Giorgia Comai
A5036731985- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Chronic Kidney Disease and Diabetes
- Transplantation: Methods and Outcomes
- Dialysis and Renal Disease Management
- Liver Disease and Transplantation
- Complement system in diseases
- COVID-19 Clinical Research Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Acute Kidney Injury Research
- Pregnancy and Medication Impact
- Neurological Complications and Syndromes
- Parathyroid Disorders and Treatments
- Cytomegalovirus and herpesvirus research
- Metabolism and Genetic Disorders
- Multiple Myeloma Research and Treatments
- Polyomavirus and related diseases
- SARS-CoV-2 and COVID-19 Research
- Atrial Fibrillation Management and Outcomes
- Renal cell carcinoma treatment
- Autoimmune Bullous Skin Diseases
- Parvovirus B19 Infection Studies
University of Bologna
2016-2025
Azienda USL di Bologna
2020-2025
Policlinico S.Orsola-Malpighi
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2024
Metabolism and Renal Physiology
2009-2022
March of Dimes
2017
Creative Research Enterprises (United States)
2015
Jichi Medical University
2012
Ravulizumab is a long-acting C5 inhibitor engineered from eculizumab with increased elimination half-life, allowing an extended dosing interval two to eight weeks. Here we evaluate the efficacy and safety of ravulizumab in adults atypical hemolytic uremic syndrome presenting thrombotic microangiopathy. In this global, phase 3, single arm study complement inhibitor-naïve (18 years older) who fulfilled diagnostic criteria for syndrome, enrolled patients received through 26-week initial...
Background and objectives FSGS recurrence after kidney transplantation is a major risk factor for graft loss. However, the natural history, clinical predictors, response to treatment remain unclear because of small sample sizes poor generalizability single-center studies, disease misclassification in registry-based studies. We therefore aimed determine incidence, recurrent large cohort transplant recipients. Design, setting, participants, & measurements The Post-Transplant Glomerular...
Restless legs syndrome (RLS) is a sensorimotor neurological disorder characterized by paraesthesia, dysaesthesia and the irresistible urge to move especially at night. Its prevalence much higher among dialysis patients 12 62% compared 3 9% in general population. Here, we investigated association between RLS cardiovascular events risk laboratory parameters end-stage kidney disease (ESKD) on dialysis.One hundred ESKD undergoing haemodialysis were enrolled an 18-month prospective observational...
Background and objectives In patients with kidney failure due to IgA nephropathy, deposits can recur in a subsequent transplant. The incidence, effect, risk factors of nephropathy recurrence is unclear, because most studies have been single center sample sizes are relatively small. Design, setting, participants, & measurements We performed multicenter, international, retrospective study determine the factors, treatment response recurrent after transplantation. Data were collected from...
IntroductionPost-transplant thrombotic microangiopathy (PT-TMA) is an uncommon event that characterizes approximately 3-14% of kidney transplants (KT), and associated with a higher risk delayed graft function loss. PT-TMA occurs more frequently within the first three months after transplant can be manifestation de novo disease or recurrence previous atypical hemolytic uremic syndrome (aHUS). Abnormalities in complement regulation genes could explain increased susceptibility some patients to...
Abstract With the aim to explore innovative tools for organ preservation, especially in marginal organs, we hereby describe a clinical trial of ex-vivo hypothermic oxygenated perfusion (HOPE) field liver (LT) and kidney transplantation (KT) from Extended Criteria Donors (ECD) after brain death. A matched-case analysis donor recipient variables was developed: 10 HOPE-ECD livers kidneys (HOPE-L HOPE-K) were matched 1:3 with preserved static cold storage (SCS-L SCS-K). HOPE SCS groups resulted...
Coronavirus disease 2019 (COVID-19) may be associated with worse outcome in solid organ transplant (SOT) recipients. We performed a prospective cohort study of hospitalized patients confirmed diagnosis COVID-19, from March 15 to April 30, 2020, at two tertiary hospitals Emilia-Romagna Region. SOT recipients were compared non-SOT patients. Primary endpoint was all-cause 30-day mortality. Relationship between status and mortality investigated by univariable multivariable Cox regression...
Italy was the first Western country to face COVID-19 pandemic. Here we report results of a national survey on kidney transplantation activity in February and March 2020, three-round Delphi consensus promoted by four scientific societies: Italian Society Organ Transplantation, Nephrology, Anesthesia Intensive Care, Group Antimicrobial Stewardship. All 41 transplant centers were invited express their opinion rounds along with group seven experts. The revealed that, starting from there decline...
Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in solid organ transplant (SOT) recipients is associated with poorer antibody response (AbR) compared non-SOT recipients. However, its impact on the risk of breakthrough infection (BI) has yet to be assessed. Methods Single-center prospective longitudinal cohort study enrolling adult SOT who received SARS-CoV-2 during a 1-year period (February 2021 – January 2022), end follow-up April 2022. Patients...
The effects of SARS-CoV-2 infection on individuals with immune-mediated glomerulonephritis, who are often undergoing immunosuppressive treatments, unknown. Therefore, we created the International Registry COVID in glomerulonephritis (IRoc-GN) and identified 40 patients COVID-19 followed centers North America Europe. Detailed information diagnosis, kidney parameters, baseline immunosuppression prior to were recorded, as well clinical presentation, laboratory values, treatment, complications,...
ABSTRACT Background A long-standing effort is dedicated towards the identification of biomarkers allowing prediction graft outcome after kidney transplant. Extracellular vesicles (EVs) circulating in body fluids represent an attractive candidate, as their cargo mirrors originating cell and its pathophysiological status. The aim study was to investigate EV surface antigens potential predictors renal Methods We characterized 37 by flow cytometry, serum urine EVs from 58 patients who were...
Recurrence of IgA nephropathy (IgAN) after kidney transplant (KT) appears associated with worse graft survival; thus, the identification risk factors is worthwhile to improve pre-transplant evaluation KT recipients and identify optimal treatment strategy. The aim this study was determine incidence, impact on renal function survival IgAN recurrence KT. We performed a retrospective including 110 patients biopsy-proven IgAN, who underwent at Policlinico di Sant'Orsola Hospital - University...
Previous studies assessing the antibody response (AbR) to mRNA COVID-19 vaccines in solid organ transplant (SOT) recipients are limited by short follow-up, hampering analysis of AbR kinetics. We present ORCHESTRA SOT cohort assessed for at first dose (t0), second (t1), and within 3 ± 1 month (t2) after dose. analyzed 1062 patients (kidney, 63.7%; liver, 17.4%; heart, 16.7%; lung, 2.5%) 5045 health care workers (HCWs). The rates SOTs HCWs were 52.3% 99.4%. levels significantly higher than (p...
Membranous nephropathy (MN) is a leading cause of kidney failure worldwide, and frequently recurs after transplant. Available data originated from small retrospective cohort studies or registry analyses. Therefore, uncertainties remain on risk factors for MN recurrence response to therapy. Within the Post-Transplant Glomerular Disease (TANGO) Consortium, we conducted multicenter study examining rate, factors, treatment. This screened 22,921 patients across three continents included 194 who...
Chronic oral anticoagulation is currently used to avoid thrombosis and the malfunction of tunneled cuffed catheters (TCCs) for hemodialysis (HD). The aim study was assess efficacy early warfarin administration, after TCC placement, in comparison its administration first or event TCC.One hundred forty-four chronic dialysis patients, who underwent placement between June 2001 2005, were randomized into two groups: 81 group A, started 12 hr (target international normalized ratio (INR) 1.8-2.5),...
Hemodialysis (HD) patients have a greatly increased risk of cardiovascular morbidity and mortality. For this reason, attempts are often made to normalize hyperhomocysteinemia. This randomized prospective study sought determine which factors predictors mortality whether high doses folates or 5-methyltetrahydrofolate (5-MTHF) could improve hyperhomocysteinemia survival in HD patients.341 were divided into two groups: group A was treated with 50 mg i.v. 5-MTHF, B 5 mg/day oral folic acid. Both...
<b><i>Background:</i></b> In the absence of a histological diagnosis, persistent albuminuria is globally accepted as main diagnostic criteria for diabetic kidney disease (DKD). <b><i>Methods:</i></b> present retrospective study, we evaluated data from an Italian cohort 42 deceased donors (mainly with type 2 diabetes). Using biopsies obtained at time donation to evaluate single or double allocation based on Karpinski score, determined prevalence...
Long-term outcomes in kidney transplantation (KT) have not significantly improved during the past twenty years. Despite being a leading cause of graft failure, glomerular disease (GD) recurrence remains poorly understood, due to heterogeneity pathogenesis and clinical presentation, reliance on histopathology confirm recurrence, low incidence individual GD subtypes. Large, international cohorts patients with are urgently needed better understand pathophysiology, predictors response therapy....
Abstract There is increasing proof that organ preservation by machine perfusion able to limit ischemia/reperfusion injury in kidney transplantation. This study was designed compare the efficiency hypothermic or cold storage an animal model of autotransplantation. Twelve pigs underwent left nephrectomy after warm ischemic time; organs were preserved ( n = 6) and then autotransplanted with immediate contralateral nephrectomy. The following parameters compared between two groups animals:...