 cases 380...
The growing use of neoadjuvant chemotherapy to treat advanced stage high-grade serous ovarian cancer (HGSOC) creates an opportunity better understand chemotherapy-induced mutational and gene expression changes. Here we performed a cohort study including 34 patients with IIIC or IV HGSOC assess changes in the tumor genome transcriptome women receiving chemotherapy. RNA sequencing panel DNA 596 cancer-related genes was on paired formalin-fixed paraffin-embedded specimens collected before after...
Introduction: Chronic inflammatory diseases including allergies and asthma are the result of complex interactions between genes environmental factors. Epigenetic mechanisms comprise a set biochemical reactions that regulate gene expression. In order to understand cause-effect relationship exposures disease development, methods capable assessing epigenetic regulation (also) in large cohorts needed. Methods: For this purpose, we developed evaluated miniaturized chromatin immunoprecipitation...
Food allergies pose a considerable world-wide public health burden with incidence as high one in ten 12-month-old infants. Few food allergy genetic risk variants have yet been identified. The Th2 immune gene IL13 is highly plausible candidate it central to the initiation of IgE class switching B cells.Here, we sought investigate whether polymorphisms at are associated development challenge-proven IgE-mediated allergy.We genotyped nine "tag" single nucleotide (tag SNPs) 367 allergic cases,...
The immunological changes underpinning acquisition of remission (also called sustained unresponsiveness) following food immunotherapy remain poorly defined. Limited access to effective therapies and biosamples from treatment responders has prevented progress. Probiotic peanut oral is highly at inducing remission, providing an opportunity investigate immune changes.Using a systems biology approach, we examined gene co-expression network patterns in peanut-specific CD4+ T cell responses before...
Preterm infants are more likely to experience severe respiratory syncytial virus (RSV) disease compared term infants. The reasons for this multi-factorial, however their immature immune system is believed be a major contributing factor.
Abstract This review summarizes recent advances in characterizing the transcriptional pathways associated with outcomes following Oral Immunotherapy. Recent technological including single‐cell sequencing are transforming ways which landscape is understood. The application of these technologies still its infancy food allergy but here we summarize current understanding gene expression changes oral immunotherapy for and specific signatures underpinning different clinical desensitization...
Few studies have examined long-term outcomes following oral immunotherapy (OIT); none risks and benefits associated with distinct clinical (desensitization, remission).
Remission is the desired outcome following OIT as it allows individuals to discontinue treatment and eat allergen freely. Early initiation of in infants toddlers has been embraced an approach increase likelihood remission. However, there no high-quality evidence supporting younger age independent factor driving remission; available studies are limited by small samples subjects lack adjustment for confounding covariates, particularly peanut-specific IgE (sIgE) levels which closely correlated with age.
Probiotic and Peanut Oral Immunotherapy (PPOIT) is effective at inducing sustained unresponsiveness (SU) end-of-treatment this effect persists up to four years post-treatment, referred as persistent SU. We sought evaluate (i) how PPOIT altered peanut-specific humoral immune indices, (ii) such longitudinal indices relate
Abstract Higher prevalence of multiple sclerosis at higher latitudes is associated with reduced sunlight during childhood. Alterations in inflammatory Th17 and regulatory T cells (Treg) are autoimmunity. In Hobart, Australia (latitude 42.8° south), thirteen girls (aged 12–13) sixteen women had blood collected the evening daylight February/March, (post 15 h daylight) same time dark August/September 9 daylight). Height weight were measured. Participants completed online surveys prior around...
Remission is the desired outcome following OIT as it allows individuals to discontinue treatment and eat allergen freely. Early initiation of in infants toddlers has been embraced an approach increase likelihood remission. However, there no high-quality evidence supporting younger age independent factor driving remission; available studies are limited by small samples subjects lack adjustment for confounding covariates, particularly peanut-specific IgE (sIgE) levels which closely correlated...