A5057034183- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Pregnancy and preeclampsia studies
- Chronic Kidney Disease and Diabetes
- Air Quality and Health Impacts
- Gestational Diabetes Research and Management
- Climate Change and Health Impacts
- Fatty Acid Research and Health
- Dialysis and Renal Disease Management
- Energy and Environment Impacts
- Spectroscopy Techniques in Biomedical and Chemical Research
- Renal and related cancers
- Microbial metabolism and enzyme function
- Epigenetics and DNA Methylation
- Renal Diseases and Glomerulopathies
- Ion Transport and Channel Regulation
- Smoking Behavior and Cessation
- Gut microbiota and health
- Diet and metabolism studies
- Pancreatic function and diabetes
- Optical Imaging and Spectroscopy Techniques
- Regulation of Appetite and Obesity
- Diet, Metabolism, and Disease
- Advanced Glycation End Products research
- Neonatal Respiratory Health Research
The University of Sydney
2016-2025
Royal North Shore Hospital
2016-2025
Keogh Institute for Medical Research
2023-2024
University of Technology Sydney
2015-2023
Hangzhou Normal University
2018-2020
North Shore Hospital
2004-2020
Shandong University
2019
Northern Sydney Local Health District
2013-2018
Westmead Hospital
2000-2004
Westmead Institute
2000-2004
Abstract Background Short-chain fatty acids (SCFAs) produced by the gut microbiota have beneficial anti-inflammatory and homeostasis effects prevent type 1 diabetes (T1D) in mice. Reduced SCFA production indicates a loss of bacteria, commonly associated with chronic autoimmune inflammatory diseases, including T1D 2 diabetes. Here, we addressed whether metabolite-based dietary supplement has an impact on humans T1D. We conducted single-arm pilot-and-feasibility trial high-amylose...
Objectives Gold nanoparticles (AuNPs) of 21 nm have been previously well characterized in vitro for their capacity to target macrophages via active uptake. However, the short-term impact such AuNPs on physiological systems, particular resident located fat tissue vivo, is largely unknown. This project investigated distribution, organ toxicity and changes inflammatory cytokines within adipose after mice were exposed AuNPs. Methods Male C57BL/6 injected intraperitoneally (IP) with a single dose...
Multiple rodent models have been used to study diabetic kidney disease (DKD). The purpose of the present was compare diabetes and obesity-induced metabolic syndrome determine differences in renal outcomes. C57BL/6 male mice were fed either normal chow or high fat diet (HFD). At postnatal week 8, chow-fed randomly assigned low-dose streptozotocin (STZ, 55 mg/kg/day, five consecutive days) vehicle control, whereas HFD-fed given one high-dose STZ (100 mg/kg) control. Intraperitoneal glucose...
Abstract Automated and unbiased methods of non-invasive cell monitoring able to deal with complex biological heterogeneity are fundamentally important for biology medicine. Label-free imaging provides information about endogenous autofluorescent metabolites, enzymes cofactors in cells. However extracting high content from autofluorescence has been hitherto impossible. Here, we quantitatively characterise populations different tissue types, live or fixed, by using novel image processing a...
Abstract Maternal cigarette smoke exposure (SE) during gestation can cause lifelong adverse effects in the offspring’s brain. Several factors may contribute including inflammation, oxidative stress and hypoxia, whose changes developing brain are unknown. Female Balb/c mice were exposed to prior mating, lactation. Male offspring studied at postnatal day (P) 1, P20 13 weeks (W13). SE dams had reduced inflammatory mediators (IL-1β, IL-6 toll like receptor (TLR)4 mRNA), antioxidant (manganese...
Air pollution is a ubiquitous problem and comprises gaseous particulate matter (PM). Epidemiological studies have clearly shown that exposure to PM associated with impaired lung function the development of diseases, such as chronic obstructive pulmonary disease asthma. To understand mechanisms involved, animal models are often used. However, majority represent high levels not representative in less polluted countries, Australia. Therefore, this study, we aimed determine whether low dose 10...
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists are increasingly used in patients with diabetes, and small studies have suggested a beneficial effect on renal function, but their effects extracellular matrix (ECM) turnover unknown. The aims of this study were to investigate the PPAR-gamma agonist pioglitazone growth production human cortical fibroblasts (CF). Cell ECM measured CF presence absence 1 3 muM pioglitazone. Exposure caused an antiproliferative (P < 0.0001)...
Cigarette smoking is an addictive behaviour, and the primary cause of cardiovascular pulmonary disease, cancer (among other diseases). smoke contains thousands components that may affect caloric intake energy expenditure, although nicotine major substance present, has best described actions. Nicotine exposure from cigarette can change brain feeding regulation to reduce appetite via both homeostatic reward mechanisms, causing a negative state which characterized by reduced increased...
Hyperglycemia induces all isoforms of transforming growth factor β (TGFβ), which in turn play key roles inflammation and fibrosis that characterize diabetic nephropathy. Sphingosine 1-phosphate (S1P) is a signaling sphingolipid, derived from sphingosine by the action kinase (SK). S1P mediates many biological processes, mimic TGFβ signaling. To determine role SK1 inducing inflammation, interaction with TGFβ-1, 2 3 signalling nephropathy, human proximal tubular cells (HK2 cells) were exposed...
Abstract Maternal obesity is associated with an increased risk of chronic disease in offspring, including type 2 diabetes (T2D). Exendin-4 (Exd-4) activates the glucagon like peptide-1 (GLP-1) receptor thereby decreasing serum glucose levels and body weight. In addition, Exd-4 has been shown to reduce renal cardiac complications experimental models T2D. We hypothesized that treatment would ameliorate detrimental effects maternal diet-induced on characteristics offspring. Female...
Abstract Maternal smoking during pregnancy is a significant risk factor of renal pathology in the offspring. E‐cigarettes are perceived to be safe option and increasingly used by pregnant women either continuously or as replacement for tobacco cigarettes. This study aimed determine effects replacing cigarettes with e‐cigarettes pregnancy, continuous e‐cigarette use on offspring's kidneys. Female Balb/c mice were exposed air (sham) cigarette smoke (SE) 6 weeks prior mating, gestation...
Air pollution is the 9th cause of overall disease burden globally. The solid component in polluted air, particulate matters (PMs) with a diameter 2.5 μm or smaller (PM2.5) possess significant health risk to several organ systems. PM2.5 has also been shown cross blood–placental barrier and circulate foetal blood. Therefore, it considered an intrauterine environmental toxin. Exposure during perinatal period, when foetus particularly susceptible developmental defects, reduce birth weight...
This study aimed to investigate whether maternal cigarette smoke exposure can disrupt fetal kidney development by changing the expression of growth and transcription factors essential for renal development, thereafter predispose offspring chronic disease later in life. Female Balb/c mice (6 weeks) were exposed either or air under identical conditions, 6 weeks prior mating, during gestation lactation. Male sacrificed at three time points, postnatal day (P)1, P20 (weaning age), 13 (mature...
Abstract To investigate the effect of maternal MitoQ treatment on renal disorders caused by cigarette smoke exposure (SE). We have demonstrated that SE during pregnancy increases risk developing chronic kidney disease (CKD) in adult offspring. Mitochondrial oxidative damage contributes to adverse effects smoking disorders. is a mitochondria-targeted antioxidant has been shown protect against damage-related pathologies many diseases. Female Balb/c mice (8 weeks) were divided into Sham...