A5019823502- Kidney Stones and Urolithiasis Treatments
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Porphyrin Metabolism and Disorders
- Cytomegalovirus and herpesvirus research
- Receptor Mechanisms and Signaling
- Nitric Oxide and Endothelin Effects
- Hepatitis C virus research
- Organ Donation and Transplantation
- Diabetes Management and Education
- Phosphodiesterase function and regulation
- Cholinesterase and Neurodegenerative Diseases
- Neurological Complications and Syndromes
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Gout, Hyperuricemia, Uric Acid
- Bone health and treatments
- Polyomavirus and related diseases
- Pharmacological Effects and Toxicity Studies
- Viral-associated cancers and disorders
- Renal Diseases and Glomerulopathies
- Parathyroid Disorders and Treatments
- Chemical synthesis and alkaloids
- Liver Disease and Transplantation
- Neonatal Health and Biochemistry
University of Perugia
2023-2024
University of Padua
2008-2022
Sapienza University of Rome
2019-2022
Azienda Ospedaliera di Padova
1998-2016
Ospedale Cisanello
2009
Istituto Oncologico Veneto
2007
Santa Maria Nuova Hospital
2006
University of Milan
2005
Zambon (Italy)
1992-2002
Zambon (Netherlands)
2001-2002
Assessing cytomegalovirus (CMV)-specific cell-mediated immunity (CMI) represents an appealing strategy for identifying transplant recipients at risk of infection. In this study, we compared two gamma interferon-releasing assays (IGRAs), Quantiferon-CMV and CMV enzyme-linked immunosorbent spot (ELISPOT), to determine the ability each test predict protective CMV-specific T-cell responses. Two hundred twenty-one ELISPOT tests were conducted on 120 adult kidney (KTRs), including 100...
Abstract The aim of this study was to investigate the effects alendronate, calcitriol, and calcium in bone loss after kidney transplantation. We enrolled 40 patients (27 men 13 women, aged 44.2 ± 11.6 years) who had received renal allograft at least 6 months before (time since transplant, 61.2 44.6 months). At baseline, parathyroid hormone (PTH) elevated 53% Z scores for alkaline phosphatase (b-ALP) urinary type I collagen cross-linked N-telopeptide (u-NTX) were higher than expected (p...
We measured the rate of oxalate flux across red-cell membrane in steady state 114 patients with a history calcium kidney stones and 25 controls. Of patients, 98 had recurrent, "idiopathic" stones, 8 primary hyperparathyroidism, 7 renal or urinary tract malformations, 1 hyperoxaluria. Oxalate exchange was significantly higher idiopathic stone formation than controls (-1.10 +/- 0.95 [SD] X 10(-2) min-1 vs. -0.31 0.12 10(-2); P less 0.001); it above upper limits normal 78 these patients. All...
Background. Patients undergoing kidney transplantation demonstrate a higher risk of developing cancer as the result immunosuppressive treatment and concurrent infections. Methods. The incidence in cohort patients who underwent between 1990 2000, survived acute phase (10 days), was analyzed part North Italy Transplant program. Results. A total 3,521 during 10-year period 10 13 participating centers; length follow-up after transplant 67.7±36.0 months. During follow-up, 172 developed (39 with...
Background: non-thyroidal illness syndrome (NTIS) has been associated with an adverse clinical outcome. Objective: to evaluate the prevalence of NTIS, its impact on patients' survival and possible pathogenic role systemic inflammation. Design: observational cross-sectional analysis. Participants setting: three hundred one acutely ill older patients (156 women; median age 81 years, range 65–101) consecutively admitted a primary care unit. Methods: serum FT3, FT4 thyrotropin levels as well...
Bone morbidity remains a major problem even after successful renal transplantation. We investigated the role of calcium-sensing receptor (CaSR) polymorphisms and 25-hydroxyvitamin D levels on persistence secondary hyperparathyroidism (SHPT) their relationships with vertebral fractures (VFx) in 125 allograft recipients transplanted 44 +/- 23 months before. All patients underwent evaluation main biochemical parameters calcium metabolism as well femoral bone density. In 87 patients, CaSR...
Background. In Fabry disease, end-stage renal disease (ESRD) and severe neurologic cardiac complications represent the leading causes of late morbidity mortality. A comprehensive Italian nationwide survey study was conducted to explore changes in status allograft function patients on replacement therapy (RRT) enzyme (ERT). Methods. This designed as a cross-sectional with prospective follow-up. Of 34 identified via searches registries, 31 males 2 females who received RRT ERT (agalsidase beta...
The aim of the present study is to investigate role emotional variables in diabetes adaptation. This order develop and test a conceptual model simultaneously involving consistent with framework looking at chronic illness as loss good self. A convenience sample 59 participants diagnosis type 1 (n= 26) 2 (n=33) mellitus (Mean age= 57.17, SD=16.82) completed measures distress, psychological adjustment diabetes, self-care (as outcomes adaptation) depression, alexithymia damaged ego-related...
Anomalies in the erythrocyte transport of anions and cations have been described idiopathic calcium oxalate nephrolithiasis seem to play a pathogenetic role this disease. In consideration hypothesis that complex array ion flux cell abnormalities is an epiphenomenon anomaly composition membranes, study investigated cell-membrane lipid composition. renal stone formers, which were present, healthy control subjects, plasma membrane composition, exchange, Na/K/2Cl cotransport activity evaluated....
The problem of infertility and its consequent treatment (denoted as Assisted Reproductive Technology or ART) represent an increasing phenomenon, especially in industrialized countries. Confronting with one’s own procreative limitations can generate strong negative emotional reactions. This study aims at understanding how the desire for motherhood manifests itself infertile women undergoing ART, studying their subjective perspective. An in-depth explorative research was conducted on 17...
Background. The Perforin-Granzyme B and Fas/Fas Ligand apoptotic mechanisms are involved in the development of acute renal rejection (AR). We describe our experience analyzing expression cytotoxic T-lymphotoxins (CTL) biopsies peripheral blood leukocytes (PBL) for diagnosis AR. Methods. analyzed Perforin (P), Granzyme (GB) Fas (FL) 68 64 PBL using comparative kinetic RT-PCR and, GAPDH FL, we also replicated with real-time RT-PCR. levels were measured different groups, such as T0 (biopsies...
Abstract Aim Recently, the relationship between diabetes and mental health has been widely studied. With advent of continuous glucose monitoring (CGM), some researchers have interested in exploring association glucose-related metrics psychological aspects. These studies primarily relied on self-report questionnaires which present limitations. Therefore, multicenter study aims at testing potential associations CGM affective processes derived from narratives about using a sensor. Methods An...
Kidneys from expanded-criteria donors may be particularly susceptible to calcineurin inhibitor (CI)-mediated vasoconstriction and nephrotoxicity. In the early post-transplant phase, using CI prolong ischemic injury and, in long term, chronic nephrotoxicity is an even greater concern. To avoid acute consequences of kidneys marginal donors, CI-free protocols have been introduced for maintenance immunosuppressive therapy. A protocol anti-thymocyte globulin (ATG) induction, sirolimus,...
Background. Long-term steroid immunosuppression has been associated with the prothrombotic state observed in renal transplant (RT) patients, whom both hypercoagulability due to an increase of von Willebrand factor/factor VIII complex, and impaired fibrinolysis PAI-1 excess have demonstrated.Our aim was investigate effect withdrawal on fibrinolytic capacity a group RT patients. Methods. The study performed 28 patients under stable therapy cyclosporine, azathioprine, methylprednisolone; only...
Background. Cardiovascular disease is the most common cause of death among renal transplant recipients (RTRs). Impaired fibrinolytic capacity caused by an increase in plasminogen activator inhibitor type 1 (PAI-1) levels involved onset atherosclerosis and thrombotic complications. Long-term steroid treatment may induce arterial hypertension metabolic prothrombotic changes (including up-regulation PAI-1 synthesis), which cardiovascular risk. We evaluated plasma behavior two groups RTRs...
Abstract Immunosuppresive treatment and secondary hyperparathyroidism (SHPT) are considered among the most important pathogenetic factors for postrenal transplant bone disease. The aim of this study was to investigate relationships vitamin D receptor (VDR) gene polymorphism, parathyroid hormone (PTH) levels, density in renal recipients. We enrolled 69 patients (47 men 22 women; mean age, 47 ± 11 years) who had undergone kidney transplantation 51 5 months before. All underwent an evaluation...
Post-transplant hypertension is a common occurrence during treatment with calcineurin inhibitors (CNIs) in kidney transplant population. The pathogenesis of vasoconstriction induced by CNIs involves vascular tone alterations and sodium transport regulation. Among the factors involved key role played activation intrarenal renin-angiotensin system enhanced release Angiotensin II (Ang II) increase oxidative stress. A pathway between stress may be identified involvement RhoA/Rho kinase pathway,...