A5089794566- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Pancreatic and Hepatic Oncology Research
- Diabetes Treatment and Management
- Gestational Diabetes Research and Management
- Neuroendocrine Tumor Research Advances
- COVID-19 Clinical Research Studies
- Metabolism, Diabetes, and Cancer
- Bariatric Surgery and Outcomes
- Pregnancy and preeclampsia studies
- Pancreatitis Pathology and Treatment
- Chronic Kidney Disease and Diabetes
- Renal Transplantation Outcomes and Treatments
- Diabetes Management and Education
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Dialysis and Renal Disease Management
- Diet and metabolism studies
- Long-Term Effects of COVID-19
- Immune Cell Function and Interaction
- Genetic Associations and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Function and Risk Factors
- Organ Transplantation Techniques and Outcomes
Vita-Salute San Raffaele University
2014-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2014-2024
Azienda Unità Sanitaria Locale Della Romagna
2024
IRCCS Ospedale San Raffaele
2003-2023
San Raffaele University of Rome
2009-2021
Weatherford College
2021
Associazione Medici Diabetologi
2021
Italian Society of Periodontology and Implantology
2019-2020
Diabetes Foundation
2013
OBJECTIVE Autoimmune diseases, including type 1 diabetes, are thought to have a Th17-cell bias and/or T-regulatory cell (Treg) defect. Understanding whether this is hallmark of patients with diabetes crucial question that still unsolved, largely due the difficulties accessing tissues targeted by disease. RESEARCH DESIGN AND METHODS We phenotypically and functionally characterized Th17 cells Tregs residing in pancreatic-draining lymph nodes (PLNs) 19 63 nondiabetic donors those circulating...
Human type 1 diabetes (T1D) is an autoimmune disease associated with major histocompatibility complex polymorphisms, β-cell autoantibodies, and autoreactive T cells. However, there increasing evidence that innate cells may also play critical roles in T1D. We aimed to monitor peripheral immune early stages of T1D (i.e., healthy autoantibody-positive subjects) more advanced phases the at onset years after diagnosis). found a mild but significant reproducible neutropenia both precedes...
purpose. Diabetic retinopathy (DR) and diabetic nephropathy (DN) are serious microvascular complications of diabetes mellitus. Correlations between severity DR DN computed heritability estimates for were determined in a large, multiethnic sample families. The hypothesis was that (1) the correlates with presence individuals mellitus, (2) is under significant familial influence members multiplex methods. Family Investigation Nephropathy Diabetes (FIND) designed to evaluate genetic basis...
Abstract Purpose: We aimed to assess the safety and efficacy of metformin for treating patients with metastatic pancreatic cancer identify endocrine metabolic phenotypic features or tumor molecular markers associated sensitivity antineoplastic action. Experimental Design: designed an open-label, randomized, phase II trial adding a standard systemic therapy cisplatin, epirubicin, capecitabine, gemcitabine (PEXG) in cancer. Patients ages 18 years older were randomly assigned (1:1) receive PEXG...
The Family Investigation of Nephropathy and Diabetes (FIND) was initiated to map genes underlying susceptibility diabetic nephropathy. A total 11 centers participated under a single collection protocol recruit large numbers sibling pairs concordant discordant for We report the findings from first-phase genetic analyses in 1,227 participants 378 pedigrees European-American, African-American, Mexican-American, American Indian descent recruited eight centers. Model-free linkage analyses, using...
Long-term clinical outcome of islet transplantation is hampered by the rejection and recurrence autoimmunity. Accurate monitoring may allow for early detection treatment these potentially compromising immune events. Islet transplant was analyzed in 59 consecutive pancreatic recipients whom baseline de novo posttransplant autoantibodies (GAD antibody, insulinoma-associated protein 2 antigen, zinc transporter type 8 antigen) donor-specific alloantibodies (DSA) were quantified. Thirty-nine...
The aim of the study was to characterise humoral response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with diabetes. Demonstrating ability mount an appropriate antibody presence hyperglycaemia is relevant for comprehension mechanisms related observed worse clinical outcome disease 2019 (COVID-19) pneumonia diabetes and development any future vaccination campaign prevent SARS-CoV-2 infection. Using a highly specific sensitive measurement antibodies by...
We aimed to evaluate the added value of intensive self-monitoring blood glucose (SMBG), structured in timing and frequency, noninsulin-treated patients with type 2 diabetes.The 12-month, randomized, clinical trial enrolled 1,024 diabetes (median baseline HbA1c, 7.3% [IQR, 6.9-7.8%]) at 39 clinics Italy. After standardized education, 501 were randomized monitoring (ISM) 4-point glycemic profiles (fasting, preprandial, 2-h postprandial, postabsorptive measurements) performed 3 days/week; 523...
Aims of this study were 1) to assess sexual function and endocrine profile among fertile type 1 diabetic women during the follicular luteal phases menstrual cycle, 2) compare these results with those obtained healthy who served as control subjects, 3) explore correlations between milieu patients subjects cycle.Fifty diabetes 47 completed a semistructured medical interview filled in self-administered validated instruments evaluate function, depression, distress. Venous blood samples drawn...
OBJECTIVE Few studies have assessed the efficacy of carbohydrate counting in type 1 diabetes, and none validated its patients who are treated with continuous subcutaneous insulin infusion (CSII). The aim our study was to test effect on glycemic control quality life adult diabetes receiving CSII. RESEARCH DESIGN AND METHODS Sixty-one CSII were randomly assigned either learning (intervention) or estimating pre-meal dose usual empirical way (control). At baseline 12 24 weeks, we measured HbA1c,...
The gut environment modulates the pathogenesis of type 1 diabetes (T1D), but how it affects autoimmunity toward pancreatic β-cells, a self-tissue located outside intestine, is still unclear. In small lamina propria dendritic cells (LPDCs) induce peripheral differentiation FoxP3(+) regulatory T (Treg) cells. We tested hypothesis that intestinal milieu impinges on human T1D by affecting Treg cells.We collected duodenal biopsies 10 patients, 16 healthy subjects, and 20 celiac individuals...
The liver is the current site of choice for pancreatic islet transplantation, even though it far from being ideal. We recently have shown in mice that bone marrow (BM) may be a valid alternative to liver, and here we report pilot study test feasibility safety BM as transplantation humans. Four patients who developed diabetes after total pancreatectomy were candidates autologous islet. Because had contraindications intraportal infusion, islets infused BM. In all recipients, engrafted...
Abstract Context Demonstrating the ability to mount a neutralizing antibody response SARS-CoV-2 in presence of diabetes is crucial understand COVID-19 pathogenesis, reinfection potential, and vaccine development. Objective The aim this study was characterize kinetics durability (Nab) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hyperglycemia. Methods Using lentiviral vector–based neutralization assay measure Nabs, we characterized 150 patients randomly selected from...
Diabetic nephropathy, the most common cause of end-stage renal disease, aggregates in families and specific ethnic groups. Deconstructing diabetic nephropathy into intermediate, quantitative phenotypes may increase feasibility detecting susceptibility loci by genetic screens. Glomerular filtration rate (GFR), which characterizes was employed as a trait preliminary whole-genome scan.
The cytological Ki-67 expression measured on samples collected by endoscopic ultrasonography-guided fine needle aspiration cytology (EUS-FNAC) may provide pre-operative indications for pancreatic endocrine tumours (PETs) management. aim of our study was to assess reliability obtained EUS-FNAC in patients with PETs. Eighteen PETs underwent before surgery. FNACs and histological sections. Using a cut-off 2%, percent agreement 89% (k-statistic: 0.78, 95% confidence intervals (95% CI): 0.5,...
To assess metabolic and oncologic outcomes of islet autotransplantation (IAT) in patients undergoing pancreatic surgery for either benign or malignant disease.IAT is performed to improve glycemic control after extended pancreatectomy, almost exclusively with chronic pancreatitis. Limited experience available other indications malignancy.In addition pancreatitis, IAT were grade C fistula (treated completion left as indicated); total pancreatectomy an alternative high-risk anastomosis during...
Islet autotransplantation (IAT) is usually performed in patients undergoing pancreatic surgery for chronic pancreatitis. In the present series, IAT was offered also to both nonmalignant and malignant diseases, having either completion pancreatectomy as treatment severe fistulas (n = 21) or extensive distal neoplasms of neck 19) pancreatoduodenectomy because high risk fistula 32). Fifty-eight 72 who were eligible this broader spectrum indication actually received IAT. There no evidence a...
To assess whether dysglycemia diagnosed during severe acute respiratory syndrome coronavirus 2 pneumonia may become a potential public health problem after resolution of the infection. In an adult cohort with suspected disease 2019 (COVID-19) pneumonia, we integrated glucose data upon hospital admission fasting blood (FBG) in year prior to COVID-19 and postdischarge follow-up.From February 25 May 15, 2020, 660 adults were admitted San Raffaele Hospital (Milan, Italy). Through structured...
To compare pancreaticoduodenectomy (PD) and total pancreatectomy (TP) with islet autotransplantation (IAT) in patients at high risk of postoperative pancreatic fistula (POPF).
The Review of Diabetic Studies,2011,8,1,44-50.DOI:10.1900/RDS.2011.8.44Published:May 2011Type:Review ArticleAuthors:Paola Maffi, Marina Scavini, Carlo Socci, Lorenzo Piemonti, Rossana Caldara, Chiara Gremizzi, Raffaella Melzi, Rita Nano, Elena Orsenigo, Massimo Venturini, Staudacher, Alessandro Del Maschio, and Antonio Secchi Author(s) affiliations:Paola Diabetes Research Institute, San Raffaele Scientific Via Olgettina 60, 20132 Milano, Italy. Abstract:Background: Pancreas islet...
Background: Identifying whether the COVID-19 outbreak differentially affects males and females is an important step to understand direct indirect effects of this health emergency. The aim study was describe effect sex on crude cumulative rate confirmed SARS-COV-2 infections deaths for different age categories in six European countries. Methods: most recent available numbers cases infected individuals deaths, stratified by were retrieved from government sources Italy, Spain, Germany,...