A5079455479- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- COVID-19 Clinical Research Studies
- Muscle and Compartmental Disorders
- Central Venous Catheters and Hemodialysis
- Magnesium in Health and Disease
- Vitamin D Research Studies
- Effects and risks of endocrine disrupting chemicals
- Nutrition and Health in Aging
- SARS-CoV-2 and COVID-19 Research
- Psoriasis: Treatment and Pathogenesis
- Carcinogens and Genotoxicity Assessment
- Pharmacological Effects and Toxicity Studies
- Potassium and Related Disorders
- Alkaline Phosphatase Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Hepatitis C virus research
- COVID-19 and healthcare impacts
- Frailty in Older Adults
- Long-Term Effects of COVID-19
- Vitamin C and Antioxidants Research
- Neurological and metabolic disorders
- Diet and metabolism studies
- Lysosomal Storage Disorders Research
- Genetic Syndromes and Imprinting
Hospital Universitario Fundación Jiménez Díaz
2015-2024
Universidad Autónoma de Madrid
2015-2024
Hospital Universitario De Cabueñes
2023
Hospital Universitario Infanta Leonor
2022
Instituto de Investigación de Enfermedades Raras
2019-2020
Fundación Renal
2012-2020
Spanish Clinical Research Network
2017-2020
Federación Española de Enfermedades Raras
2020
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2015
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2015
Background. In chronic kidney disease (CKD) patients, the ability to excrete a phosphate load is impaired. Compensatory increase in parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) promote phosphaturia. Serum FGF23 concentration considered an early biomarker of excess high levels have been associated with increased mortality. present study, we evaluated changes plasma after treatment binder lanthanum carbonate patients CKD-3 normal serum concentration. Methods. Eighteen...
Complement dysregulation occurs in thrombotic microangiopathies (TMAs) other than primary atypical haemolytic uraemic syndrome (aHUS). A few of these patients have been reported previously to be successfully treated with eculizumab.We identified 29 so-called secondary aHUS who had received eculizumab at 11 Spanish nephrology centres. Primary outcome was TMA resolution, defined by a normalization platelet count (>150 × 10 9 /L) and haemoglobin, disappearance all the markers microangiopathic...
Occult hepatitis C virus (HCV) infection (i.e., detectable HCV-RNA in the liver or peripheral blood mononuclear cells) absence of both serum and anti-HCV antibodies has not been investigated hemodialysis patients. In this study, real-time PCR situ hybridization was used to test for presence genomic antigenomic cells 109 patients with abnormal levels enzymes. HCV infection, determined by HCV-RNA, found 45% patients; 53% these had ongoing replication, indicated HCV-RNA. Patients occult spent a...
Bisphenol A (BPA), a component of some dialysis membranes, accumulates in CKD. Observational studies have linked BPA exposure to kidney and cardiovascular injury humans, animal described causative link. Normal kidneys rapidly excrete BPA, but insufficient excretion may sensitize patients with CKD adverse the effects BPA. Using crossover design, we studied effect BPA-containing polysulfone or BPA-free polynephron dialyzers on levels 69 prevalent hemodialysis: 28 started were switched...
Chronic kidney disease (CKD) patients are at high-risk for severe coronavirus 2019 (COVID-19). The multicentric, observational and prospective SENCOVAC study aims to describe the humoral response safety of acute respiratory syndrome 2 (SARS-CoV-2) vaccines in CKD patients. Safety immediate results reported here.Four cohorts were included: transplant (KT) recipients, haemodialysis (HD), peritoneal dialysis (PD) non-dialysis from 50 Spanish centres. Adverse events after vaccine doses recorded....
Patients with renal impairment progressively lose the ability to excrete phosphorus. Decreased glomerular filtration of phosphorus is initially compensated by decreased tubular reabsorption, regulated PTH and FGF23, maintaining normal serum concentrations. There a close relationship between protein intake. In chronic disease, low dietary content slows progression kidney especially in patients proteinuria decreases supply phosphorus, which has been directly related disease patient survival....
Phenols are uremic toxins of intestinal origin formed by bacteria during protein metabolism. Of these molecules, p-cresol is the most studied and has been associated with renal function impairment vascular damage. Bisphenol A (BPA) a molecule structural similarity phenols found in plastic food beverage containers as well some dialyzers. BPA considered an environmental toxicant based on animal cell culture studies. Japanese authorities recently banned use baby bottles observational...
Uremic toxins that accumulate in chronic kidney disease (CKD) contribute to CKD complications, such as progression. Bisphenol A (BPA) is a ubiquitous environmental toxin, structurally related with p-cresol, accumulates CKD. Our aim was characterize the nephrotoxic potential of BPA. Specifically, we addressed BPA toxicity over energy-demanding proximal tubular cells.Cell death and oxidative stress were evaluated by flow cytometry confocal microscopy HK-2 human epithelial cells. Functional...
Dialysis confers the highest risk of coronavirus disease 2019 (COVID-19) death among comorbidities predisposing to severe COVID-19. However, reports COVID-19-associated mortality frequently refer during initial hospitalization or first month after diagnosis.
(1) Sarcopenia is a progressive loss of skeletal muscle mass and strength. The aim this study was to determine the association sarcopenia, defined according Working Group on in Older People (EWGSOP2) diagnostic criteria, with mortality at 24 months very elderly hemodialysis patients. (2) A prospective conducted 60 patients chronic who were older than 75 years. diagnosed EWGSOP2 criteria. Additionally, clinical, anthropometric analytical variables body composition by bioimpedance assessed....
ABSTRACT Background There is scarce evidence on the fourth dose of severe acute respiratory syndrome coronavirus 2 vaccines in chronic kidney disease (CKD) patients. We evaluated humoral response and effectivity CKD spectrum: non-dialysis (ND-CKD), haemodialysis (HD), peritoneal dialysis (PD) transplant (KT) recipients. Methods This a prespecified analysis prospective, observational, multicentric SENCOVAC study. In patients with who had received complete initial vaccination one or two...
Abstract Malnutrition is highly prevalent in dialysis patients and associated with poor outcomes. In 2008, protein–energy wasting (PEW) was coined by the International Society of Renal Nutrition Metabolism (ISRNM), as a single pathological condition which undernourishment hypercatabolism converge. 2014, new simplified score described using serum creatinine adjusted for body surface area (sCr/BSA) to replace reduction muscle mass over time category. We have now compared PEW–ISRNM 2008...