A5019348440- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Pancreatic function and diabetes
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- Diabetes and associated disorders
- Diabetes Management and Research
- Metabolism and Genetic Disorders
- Neurological and metabolic disorders
- Diabetes Treatment and Management
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Organ and Tissue Transplantation Research
- Cytomegalovirus and herpesvirus research
- Metabolism, Diabetes, and Cancer
- Dialysis and Renal Disease Management
- Polyomavirus and related diseases
- Clinical Nutrition and Gastroenterology
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Retinal Diseases and Treatments
- Systemic Lupus Erythematosus Research
- Advanced MRI Techniques and Applications
- Diet and metabolism studies
IRCCS Ospedale San Raffaele
2004-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2003-2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2003-2024
Vita-Salute San Raffaele University
1991-2024
San Raffaele University of Rome
2001-2021
University of Milan
1991-2001
Hôpital Edouard Herriot
1991
University of Naples Federico II
1991
Fatebenefratelli Hospital
1978
The First World Consensus Conference on Pancreas Transplantation provided 49 jury deliberations regarding the impact of pancreas transplantation treatment diabetic patients, and 110 experts' recommendations for practice transplantation. main message from this consensus conference is that both simultaneous pancreas-kidney (SPK) alone can improve long-term patient survival, all types dramatically quality life recipients. may also course chronic complications diabetes, depending their severity....
Cardiovascular mortality and morbidity are major problems in type 1 diabetic patients with end-stage renal disease (ESRD). The aim of this study was to determine whether islet transplantation can improve cardiovascular function these patients.We assessed various markers cardiac at baseline 3 years later a population 42 ESRD who received kidney transplant. Seventeen then an transplant that had persistent as defined by long-term C-peptide secretion (kidney-islet group). Twenty-five did not...
Italy was the first Western country to face COVID-19 pandemic. Here we report results of a national survey on kidney transplantation activity in February and March 2020, three-round Delphi consensus promoted by four scientific societies: Italian Society Organ Transplantation, Nephrology, Anesthesia Intensive Care, Group Antimicrobial Stewardship. All 41 transplant centers were invited express their opinion rounds along with group seven experts. The revealed that, starting from there decline...
Background. Patients undergoing kidney transplantation demonstrate a higher risk of developing cancer as the result immunosuppressive treatment and concurrent infections. Methods. The incidence in cohort patients who underwent between 1990 2000, survived acute phase (10 days), was analyzed part North Italy Transplant program. Results. A total 3,521 during 10-year period 10 13 participating centers; length follow-up after transplant 67.7±36.0 months. During follow-up, 172 developed (39 with...
The Review of Diabetic Studies,2011,8,1,44-50.DOI:10.1900/RDS.2011.8.44Published:May 2011Type:Review ArticleAuthors:Paola Maffi, Marina Scavini, Carlo Socci, Lorenzo Piemonti, Rossana Caldara, Chiara Gremizzi, Raffaella Melzi, Rita Nano, Elena Orsenigo, Massimo Venturini, Staudacher, Alessandro Del Maschio, and Antonio Secchi Author(s) affiliations:Paola Diabetes Research Institute, San Raffaele Scientific Via Olgettina 60, 20132 Milano, Italy. Abstract:Background: Pancreas islet...
Asymptomatic bacteriuria is frequent in kidney transplant recipients (KTRs). However, there no consensus on diagnosis or management. We conducted a European survey to explore current practice related the and management of asymptomatic adult KTRs.A panel experts from Renal Association-European Dialysis Transplant Association/Developing Education Science Care for Transplantation States working group Study Group Infections Compromised Hosts Society Clinical Microbiology Infectious Diseases...
Pancreatogenic diabetes, a consequence of pancreatic tissue loss following pancreatectomy, poses significant challenge for patients undergoing surgery. Islet autotransplantation (IAT) offers promising approach to prevent or alleviate pancreatogenic but its application has been limited individuals with painful chronic pancreatitis.
Operational tolerance is an alternative to lifelong immunosuppression after transplantation. One strategy achieve by T regulatory cells. Safety and feasibility of a type 1 (Tr1)-cell-based therapy prevent graft versus host disease in patients with hematological malignancies has been already proven. We are now planning perform Tr1-cell-based kidney transplantation.Upon tailoring the lab-grade protocol on dialysis, aims current work were develop clinical-grade compatible generate...
The pathogenesis of brain disorders in type 1 diabetes (T1D) is multifactorial and involves the adverse effects chronic hyperglycemia recurrent hypoglycemia. Kidney-pancreas (KP), but not kidney alone (KD), transplantation associated with sustained normoglycemia, improvement quality life, reduction morbidity/mortality diabetic patients end-stage renal disease (ESRD).The aim our study was to evaluate magnetic resonance imaging nuclear spectroscopy ((1)H MRS) cerebral morphology metabolism 15...
Background. The risk of transmitting a hepatitis B virus (HBV) infection from donor kidneys with past HBV serological profile may be negligible. Data on transmission to kidney transplant recipients organs that were anti-HBc+/HBsAg- in Italy has not been previously reported. Anti-HBc testing cadaver organ donors mandatory since 2002, when anti-HBc determinations included the National Guidelines for evaluation. Therefore, prior date can identified retrospectively where stored serum is...
T regulatory type 1 (Tr1) cell-mediated induction of tolerance in preclinical models transplantation is remarkably effective. The clinical application such a therapy patients on dialysis undergoing kidney should take into account the possible alterations immune system observed these patients. Herein, we aimed at testing ability to generate donor-specific Tr1 cell-enriched lymphocytes from waiting list for transplantation.The were generated by coculturing interleukin-10-producing dendritic...
Abstract Hypothermic machine perfusion (HPM) grants a better postoperative outcome in transplantation of organs procured from extended criteria donors (ECDs) and after cardiac death (DCD). So far, the only available parameter for prediction concerning those is pretransplant biopsy score. The aim this study to evaluate whether renal resistance (RR) trend during HPM may be used as predictive marker post‐transplantation outcome. From December 2015 present, HMP has been systematically applied...
Sexual function is altered in patients with type 1 diabetes (T1D) and end-stage renal disease (ESRD), thus affecting quality of life. The present study aimed to analyze sexual T1D ESRD (T1D+ESRD) who received a simultaneous kidney-pancreas (KP) or kidney-alone (KD) transplantation.Ten KP, 10 KD, 9 T1D+ESRD 11 healthy control subjects were evaluated according the following parameters: (1) medical/sexual history physical examination; (2) International Index Erectile Function; (3) Beck's...
In this study we analyzed the role of CCL2, a member chemokine family, in early graft damage. Using simultaneous kidney-pancreas transplantation (SPK) as model, showed that brain death significantly increases circulating CCL2 levels humans. We found such situations, high donor (measured before organ recovery and at onset cold preservation) correlate with increased postreperfusion release by both recipient throughout week following (n = 28). retrospective 77 SPK recipients, significant...
Donation after circulatory death (DCD) allows expansion of the donor pool. We report on 11 years Italian experience by comparing outcome grafts from DCD and extracorporeal membrane oxygenation (ECMO) prior to donation (EPD), a new category. studied 58 kidney recipients or EPD collected donor/recipient clinical characteristics. Primary non function (PNF) delayed graft (DGF) rates, dialysis need, hospitalization duration, patient survival rates were compared. The estimated glomerular...
Background: Obesity may negatively impact clinical outcomes in kidney transplant (KT) recipients. Limited information is available on the prevalence of obesity this population, and lifestyle habits associated with obesity. Methods: we conducted an online, anonymous survey to assess proportion KT recipients obesity, adherence Mediterranean diet (i.e., a dietary regimen proven renal cardiovascular outcomes) using MEDI-Lite questionnaire, level physical activity International Physical Activity...