A5050048653- Dialysis and Renal Disease Management
- Electrochemical sensors and biosensors
- Acute Kidney Injury Research
- Neurological and metabolic disorders
- Central Venous Catheters and Hemodialysis
- Renal Diseases and Glomerulopathies
- Diabetic Foot Ulcer Assessment and Management
- Renal function and acid-base balance
- Parathyroid Disorders and Treatments
- Kidney Stones and Urolithiasis Treatments
- Sensor Technology and Measurement Systems
- Erythropoietin and Anemia Treatment
- Spectroscopy Techniques in Biomedical and Chemical Research
- Muscle and Compartmental Disorders
- Microfluidic and Capillary Electrophoresis Applications
- Potassium and Related Disorders
- Analytical Chemistry and Sensors
- Advanced Glycation End Products research
- Methemoglobinemia and Tumor Lysis Syndrome
- Chronic Kidney Disease and Diabetes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Platelet Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Poisoning and overdose treatments
- Bipolar Disorder and Treatment
North Estonia Medical Centre
2019-2025
Tallinn University of Technology
2025
Tryptophan is an essential dietary amino acid that originates uremic toxins contribute to end-stage kidney disease (ESKD) patient outcomes. We evaluated serum levels and removal during haemodialysis haemodiafiltration of tryptophan tryptophan-derived toxins, indoxyl sulfate (IS) indole acetic (IAA), in ESKD patients different dialysis treatment settings. This prospective multicentre study four European centres enrolled 78 with ESKD. Blood spent dialysate samples obtained were analysed...
Optical monitoring of spent dialysate has been used to estimate the removal water-soluble low molecular weight as well protein-bound uremic toxins from blood end stage kidney disease (ESKD) patients. The aim this work was develop an optical method β2-microglobulin (β2M), a marker middle molecule (MM) toxins, during hemodialysis (HD) treatment. Ultraviolet (UV) and fluorescence spectra samples were recorded 88 dialysis sessions 22 ESKD patients, receiving four different settings treatments....
Optical online methods are used to monitor the haemodialysis treatment efficiency of end stage kidney disease (ESKD) patients. The aim this study was analyse effect administration UV-absorbing drugs, such as paracetamol (Par), on accuracy optical monitoring removal uremic toxins uric acid (UA) and indoxyl sulfate (IS) during standard (HD) haemodiafiltration (HDF) treatments. Nine patients received Par in daily dosages 1–4 g for 30 sessions. For 137 sessions, 36 total dosage drugs less than...
Abstract Background and Aims Several factors are known to influence the morbidity mortality of ESKD patients, among them cardiovascular disease, nutritional status, delivered dialysis dose, uremic toxins levels, infectious diseases. This observational study aimed analyse that impact survival patients on haemodialysis. Method We analysed 3- 5-year 76 during period 2018-2023 (17 females, 59 males, aged 63.6 ± 15.9 years) from four separate centres countries with diverse life expectancies,...
Abstract Background and Aims Kt/V urea is conventionally used hemodialysis (HD) adequacy marker, whereas many other uremic toxins with differing removal kinetics affect the mortality of end stage kidney disease (ESKD) patients. Among them, uric acid (UA) has been shown to cause cardiovascular ESKD Recently, determination UA concentration in blood optical sensors during HD attempted by Lin et al 2021 Żyłka 2023, but accuracy relatively low. Moreover, measured light absorption spent dialysate...
Patients with chronic kidney disease (CKD) are at higher cardiovascular risk than the general population. Cardiovascular diseases, vascular calcification among them, leading cause of death in these patients. Factors influencing oxidative stress, inflammation, and accumulation uremic toxins during CKD. Uric acid is a cardiorenal toxin that accumulates case malfunction. The primary therapy for replacing function removing from end-stage renal patients hemodialysis. Effective removal can be...
Abstract Background and Aims Urea is the most commonly exploited marker of dialysis adequacy. Plenty other uremic retention solutes with a deleterious effect on morbidity mortality patients accumulate in ESKD [1]. Commonly, are divided into three physicochemical types [2] representative markers urea, uric acid (UA),indoxyl sulfate (IS), β2-Microglobulin (B2M). Optical monitoring molecules has been proposed [3]. Despite being cumbersome as clinical routine, direct quantification from total...
Protein-bound uremic toxins (PBUT), linked with the progression of renal disease and cardiovascular disease, accumulate in ESKD patients. Several recent studies have attempted to use albumin binding competitors or displacers for enhanced PBUT elimination. However, careful monitoring administrating is needed avoid adverse clinical effects Some potential (e.g. Furosemide) absorb UV-light, offering an opportunity monitor chemical displacer treatment optically.
Kt/Vurea is the most used marker to estimate dialysis adequacy; however, it does not reflect removal of many other uraemic toxins, and a new approach needed. We have assessed feasibility estimating intradialytic serum time-averaged concentration (TAC) various toxins from their spent dialysate concentrations that can be estimated non-invasively online with optical methods. Serum levels total removed solute (TRS) urea, uric acid (UA), indoxyl sulphate (IS) β2-microglobulin (β2M) were evaluated...
Abstract Background and Aims Hemodialysis (HD) adequacy is generally estimated by the dialysis marker Kt/V urea that poorly describes removal of uremic toxins with different kinetics, such as protein bound or middle molecule toxins, which have direct effect on morbidity mortality end stage kidney disease (ESKD) patients. We recently shown feasibility estimating an alternative can be applied to sessions varying settings intradialytic time average concentration (TAC) urea, uric acid (UA),...
Protein-bound uremic toxins (PBUT) are associated with high cardiovascular risk in patients chronic kidney disease, but according to known data, they not efficiently removed by the commonly used hemodialysis modalities (HD/HDF). Tao et al have studied effect of ibuprofen and furosemide as binding competitors on removal PBUT ex vivo model, no earlier studies been done. The aim this study was investigate combined aforementioned chemical displacers hemodialysis.
Abstract Background and Aims Indoxyl sulfate (IS) is a representative of the protein-bound uremic retention solutes [1]. Among CKD patients, high serum levels IS are associated with cardiovascular all-cause mortality – linked to outcomes, induces acceleration atherosclerosis abnormal bone metabolism [2,3]. Optical monitoring marker molecules in spent dialysate has been proposed [4] estimate on-line concentration removal toxins, allowing assess total removed solute rate toxins. Although...