A5101747014- Gestational Diabetes Research and Management
- Diabetes Management and Research
- Diabetes Management and Education
- Bariatric Surgery and Outcomes
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Cellular transport and secretion
- Pancreatic function and diabetes
- Cellular Mechanics and Interactions
- Diabetes Treatment and Management
- Vitamin D Research Studies
- COVID-19 Impact on Reproduction
- Health, Medicine and Society
- Hormonal and reproductive studies
- Cardiovascular Function and Risk Factors
- Thyroid Cancer Diagnosis and Treatment
- Genetics, Aging, and Longevity in Model Organisms
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Obesity and Health Practices
- Maternal Mental Health During Pregnancy and Postpartum
- Sexual function and dysfunction studies
- Organizational Leadership and Management Strategies
- Health, psychology, and well-being
- Chronic Disease Management Strategies
Sapienza University of Rome
2014-2024
Center for Outcomes Research and Clinical Epidemiology
2021
Azienda Ospedaliera Sant'Andrea
2020
IFOM
2009-2017
SARS-Cov2 infection has recently spread to Italy with important consequences on pregnancy management, mother and child health mother-child contact. Breastfeeding improves the of reduces risk neonatal other pathogens that are likely cause serious illness. To date no evidence confirmed COVID-19 vertical transmission from infected pregnant their fetus. However it is well known an can transmit virus through respiratory droplets during breastfeeding or intimate Thus, mothers suspected should...
The TOCA family of F-BAR–containing proteins bind to and remodel lipid bilayers via their conserved F-BAR domains, regulate actin dynamics N-Wasp binding SH3 domains. Thus, these are predicted play a pivotal role in coordinating membrane traffic with during cell migration tissue morphogenesis. By combining genetic analysis Caenorhabditis elegans cellular biochemical experiments mammalian cells, we showed that: i) loss CeTOCA reduced the efficiency Clathrin-mediated endocytosis (CME) oocytes....
Abstract Background This study aims to evaluate : 1) the prevalence of Female Sexual Dysfunction (FSD) in women affected by type 1 Diabetes Mellitus (DM) and control group; 2) correlation between duration DM, HbA1C levels sexual life quality; 3) relationship different methods insulin administration 4) FSD diabetes complications. Methods We selected 33 with DM 39 healthy as controls. Each participant underwent a detailed medical history physical examination completed 6-item Function Index...
Son of Sevenless 1 (SOS1) is a dual guanine nucleotide exchange factor (GEF) that activates the small GTPases RAC and RAS. Although molecular mechanisms RAS GEF catalysis have been unveiled, how SOS1 acquires activity what physio-pathological relevance this much less understood. Here we show tyrosine phosphorylated on Y1196 by ABL. Phosphorylation controls inter-molecular interaction, required to promote nucleotides in vitro for platelet-derived growth (PDGF) activation RAC- RAC-dependent...
To assess the proportion of women with gestational diabetes (GDM) by performing postpartum Oral Glucose Tolerance Test (OGTT) and to identify GDM phenotypes at high-risk dysglycemia (PPD).Observational, retrospective, multicenter study involving consecutive women. Recursive partitioning (RECPAM) analysis was used distinct homogeneous subgroups different PPD risk.From a sample 2,736 women, OGTT performed in 941 (34.4%) whom 217 (23.0%) developed PPD. Insulin-treated having family history...
To assess the GDM recurrence rate in a cohort of pregnant women with prior GDM, to compare two consecutive pregnancies complicated by nonrecurrent and recurrent stratify latter early late GDM.Retrospective study including 113 an index pregnancy (G1), at least postindex (G2) normal glucose tolerance between. The was assessed, maternal neonatal outcomes pancreatic beta cell function were compared those (G1 vs. G2). Women GDM.The 83.2% minimum prevalence 43,4%. pregravid BMI increased between...
Abstract Aim Recently, the relationship between diabetes and mental health has been widely studied. With advent of continuous glucose monitoring (CGM), some researchers have interested in exploring association glucose-related metrics psychological aspects. These studies primarily relied on self-report questionnaires which present limitations. Therefore, multicenter study aims at testing potential associations CGM affective processes derived from narratives about using a sensor. Methods An...
Obesity is a growing emergency in type 1 diabetes (T1D). Sex differences obesity prevalence and its clinical consequences adult T1D subjects have been poorly investigated. The aim of this study was to investigate the severe obesity, correlates, potential sex large cohort participating AMD (Associazione Medici Diabetologi) Annals Initiative Italy.The [body mass index(BMI) ≥30 kg/m2] (BMI ≥ 35 kg/m2) according age, as well obesity-associated variables, long-term complications, pharmacological...
Background & Aims: Breastfeeding improves glucose tolerance in the early postpartum period of women with prior gestational diabetes GDM, but it is unclear whether future risk metabolic alterations, like type 2 diabetes, reduced. The aim this study was to investigate effect lactation, three years after pregnancy, on and lipid metabolism diabetes. Materials Methods: A population (Carpenter Coustan Criteria) evaluated comparison results for "lactating" [BF] versus "nonlactating women" [non BF]....
Aim The primary aim of this study was to assess insulin requirements and carbohydrate ratio (CHO/IR) in normal weight, overweight, obese pregnant women with type 1 diabetes across early, middle, late pregnancy. Methods In multicenter, retrospective, observational we evaluated 86 101 Caucasian under pump treatment. were trained calculate CHO/IR daily by dividing CHO grams every single meal units injected. Since the purpose identify able reach glycemic target, only selected obtained when...
Introduction: The prevalence among pregnant women with diabetes of monogenic due to glucochinase deficit (GCK-MODY) varies from 0 80% in different studies, based on the chosen selection criteria for genetic test. New pregnancy-specific Screening Criteria (NSC), validated an anglo-celtic cohort, have been proposed and include pre-pregnancy BMI 99 mg/dl. Our aim was estimate GCK-MODY evaluate diagnostic performance NSC our population pregnancy. Patients methods: we retrospectively selected...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Background Current guidelines for nonalcoholic fatty liver disease (NAFLD) recommend high volumes and/or intensities of physical activity (PA), the achievement which generally requires participation in supervised exercise training programs that however are difficult to implement routine clinical practice. Conversely, counselling interventions may be more suitable, but result only modest increases moderate-to-vigorous-intensity PA (MVPA). This study assessed whether a counseling intervention...
To explore the subjective experience of physicians working in diabetic settings about their care relationships order to find some unique clues contributing physician professional health and capacity manage patients' adherence.An interview-based exploratory study has been carried out involving 18 (77.8% female) with at least 3 years clinical practice diabetes care. In-depth interviews emotional patients were conducted audio recorded. Interviews transcripts analyzed through a computer-based...
Gestational diabetes mellitus (GDM) is a risk factor for GDM in next pregnancies.The aims of this observational study are to measure recurrence rate post index pregnancy women with prior and compare maternal neonatal outcomes pancreatic beta cells function two consecutive pregnancies. Methods: Longitudinal 68 (G1), followed by (G2) normal glucose tolerance in-between [G1 vs. G2: age 32,1±4,6 35,5±4,7 years, BMI 24,5 (19,2-42,7) 24,7 (17,5-42,2) kg/m2, ns]. diagnosis according IADPSG...
Purpose: Poor medication adherence in persons with diabetes is a well documented issue, overall leading to worse glycemic control and quality of life. Previous studies have shown that the patient-provider relationship crucial factor for patient management self-care. Most research has focused on perspective, poor attention providers’ relational skills handle interpersonal difficulties concerning care challenges. The purpose present study was explore subjective perspective about so detect some...
Background and Aim: There is no consensus on glycemic targets for the management of GDM. Since women with GDM managed current show still worse pregnancy outcomes than without it, we aim to identify which levels are associated normal particular reference Large Gestational Age (LGA) rate. Methods: This an observational study, involving (IADPSG criteria) from 2016 2019. Glycemic values <90 mg/dl at fasting <130 mg /dl 1h after a meal were "in target." Blood Glucose (BG) clinical...
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